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Article: Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma

TitleExpression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma
Authors
KeywordsPilocytic astrocytoma
Vascular endothelial growth factor
Vascular permeability factor
Issue Date1997
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 1997, v. 21 n. 8, p. 941-950 How to Cite?
AbstractVascular endothelial growth factor (VEGF), a potent angiogenic and vascular permeability factor, is important in the angiogenesis of glioblastoma. A major difference between pilocytic astrocytoma, a grade I tumor, and the grade II fibrillary astrocytoma is the vascular proliferation, highly vascularized stroma, and great propensity for cyst formation in the former. In order to explore factors regulating such angiogenesis and cyst formation in pilocytic astrocytoma, we examined expression of VEGF and its receptors (KDR and Flt-1) using in situ hybridization. In all 14 cases a high level of VEGF transcripts could be demonstrated. These were found in specific regions, namely, in the tumor cyst wall, in areas of hyaline cystic degeneration, in stellate reticulated astrocytes around microcysts in the biphasic compact and loose areas, and in tumor cells with degenerative pleomorphic multilobated nuclei. KDR and Flt-1 were expressed in the tumor vasculature, with particularly high levels seen in coiled young proliferating vessels, especially those in the cyst wall. Given the known angiogenic and vascular permeability activities of VEGF, we propose that VEGF plays an important role in molding the characteristic morphologic features of this tumor, namely, the formation of cysts, microcystic pattern, hyaline cystic degeneration, hyaline vessels, and vascular proliferation. Mechanisms that block the VEGF pathway could constitute a potential therapeutic strategy for the treatment of this tumor.
Persistent Identifierhttp://hdl.handle.net/10722/88739
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorChan, ASYen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorCheung, Nen_HK
dc.contributor.authorChung, LPen_HK
dc.date.accessioned2010-09-06T09:47:20Z-
dc.date.available2010-09-06T09:47:20Z-
dc.date.issued1997en_HK
dc.identifier.citationAmerican Journal Of Surgical Pathology, 1997, v. 21 n. 8, p. 941-950en_HK
dc.identifier.issn0147-5185en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88739-
dc.description.abstractVascular endothelial growth factor (VEGF), a potent angiogenic and vascular permeability factor, is important in the angiogenesis of glioblastoma. A major difference between pilocytic astrocytoma, a grade I tumor, and the grade II fibrillary astrocytoma is the vascular proliferation, highly vascularized stroma, and great propensity for cyst formation in the former. In order to explore factors regulating such angiogenesis and cyst formation in pilocytic astrocytoma, we examined expression of VEGF and its receptors (KDR and Flt-1) using in situ hybridization. In all 14 cases a high level of VEGF transcripts could be demonstrated. These were found in specific regions, namely, in the tumor cyst wall, in areas of hyaline cystic degeneration, in stellate reticulated astrocytes around microcysts in the biphasic compact and loose areas, and in tumor cells with degenerative pleomorphic multilobated nuclei. KDR and Flt-1 were expressed in the tumor vasculature, with particularly high levels seen in coiled young proliferating vessels, especially those in the cyst wall. Given the known angiogenic and vascular permeability activities of VEGF, we propose that VEGF plays an important role in molding the characteristic morphologic features of this tumor, namely, the formation of cysts, microcystic pattern, hyaline cystic degeneration, hyaline vessels, and vascular proliferation. Mechanisms that block the VEGF pathway could constitute a potential therapeutic strategy for the treatment of this tumor.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_HK
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_HK
dc.rightsAmerican Journal of Surgical Pathology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectPilocytic astrocytomaen_HK
dc.subjectVascular endothelial growth factoren_HK
dc.subjectVascular permeability factoren_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAstrocytoma - blood supply - geneticsen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshBrain Neoplasms - blood supply - geneticsen_HK
dc.subject.meshCerebellar Neoplasms - blood supply - geneticsen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshEndothelial Growth Factors - genetics - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshLymphokines - genetics - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshNeovascularization, Pathologicen_HK
dc.subject.meshParietal Lobeen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshReceptors, Growth Factor - genetics - physiologyen_HK
dc.subject.meshReceptors, Mitogen - genetics - physiologyen_HK
dc.subject.meshReceptors, Vascular Endothelial Growth Factoren_HK
dc.subject.meshSpinal Cord Neoplasms - blood supply - geneticsen_HK
dc.subject.meshTemporal Lobeen_HK
dc.subject.meshTranscription, Geneticen_HK
dc.subject.meshVascular Endothelial Growth Factor Aen_HK
dc.subject.meshVascular Endothelial Growth Factorsen_HK
dc.titleExpression of vascular endothelial growth factor and its receptors in pilocytic astrocytomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-5185&volume=21&issue=8&spage=941&epage=950&date=1997&atitle=Expression+of+vascular+endothelial+growth+factor+and+its+receptors+in+pilocytic+astrocytomaen_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00000478-199708000-00009en_HK
dc.identifier.pmid9255258-
dc.identifier.scopuseid_2-s2.0-0342460613en_HK
dc.identifier.hkuros31283en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0342460613&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue8en_HK
dc.identifier.spage941en_HK
dc.identifier.epage950en_HK
dc.identifier.isiWOS:A1997XW92400009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridChan, ASY=55246984000en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridCheung, N=36803314200en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK

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