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Article: Hypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells

TitleHypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells
Authors
KeywordsCell migration
Dendritic cell
Hypoxia
Matrix metalloproteinase
Issue Date2005
PublisherNature Publishing Group.
Citation
Immunology And Cell Biology, 2005, v. 83 n. 6, p. 668-673 How to Cite?
AbstractHypoxia, a prominent characteristic of inflammatory tissue lesions and solid tumour microenvironments, is a crucial stimulus capable of modulating the expression of specific genes involved in leucocyte recruitment. Although studies have shown that hypoxia can affect leucocyte migration by influencing the expression of migration-related genes, such as matrix metalloproteinases (MMP) and their endogenous tissue inhibitors of matrix metalloproteinases (TIMP), it remains unclear whether hypoxia can affect the migration of dendritic cells (DC). In this study, we showed that human monocyte-derived DC under hypoxic conditions in a transwell system have significantly reduced migratory capacity compared to normoxic controls. A moderate phenotypic change of hypoxic DC was observed. In hypoxic DC, we detected a twofold increase in TIMP-1 transcript levels, and downregulated expression of MMP-9 and membrane type 1-MMP genes by threefold and 17-fold, respectively. Our results suggest that hypoxia may inhibit DC migratory activity by regulating the balance between MMP and TIMP gene expression. © 2005 Australasian Society for Immunology Inc.
Persistent Identifierhttp://hdl.handle.net/10722/88667
ISSN
2015 Impact Factor: 4.473
2015 SCImago Journal Rankings: 2.542
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQu, Xen_HK
dc.contributor.authorYang, MXen_HK
dc.contributor.authorKong, BHen_HK
dc.contributor.authorQi, Len_HK
dc.contributor.authorLam, QLKen_HK
dc.contributor.authorYan, Sen_HK
dc.contributor.authorLi, Pen_HK
dc.contributor.authorZhang, Men_HK
dc.contributor.authorLu, Len_HK
dc.date.accessioned2010-09-06T09:46:22Z-
dc.date.available2010-09-06T09:46:22Z-
dc.date.issued2005en_HK
dc.identifier.citationImmunology And Cell Biology, 2005, v. 83 n. 6, p. 668-673en_HK
dc.identifier.issn0818-9641en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88667-
dc.description.abstractHypoxia, a prominent characteristic of inflammatory tissue lesions and solid tumour microenvironments, is a crucial stimulus capable of modulating the expression of specific genes involved in leucocyte recruitment. Although studies have shown that hypoxia can affect leucocyte migration by influencing the expression of migration-related genes, such as matrix metalloproteinases (MMP) and their endogenous tissue inhibitors of matrix metalloproteinases (TIMP), it remains unclear whether hypoxia can affect the migration of dendritic cells (DC). In this study, we showed that human monocyte-derived DC under hypoxic conditions in a transwell system have significantly reduced migratory capacity compared to normoxic controls. A moderate phenotypic change of hypoxic DC was observed. In hypoxic DC, we detected a twofold increase in TIMP-1 transcript levels, and downregulated expression of MMP-9 and membrane type 1-MMP genes by threefold and 17-fold, respectively. Our results suggest that hypoxia may inhibit DC migratory activity by regulating the balance between MMP and TIMP gene expression. © 2005 Australasian Society for Immunology Inc.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group.en_HK
dc.relation.ispartofImmunology and Cell Biologyen_HK
dc.subjectCell migrationen_HK
dc.subjectDendritic cellen_HK
dc.subjectHypoxiaen_HK
dc.subjectMatrix metalloproteinaseen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Hypoxia - physiologyen_HK
dc.subject.meshCell Movementen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshDendritic Cells - cytology - metabolismen_HK
dc.subject.meshGene Expression Regulationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMonocytes - cytologyen_HK
dc.subject.meshPhenotypeen_HK
dc.titleHypoxia inhibits the migratory capacity of human monocyte-derived dendritic cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0818-9641&volume=83&issue=6&spage=668&epage=73&date=2005&atitle=Hypoxia+inhibits+the+migratory+capacity+of+human+monocyte-derived+dendritic+cellsen_HK
dc.identifier.emailLam, QLK: qlam@pathology.hku.hken_HK
dc.identifier.emailLu, L: liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLam, QLK=rp00312en_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1711.2005.01383.xen_HK
dc.identifier.pmid16266319-
dc.identifier.scopuseid_2-s2.0-30544442386en_HK
dc.identifier.hkuros114089en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-30544442386&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue6en_HK
dc.identifier.spage668en_HK
dc.identifier.epage673en_HK
dc.identifier.isiWOS:000232772900010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridQu, X=8924791300en_HK
dc.identifier.scopusauthoridYang, MX=13309541800en_HK
dc.identifier.scopusauthoridKong, BH=7005061628en_HK
dc.identifier.scopusauthoridQi, L=8979493100en_HK
dc.identifier.scopusauthoridLam, QLK=8722491000en_HK
dc.identifier.scopusauthoridYan, S=36601650300en_HK
dc.identifier.scopusauthoridLi, P=26643192100en_HK
dc.identifier.scopusauthoridZhang, M=8416776200en_HK
dc.identifier.scopusauthoridLu, L=7403963552en_HK
dc.identifier.citeulike362204-

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