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Article: Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis

TitleHemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis
Authors
Issue Date2000
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ni
Citation
Nature Immunology, 2000, v. 1 n. 5, p. 392-397 How to Cite?
AbstractWe report here the molecular cloning of a newly identified preprotachykinin gene, Pptc, which specifies the sequence for a new preprotachykinin protein and bioactive peptide designated hemokinin I (HK-1). PPT-C mRNA was detected primarily in hematopoietic cells in contrast to the previously described Ppta and Pptb genes, which are predominantly expressed in neuronal tissues. HK-1 has several biological activities that are similar to the most studied tachykinin, substance P, such as induction of plasma extravasation and mast cell degranulation. However, HK-1 also has properties that are indicative of a critical role in mouse B cell development. HK-1 stimulated the proliferation of interleukin 7-expanded B cell precursors, whereas substance P had no effect. HK-1, but not substance P, promoted the survival of freshly isolated bone marrow B lineage cells or cultured, lipopolysaccharide-stimulated pre-B cells. N-acetyl-L-trytophan-3,5-bistrifluromethyl benzyl ester, a tachykinin receptor antagonist, increased apoptosis of these cells and in vivo administration of this antagonist led to specific reductions of the B220lowCD43- population (the pre-B cell compartment) in the bone marrow and the IgMhighIgDlow population (the newly generated B cells) in the spleen. Thus, HK-1 may be an autocrine factor that is important for the survival of B cell precursors at a critical phase of development.
Persistent Identifierhttp://hdl.handle.net/10722/88773
ISSN
2015 Impact Factor: 19.381
2015 SCImago Journal Rankings: 13.253
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorFurlonger, Cen_HK
dc.contributor.authorWu, GEen_HK
dc.contributor.authorPaige, CJen_HK
dc.date.accessioned2010-09-06T09:47:47Z-
dc.date.available2010-09-06T09:47:47Z-
dc.date.issued2000en_HK
dc.identifier.citationNature Immunology, 2000, v. 1 n. 5, p. 392-397en_HK
dc.identifier.issn1529-2908en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88773-
dc.description.abstractWe report here the molecular cloning of a newly identified preprotachykinin gene, Pptc, which specifies the sequence for a new preprotachykinin protein and bioactive peptide designated hemokinin I (HK-1). PPT-C mRNA was detected primarily in hematopoietic cells in contrast to the previously described Ppta and Pptb genes, which are predominantly expressed in neuronal tissues. HK-1 has several biological activities that are similar to the most studied tachykinin, substance P, such as induction of plasma extravasation and mast cell degranulation. However, HK-1 also has properties that are indicative of a critical role in mouse B cell development. HK-1 stimulated the proliferation of interleukin 7-expanded B cell precursors, whereas substance P had no effect. HK-1, but not substance P, promoted the survival of freshly isolated bone marrow B lineage cells or cultured, lipopolysaccharide-stimulated pre-B cells. N-acetyl-L-trytophan-3,5-bistrifluromethyl benzyl ester, a tachykinin receptor antagonist, increased apoptosis of these cells and in vivo administration of this antagonist led to specific reductions of the B220lowCD43- population (the pre-B cell compartment) in the bone marrow and the IgMhighIgDlow population (the newly generated B cells) in the spleen. Thus, HK-1 may be an autocrine factor that is important for the survival of B cell precursors at a critical phase of development.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nien_HK
dc.relation.ispartofNature Immunologyen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshB-Lymphocytes - cytology - drug effects - immunologyen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshCell Division - drug effectsen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshCell Survival - drug effectsen_HK
dc.subject.meshCloning, Molecularen_HK
dc.subject.meshDNA Primers - geneticsen_HK
dc.subject.meshDNA, Complementary - geneticsen_HK
dc.subject.meshHematopoiesis - drug effectsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshMice, Inbred DBAen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshProtein Precursors - genetics - immunology - pharmacologyen_HK
dc.subject.meshRNA, Messenger - genetics - metabolismen_HK
dc.subject.meshSequence Homology, Amino Aciden_HK
dc.subject.meshTachykinins - genetics - immunology - pharmacologyen_HK
dc.subject.meshTryptophan - analogs & derivatives - pharmacologyen_HK
dc.titleHemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1529-2908&volume=1&issue=5&spage=392&epage=397&date=2000&atitle=Hemokinin+is+a+hematopoietic-specific+tachykinin+that+regulates+B+lymphopoiesisen_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11062498-
dc.identifier.scopuseid_2-s2.0-0034332431en_HK
dc.identifier.hkuros56451en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034332431&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.identifier.issue5en_HK
dc.identifier.spage392en_HK
dc.identifier.epage397en_HK
dc.identifier.isiWOS:000165076100011-
dc.publisher.placeUnited Statesen_HK

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