File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas

TitleThe angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas
Authors
KeywordsAngiopoietins
Lung carcinoma
Receptor tyrosine kinase Tie2
Vascular endothelial growth factor
Issue Date2000
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
Citation
Lung Cancer, 2000, v. 29 n. 1, p. 11-22 How to Cite?
AbstractThe successful establishment of angiogenesis depends on a complex process of endothelial proliferation and organization. The angiopoietins (Ang-1 and Ang-2) and Tie2 ligand-receptor system is essential for the regulation of vascular maturation and stability during embryonic development. Together with the vascular endothelial growth factor (VEGF)-mediated pathway, they have been implicated in the control of normal physiological angiogenesis. We investigated their potential role and interaction in the development of lung cancers by comparing the expression pattern and inter-relationship of Ang-1 and 2, Tie2 and VEGF levels in 28 pairs of primary non-small cell lung cancers (NSCLC) and normal lung. Using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in-situ hybridization (ISH), we showed that in NSCLC, there was significantly up-regulated VEGF expression by the tumour cells and an increased intensity of Ang-2 expression in the tumour vessels. The number of Ang-2-expressing vessels also correlated with the grades of tumour cell expression of VEGF. On the other hand, normal lung expressed constitutively high and correlated levels of Ang-1 and Tie2, which were significantly reduced in the carcinomas. The findings suggested a role of the Ang-1/Tie2 pathway in the maintenance of the complex vasculature in normal lung, while collaborative activities between the Ang-2 and VEGF pathways might be important in promoting tumour angiogenesis in NSCLC. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/88713
ISSN
2015 Impact Factor: 3.767
2015 SCImago Journal Rankings: 1.923
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, MPen_HK
dc.contributor.authorChan, SYen_HK
dc.contributor.authorFu, KHen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorCheung, Nen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorChung, LPen_HK
dc.date.accessioned2010-09-06T09:46:59Z-
dc.date.available2010-09-06T09:46:59Z-
dc.date.issued2000en_HK
dc.identifier.citationLung Cancer, 2000, v. 29 n. 1, p. 11-22en_HK
dc.identifier.issn0169-5002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88713-
dc.description.abstractThe successful establishment of angiogenesis depends on a complex process of endothelial proliferation and organization. The angiopoietins (Ang-1 and Ang-2) and Tie2 ligand-receptor system is essential for the regulation of vascular maturation and stability during embryonic development. Together with the vascular endothelial growth factor (VEGF)-mediated pathway, they have been implicated in the control of normal physiological angiogenesis. We investigated their potential role and interaction in the development of lung cancers by comparing the expression pattern and inter-relationship of Ang-1 and 2, Tie2 and VEGF levels in 28 pairs of primary non-small cell lung cancers (NSCLC) and normal lung. Using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in-situ hybridization (ISH), we showed that in NSCLC, there was significantly up-regulated VEGF expression by the tumour cells and an increased intensity of Ang-2 expression in the tumour vessels. The number of Ang-2-expressing vessels also correlated with the grades of tumour cell expression of VEGF. On the other hand, normal lung expressed constitutively high and correlated levels of Ang-1 and Tie2, which were significantly reduced in the carcinomas. The findings suggested a role of the Ang-1/Tie2 pathway in the maintenance of the complex vasculature in normal lung, while collaborative activities between the Ang-2 and VEGF pathways might be important in promoting tumour angiogenesis in NSCLC. Copyright (C) 2000 Elsevier Science Ireland Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcanen_HK
dc.relation.ispartofLung Canceren_HK
dc.rightsLung Cancer. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAngiopoietinsen_HK
dc.subjectLung carcinomaen_HK
dc.subjectReceptor tyrosine kinase Tie2en_HK
dc.subjectVascular endothelial growth factoren_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAngiopoietin-1en_HK
dc.subject.meshAngiopoietin-2en_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - blood supply - metabolismen_HK
dc.subject.meshEndothelial Growth Factors - biosynthesisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshLung Neoplasms - blood supply - metabolismen_HK
dc.subject.meshLymphokines - biosynthesisen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMembrane Glycoproteins - biosynthesisen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeovascularization, Pathologic - metabolismen_HK
dc.subject.meshProtein Biosynthesisen_HK
dc.subject.meshReceptor Protein-Tyrosine Kinases - biosynthesisen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshVascular Endothelial Growth Factor Aen_HK
dc.subject.meshVascular Endothelial Growth Factorsen_HK
dc.titleThe angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0169-5002&volume=29&spage=11&epage=22&date=2000&atitle=The+angiopoietins,+tie2+and+vascular+endothelial+growth+factor+are+differentially+expressed+in+the+transformation+of+normal+lung+to+non-small+cell+lung+carcinomasen_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10880843-
dc.identifier.scopuseid_2-s2.0-0034045741en_HK
dc.identifier.hkuros53454en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034045741&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue1en_HK
dc.identifier.spage11en_HK
dc.identifier.epage22en_HK
dc.identifier.isiWOS:000087951700002-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridChan, SY=7404256096en_HK
dc.identifier.scopusauthoridFu, KH=7202283800en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridCheung, N=36803314200en_HK
dc.identifier.scopusauthoridYuen, ST=8323342200en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats