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Article: Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis

TitleOverexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis
Authors
Ko, SChu, KMLuk, JMWong, BWYuen, STLeung, SYWong, J
KeywordsGastric adenocarcinoma
LI-cadherin
Lymph node metastasis
Tumor marker
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2004, v. 319 n. 2, p. 562-568 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bbrc.2004.04.197
AbstractGastric cancer remains the second leading cause of cancer deaths worldwide. Patients usually present late with local invasion or metastatic diseases. The present study investigated the expression level of liver-intestine cadherin (LI-cadherin) by RT-PCR and its correlation with clinicopathological data in 71 pairs of tumor and non-cancerous gastric mucosa. Protein expression level of LI-cadherin was determined by Western blotting and immunohistochemistry. The mRNA of LI-cadherin was highly expressed in tumor as compared to non-cancerous mucosa. Lymph node metastasis was significantly associated with the expression of LI-cadherin (p=0.038). On multivariate analysis, T staging and LI-cadherin expression were found to be independent factors associated with lymph node metastasis. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/88761
ISSN
0006-291X
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.770
ISI Accession Number ID
WOS:000222062700037
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorKo, Sen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorWong, BWen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T09:47:37Z-
dc.date.available2010-09-06T09:47:37Z-
dc.date.issued2004en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2004, v. 319 n. 2, p. 562-568en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/88761-
dc.description.abstractGastric cancer remains the second leading cause of cancer deaths worldwide. Patients usually present late with local invasion or metastatic diseases. The present study investigated the expression level of liver-intestine cadherin (LI-cadherin) by RT-PCR and its correlation with clinicopathological data in 71 pairs of tumor and non-cancerous gastric mucosa. Protein expression level of LI-cadherin was determined by Western blotting and immunohistochemistry. The mRNA of LI-cadherin was highly expressed in tumor as compared to non-cancerous mucosa. Lymph node metastasis was significantly associated with the expression of LI-cadherin (p=0.038). On multivariate analysis, T staging and LI-cadherin expression were found to be independent factors associated with lymph node metastasis. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectGastric adenocarcinomaen_HK
dc.subjectLI-cadherinen_HK
dc.subjectLymph node metastasisen_HK
dc.subjectTumor markeren_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCadherinsen_HK
dc.subject.meshCarrier Proteins - genetics - metabolismen_HK
dc.subject.meshDNA Primersen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLymphatic Metastasis - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Transport Proteinsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRNA, Messenger - geneticsen_HK
dc.subject.meshStomach Neoplasms - genetics - pathologyen_HK
dc.titleOverexpression of LI-cadherin in gastric cancer is associated with lymph node metastasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=319&issue=2&spage=562&epage=568 &date=2004&atitle=Overexpression+of+LI-cadherin+in+gastric+cancer+is+associated+with+lymph+node+metastasisen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2004.04.197en_HK
dc.identifier.pmid15178443-
dc.identifier.scopuseid_2-s2.0-2642554613en_HK
dc.identifier.hkuros108175en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2642554613&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume319en_HK
dc.identifier.issue2en_HK
dc.identifier.spage562en_HK
dc.identifier.epage568en_HK
dc.identifier.isiWOS:000222062700037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKo, S=7403326231en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridWong, BW=8602085500en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.issnl0006-291X-

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