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Article: Dopamine receptor D4 (DRD4) gene in Han Chinese children with Attention-Deficit/Hyperactivity Disorder (ADHD): Increased prevalence of the 2-repeat allele

TitleDopamine receptor D4 (DRD4) gene in Han Chinese children with Attention-Deficit/Hyperactivity Disorder (ADHD): Increased prevalence of the 2-repeat allele
Authors
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 133 B n. 1, p. 54-56 How to Cite?
Abstract
There is an increased prevalence of the 7-repeat (7R) allele of the dopamine receptor D4 (DRD4) gene in attention-deficit/hyperactivity disorder (ADHD). However, the population prevalence of the 7R allele varies considerably across ethnicity and is very low in Asians. To test whether this 7R allele/ADHD association still held in a Chinese clinical sample, 32 Han Chinese children with a confirmed ADHD diagnosis and normal IQ who were methylphenidate- responders were genotyped. None of them had a DRD4 7R allele. Instead, we observed a significantly increased prevalence of the 2-repeat (2R) allele in this clinical sample (33%) compared to ethnically-matched controls (20%) (χ2(1d.f.) = 5.90, P = 0.015). This approximately 1.65-fold increase of the 2R allele in our probands is close to the observed increase of the 7R allele in European-ancestry ADHD children. Recent genetic studies have indicated that the 2R allele in Asians is likely derived from the 7R allele. Further, available biochemical data indicate that both the 2R and 7R protein have blunted responses to dopamine compared to the 4R protein. Based on these results, we propose that the observed increased prevalence of the 2R allele in our Han Chinese ADHD probands is still consistent with the TR allele hypothesis of ADHD in European-ancestry children. Recent studies have suggested that any variant from the conserved ancestral 4R allele might potentially alter biochemistry/phenotype. We hypothesize that an increased frequency of any non-4R allele may define the association of the DRD4 gene with ADHD that holds across ethnicity. The present findings, however, obtained with a small ADHD sample size, should be replicated. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/88802
ISSN
2013 Impact Factor: 3.271
ISI Accession Number ID
References

 

Author Affiliations
  1. Hong Kong Hospital Authority
  2. The University of Hong Kong
  3. Vrije Universiteit Amsterdam
  4. UC Irvine
  5. Chinese University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLeung, PWLen_HK
dc.contributor.authorLee, CCen_HK
dc.contributor.authorHung, SFen_HK
dc.contributor.authorHo, TPen_HK
dc.contributor.authorTang, CPen_HK
dc.contributor.authorKwong, SLen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLiehMak, Fen_HK
dc.contributor.authorOosterlaan, Jen_HK
dc.contributor.authorGrady, Den_HK
dc.contributor.authorHarxhi, Aen_HK
dc.contributor.authorDing, YCen_HK
dc.contributor.authorChi, HCen_HK
dc.contributor.authorFlodman, Pen_HK
dc.contributor.authorSchuck, Sen_HK
dc.contributor.authorSpence, MAen_HK
dc.contributor.authorMoyzis, Ren_HK
dc.contributor.authorSwanson, Jen_HK
dc.date.accessioned2010-09-06T09:48:11Z-
dc.date.available2010-09-06T09:48:11Z-
dc.date.issued2005en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 133 B n. 1, p. 54-56en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88802-
dc.description.abstractThere is an increased prevalence of the 7-repeat (7R) allele of the dopamine receptor D4 (DRD4) gene in attention-deficit/hyperactivity disorder (ADHD). However, the population prevalence of the 7R allele varies considerably across ethnicity and is very low in Asians. To test whether this 7R allele/ADHD association still held in a Chinese clinical sample, 32 Han Chinese children with a confirmed ADHD diagnosis and normal IQ who were methylphenidate- responders were genotyped. None of them had a DRD4 7R allele. Instead, we observed a significantly increased prevalence of the 2-repeat (2R) allele in this clinical sample (33%) compared to ethnically-matched controls (20%) (χ2(1d.f.) = 5.90, P = 0.015). This approximately 1.65-fold increase of the 2R allele in our probands is close to the observed increase of the 7R allele in European-ancestry ADHD children. Recent genetic studies have indicated that the 2R allele in Asians is likely derived from the 7R allele. Further, available biochemical data indicate that both the 2R and 7R protein have blunted responses to dopamine compared to the 4R protein. Based on these results, we propose that the observed increased prevalence of the 2R allele in our Han Chinese ADHD probands is still consistent with the TR allele hypothesis of ADHD in European-ancestry children. Recent studies have suggested that any variant from the conserved ancestral 4R allele might potentially alter biochemistry/phenotype. We hypothesize that an increased frequency of any non-4R allele may define the association of the DRD4 gene with ADHD that holds across ethnicity. The present findings, however, obtained with a small ADHD sample size, should be replicated. © 2005 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAllelesen_HK
dc.subject.meshAttention Deficit Disorder with Hyperactivity - geneticsen_HK
dc.subject.meshChilden_HK
dc.subject.meshChinaen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMinisatellite Repeats - geneticsen_HK
dc.subject.meshReceptors, Dopamine D2 - geneticsen_HK
dc.subject.meshReceptors, Dopamine D4en_HK
dc.titleDopamine receptor D4 (DRD4) gene in Han Chinese children with Attention-Deficit/Hyperactivity Disorder (ADHD): Increased prevalence of the 2-repeat alleleen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4841&volume=133B&issue=1&spage=54&epage=56&date=2005&atitle=Dopamine+receptor+D4+(DRD4)+gene+in+Han+Chinese+children+with+attention-deficit/hyperactivity+disorder+(ADHD):+increased+prevalence+of+the+2-repeat+alleleen_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ajmg.b.30129en_HK
dc.identifier.pmid15578612en_HK
dc.identifier.scopuseid_2-s2.0-19944432137en_HK
dc.identifier.hkuros108393en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19944432137&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume133 Ben_HK
dc.identifier.issue1en_HK
dc.identifier.spage54en_HK
dc.identifier.epage56en_HK
dc.identifier.isiWOS:000226619600010-
dc.publisher.placeUnited Statesen_HK

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