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Article: Nitric oxide and iron metabolism in exercised rat with L-arginine supplementation

TitleNitric oxide and iron metabolism in exercised rat with L-arginine supplementation
Authors
Issue Date2003
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2003, v. 252 n. 1-2, p. 65-72 How to Cite?
AbstractThe present study was designed to investigate whether L-arginine (Arg) supplementation in exercise affects nitric oxide (NO) synthesis in tissues and thus iron metabolism. Rats were assigned to one of four groups: EG (Exercise), SG (Sedentary), EAG (Exercise + Arg), and SAG (Sedentary + Arg). Both EG and EAG swam 2 h/day for 3 months. Both SAG and EAG received 3% Arg supplementation in their drinking water. The results showed that Arg supplementation in exercise (EAG) significantly increased nitrite and nitrate (NOx) concentration in the kidney and BMC, rather than in the liver, spleen and heart. Arg supplementation significantly increased both nonheme iron (NHI) and catalytic iron (CI) content in the kidney, to the extent that the ratio of CI/NHI or storage iron (SI)/NHI was not significantly affected, and significantly decreased NHI content and increased CI content in BMC, to the extent that SI content or SI/NHI was significantly decreased. These findings suggest that Arg supplementation in exercise, possibly through increasing NO synthesis, may change CI formation in the kidney and BMC, and affect iron storage in BMC rather than in the kidney.
Persistent Identifierhttp://hdl.handle.net/10722/88665
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXiao, DSen_HK
dc.contributor.authorJiang, Len_HK
dc.contributor.authorChe, LLen_HK
dc.contributor.authorLu, Len_HK
dc.date.accessioned2010-09-06T09:46:21Z-
dc.date.available2010-09-06T09:46:21Z-
dc.date.issued2003en_HK
dc.identifier.citationMolecular And Cellular Biochemistry, 2003, v. 252 n. 1-2, p. 65-72en_HK
dc.identifier.issn0300-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88665-
dc.description.abstractThe present study was designed to investigate whether L-arginine (Arg) supplementation in exercise affects nitric oxide (NO) synthesis in tissues and thus iron metabolism. Rats were assigned to one of four groups: EG (Exercise), SG (Sedentary), EAG (Exercise + Arg), and SAG (Sedentary + Arg). Both EG and EAG swam 2 h/day for 3 months. Both SAG and EAG received 3% Arg supplementation in their drinking water. The results showed that Arg supplementation in exercise (EAG) significantly increased nitrite and nitrate (NOx) concentration in the kidney and BMC, rather than in the liver, spleen and heart. Arg supplementation significantly increased both nonheme iron (NHI) and catalytic iron (CI) content in the kidney, to the extent that the ratio of CI/NHI or storage iron (SI)/NHI was not significantly affected, and significantly decreased NHI content and increased CI content in BMC, to the extent that SI content or SI/NHI was significantly decreased. These findings suggest that Arg supplementation in exercise, possibly through increasing NO synthesis, may change CI formation in the kidney and BMC, and affect iron storage in BMC rather than in the kidney.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_HK
dc.relation.ispartofMolecular and Cellular Biochemistryen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshArginine - administration & dosageen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshIron - blood - metabolismen_HK
dc.subject.meshNitric Oxide - blood - metabolismen_HK
dc.subject.meshPhysical Conditioning, Animalen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleNitric oxide and iron metabolism in exercised rat with L-arginine supplementationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-8177&volume=252&issue=1-2&spage=65&epage=72&date=2003&atitle=Nitric+oxide+and+iron+metabolism+in+exercised+rat+with+L-arginine+supplementationen_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1025517216681en_HK
dc.identifier.pmid14577577-
dc.identifier.scopuseid_2-s2.0-0141839822en_HK
dc.identifier.hkuros86119en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141839822&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume252en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage65en_HK
dc.identifier.epage72en_HK
dc.identifier.isiWOS:000185125600008-
dc.publisher.placeUnited Statesen_HK

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