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Article: Expression of p27KIP1 and p21WAF1/CIP1 in primary hepatocellular carcinoma: Clinicopathologic correlation and survival analysis

TitleExpression of p27KIP1 and p21WAF1/CIP1 in primary hepatocellular carcinoma: Clinicopathologic correlation and survival analysis
Authors
Issue Date2001
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2001, v. 32 n. 8, p. 778-784 How to Cite?
AbstractTo investigate the possible roles of p27KIP1 and p21WAF1/CIP1, inhibitors of cyclin-dependent kinases, in hepatocellular carcinoma (HCC), we examined p27KIP1 and p21WAF1/CIP1 expression in primary HCC with immunohistochemistry and Northern blot hybridization and correlated the results with clinicopathologic features and survival. With immunohistochemistry, positive staining for p27KIP1 and p21WAF1/CIP1 protein was found in 54.3% and 63.8% of HCCs, respectively. Both p27KIP1 and p21WAF1/CIP1 scores of the tumors were significantly higher than those of the corresponding nontumorous livers (P < .0001 and .009, respectively). Higher leveis of p27KIP1 were associated with a lower incidence of direct liver invasion (P = .021) and, less significantly, with a low incidence of multiple tumor nodules (P = .056). Patients whose tumors had higher p27KIP1 protein scores had longer disease-free survival (P = .011). For p21WAF1/CIP1 in contrast to the overexpression of the p21WAF1/CIP1 protein in HCC, the relative amounts of p21WAF1/CIP1 messenger RNA (mRNA) in the tumors were found to be reduced compared with those of the nontumorous livers (P = .039). In conclusion, p27KIP1 and p21WAF1/CIP1 proteins were frequently overexpressed in HCC. Longer disease-free survival rates were seen in patients whose tumors had higher p27KIP1 expression. The accumulation of p21WAF1/CIP protein in the presence of a reduced mRNA level suggests probable posttranslational protein stabilization, and the reduced transcription of p21WAF1/CIP may represent a form of dysfunction of cyclin-dependent kinase inhibitor involved in hepatocarcinogenesis. Copyright © 2001 by W.B. Saunders Company.
Persistent Identifierhttp://hdl.handle.net/10722/88651
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQin, LFen_HK
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-09-06T09:46:10Z-
dc.date.available2010-09-06T09:46:10Z-
dc.date.issued2001en_HK
dc.identifier.citationHuman Pathology, 2001, v. 32 n. 8, p. 778-784en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88651-
dc.description.abstractTo investigate the possible roles of p27KIP1 and p21WAF1/CIP1, inhibitors of cyclin-dependent kinases, in hepatocellular carcinoma (HCC), we examined p27KIP1 and p21WAF1/CIP1 expression in primary HCC with immunohistochemistry and Northern blot hybridization and correlated the results with clinicopathologic features and survival. With immunohistochemistry, positive staining for p27KIP1 and p21WAF1/CIP1 protein was found in 54.3% and 63.8% of HCCs, respectively. Both p27KIP1 and p21WAF1/CIP1 scores of the tumors were significantly higher than those of the corresponding nontumorous livers (P < .0001 and .009, respectively). Higher leveis of p27KIP1 were associated with a lower incidence of direct liver invasion (P = .021) and, less significantly, with a low incidence of multiple tumor nodules (P = .056). Patients whose tumors had higher p27KIP1 protein scores had longer disease-free survival (P = .011). For p21WAF1/CIP1 in contrast to the overexpression of the p21WAF1/CIP1 protein in HCC, the relative amounts of p21WAF1/CIP1 messenger RNA (mRNA) in the tumors were found to be reduced compared with those of the nontumorous livers (P = .039). In conclusion, p27KIP1 and p21WAF1/CIP1 proteins were frequently overexpressed in HCC. Longer disease-free survival rates were seen in patients whose tumors had higher p27KIP1 expression. The accumulation of p21WAF1/CIP protein in the presence of a reduced mRNA level suggests probable posttranslational protein stabilization, and the reduced transcription of p21WAF1/CIP may represent a form of dysfunction of cyclin-dependent kinase inhibitor involved in hepatocarcinogenesis. Copyright © 2001 by W.B. Saunders Company.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlotting, Northernen_HK
dc.subject.meshCarcinoma, Hepatocellular - metabolism - mortality - pathology - surgeryen_HK
dc.subject.meshCell Cycle Proteins - metabolismen_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p21en_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p27en_HK
dc.subject.meshCyclin-Dependent Kinases - antagonists & inhibitorsen_HK
dc.subject.meshCyclins - genetics - metabolismen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshLiver Neoplasms - metabolism - mortality - pathology - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Invasiveness - pathologyen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRNA, Neoplasm - analysisen_HK
dc.subject.meshSurvival Rateen_HK
dc.subject.meshTumor Suppressor Proteinsen_HK
dc.titleExpression of p27KIP1 and p21WAF1/CIP1 in primary hepatocellular carcinoma: Clinicopathologic correlation and survival analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=32&issue=8&spage=778&epage=784&date=2001&atitle=Expression+of+p27KIP1+and+p21WAF1/CIP1+in+primary+hepatocellular+carcinoma:+clinicopathologic+correlation+and+survival+analysisen_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/hupa.2001.27105en_HK
dc.identifier.pmid11521219-
dc.identifier.scopuseid_2-s2.0-0034869599en_HK
dc.identifier.hkuros66019en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034869599&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue8en_HK
dc.identifier.spage778en_HK
dc.identifier.epage784en_HK
dc.identifier.isiWOS:000170750900003-
dc.publisher.placeUnited Statesen_HK

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