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Article: Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma

TitleDown-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma
Authors
KeywordsCellular retinol binding protein
Prognosis
Issue Date2007
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00432/index.htm
Citation
Journal Of Cancer Research And Clinical Oncology, 2007, v. 133 n. 12, p. 929-936 How to Cite?
AbstractPurpose: Acyclic retinoid (ACR) has been shown to be a promising chemopreventive agent for hepatocellular carcinoma (HCC) after curative resection. The effects of retinoid are mediated by retinol-binding proteins (RBPs) through regulating cell proliferation and differentiation. Patients and methods: This study investigated the clinical significance of RBP5 in HCC. RBP5 mRNA level was examined by real-time quantitative PCR on 52 matched tumor and adjacent non-tumor liver tissues, and on ten normal livers. Expression of RBP5 protein was examined using Western blotting analysis and immunohistochemistry. Results: Down-regulation of RBP5 was found in HCC tissues at both mRNA and protein levels. Decreased RBP5 level was closely related to poor differentiation (P = 0.02) and large tumor size (P = 0.01). Low level of RPB5 was associated with poor overall survival (P = 0.02), and was an independent prognostic factor for HCC. Conclusions: Our study revealed that RBP5 down-regulation in HCC was associated with aggressive tumor features, suggesting an important role of RPB5 in HCC progression. © 2007 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/88803
ISSN
2015 Impact Factor: 3.141
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, JCYen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorPoon, WSen_HK
dc.contributor.authorLee, YTen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T09:48:12Z-
dc.date.available2010-09-06T09:48:12Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Cancer Research And Clinical Oncology, 2007, v. 133 n. 12, p. 929-936en_HK
dc.identifier.issn0171-5216en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88803-
dc.description.abstractPurpose: Acyclic retinoid (ACR) has been shown to be a promising chemopreventive agent for hepatocellular carcinoma (HCC) after curative resection. The effects of retinoid are mediated by retinol-binding proteins (RBPs) through regulating cell proliferation and differentiation. Patients and methods: This study investigated the clinical significance of RBP5 in HCC. RBP5 mRNA level was examined by real-time quantitative PCR on 52 matched tumor and adjacent non-tumor liver tissues, and on ten normal livers. Expression of RBP5 protein was examined using Western blotting analysis and immunohistochemistry. Results: Down-regulation of RBP5 was found in HCC tissues at both mRNA and protein levels. Decreased RBP5 level was closely related to poor differentiation (P = 0.02) and large tumor size (P = 0.01). Low level of RPB5 was associated with poor overall survival (P = 0.02), and was an independent prognostic factor for HCC. Conclusions: Our study revealed that RBP5 down-regulation in HCC was associated with aggressive tumor features, suggesting an important role of RPB5 in HCC progression. © 2007 Springer-Verlag.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00432/index.htmen_HK
dc.relation.ispartofJournal of Cancer Research and Clinical Oncologyen_HK
dc.subjectCellular retinol binding proteinen_HK
dc.subjectPrognosisen_HK
dc.subject.meshCarcinoma, Hepatocellular - genetics - metabolism - mortalityen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshDown-Regulationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLiveren_HK
dc.subject.meshLiver Neoplasms - genetics - metabolism - mortalityen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRetinol-Binding Proteins - metabolismen_HK
dc.subject.meshRetinol-Binding Proteins, Cellular - metabolismen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleDown-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0171-5216&volume=133&issue=12&spage=929&epage=936&date=2007&atitle=Down-regulation+of+retinol+binding+protein+5+is+associated+with+aggressive+tumor+features+in+hepatocellular+carcinomaen_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00432-007-0230-0en_HK
dc.identifier.pmid17497168-
dc.identifier.scopuseid_2-s2.0-35248824027en_HK
dc.identifier.hkuros140967en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-35248824027&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133en_HK
dc.identifier.issue12en_HK
dc.identifier.spage929en_HK
dc.identifier.epage936en_HK
dc.identifier.isiWOS:000250063800003-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridHo, JCY=7402650284en_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridPoon, WS=35082584500en_HK
dc.identifier.scopusauthoridLee, YT=22734702300en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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