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Article: Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon

TitleTissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon
Authors
KeywordsAngiogenesis
Carcinoma
Colon
Lung
Vascular endothelial growth factor splice variants
Issue Date1998
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1998, v. 29 n. 9, p. 910-914 How to Cite?
AbstractAngiogenesis, a prerequisite for tumor growth and progression, results from a shift in the equilibrium between angiogenic factors and angiogenic inhibitors. Vascular endothelial growth factor (VEGF) has been identified as one of the most important factors mediating angiogenesis in physiological and pathological conditions. Through alternative splicing, four isoforms of VEGF are formed, consisting of 206, 189, 165, and 121 amino acids, respectively. VEGF206 and VEGF189 differ from VEGF165 and VEGF121 in their bioavailability, with the longer forms being matrix-bound and the shorter forms freely diffusible. To investigate the relative importance of the VEGF isoforms in neoplastic transformation, we studied the pattern of splice variant expression by reverse transcription polymerase chain reaction (RT-PGR) in 18 lung and 11 colonic carcinomas and their corresponding normal tissues, respectively. The findings showed a significant upregulation of VEGF in both carcinomas, with VEGF165 and VEGF121 being the predominant forms; VEGF189 was significantly expressed in normal lung but not colon; and VEGF206 was not detected in any specimen. The findings indicate that during malignant progression, an angiogenic switch favoring the shorter diffusible isoforms is likely to confer on the tumor a growth advantage. From the differential expression of VEGF isoforms in normal lung and colonic tissues, different functional roles of the splice variants is suggested. In particular, VEGF189 may be important for the maintenance of the vascular integrity of the lung.
Persistent Identifierhttp://hdl.handle.net/10722/88689
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorChung, LPen_HK
dc.date.accessioned2010-09-06T09:46:41Z-
dc.date.available2010-09-06T09:46:41Z-
dc.date.issued1998en_HK
dc.identifier.citationHuman Pathology, 1998, v. 29 n. 9, p. 910-914en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88689-
dc.description.abstractAngiogenesis, a prerequisite for tumor growth and progression, results from a shift in the equilibrium between angiogenic factors and angiogenic inhibitors. Vascular endothelial growth factor (VEGF) has been identified as one of the most important factors mediating angiogenesis in physiological and pathological conditions. Through alternative splicing, four isoforms of VEGF are formed, consisting of 206, 189, 165, and 121 amino acids, respectively. VEGF206 and VEGF189 differ from VEGF165 and VEGF121 in their bioavailability, with the longer forms being matrix-bound and the shorter forms freely diffusible. To investigate the relative importance of the VEGF isoforms in neoplastic transformation, we studied the pattern of splice variant expression by reverse transcription polymerase chain reaction (RT-PGR) in 18 lung and 11 colonic carcinomas and their corresponding normal tissues, respectively. The findings showed a significant upregulation of VEGF in both carcinomas, with VEGF165 and VEGF121 being the predominant forms; VEGF189 was significantly expressed in normal lung but not colon; and VEGF206 was not detected in any specimen. The findings indicate that during malignant progression, an angiogenic switch favoring the shorter diffusible isoforms is likely to confer on the tumor a growth advantage. From the differential expression of VEGF isoforms in normal lung and colonic tissues, different functional roles of the splice variants is suggested. In particular, VEGF189 may be important for the maintenance of the vascular integrity of the lung.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectAngiogenesisen_HK
dc.subjectCarcinomaen_HK
dc.subjectColonen_HK
dc.subjectLungen_HK
dc.subjectVascular endothelial growth factor splice variantsen_HK
dc.subject.meshAdenocarcinoma - metabolismen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - metabolismen_HK
dc.subject.meshCell Transformation, Neoplastic - metabolismen_HK
dc.subject.meshColonic Neoplasms - metabolismen_HK
dc.subject.meshEndothelial Growth Factors - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLung Neoplasms - metabolismen_HK
dc.subject.meshLymphokines - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshRNA - analysisen_HK
dc.subject.meshTissue Distributionen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.subject.meshVascular Endothelial Growth Factor Aen_HK
dc.subject.meshVascular Endothelial Growth Factorsen_HK
dc.titleTissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colonen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=29&issue=9&spage=910&epage=914&date=1998&atitle=Tissue-specific+expression+pattern+of+vascular+endothelial+growth+factor+isoforms+in+the+malignant+transformation+of+lung+and+colonen_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0046-8177(98)90195-2en_HK
dc.identifier.pmid9744306-
dc.identifier.scopuseid_2-s2.0-0031668734en_HK
dc.identifier.hkuros63370en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031668734&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue9en_HK
dc.identifier.spage910en_HK
dc.identifier.epage914en_HK
dc.identifier.isiWOS:000075880700005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, N=36803314200en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK

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