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Article: Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: Results of a multicenter study

TitleHepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: Results of a multicenter study
Authors
Issue Date2005
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/surg
Citation
Surgery, 2005, v. 137 n. 4, p. 403-410 How to Cite?
AbstractBackground. The role of hepatic resection in patients with hepatocellular carcinoma (HCC) and invasion of a main portal or hepatic vein branch is controversial. We evaluated the efficacy of hepatic resection and the factors affecting survival after resection in such patients. Methods. The records of 102 patients who underwent resection for HCC with major vascular invasion between 1984 and 1999 were reviewed. Prognostic factors were evaluated by univariate and multivariate analysis. Results. The study included 87 men and 15 women. The median age was 59 years. The perioperative mortality rate was 5.9%. Median survival was 11 months (median follow-up, 93 months). The 1-, 3-, and 5-year survival rates were 45%, 17%, and 10%; the longest-living survivor was still alive at 14.8 years. Absence of moderate to severe fibrosis and absence of high nuclear grade were associated with a better 5-year survival rate (23% vs 5%; P =. 001 and 21% vs 9%; P =. 04, respectively). On multivariate analysis, moderate to severe fibrosis remained a significant predictor of both short-term (≤ 6 months) and long-term (>6 months) survival (P <. 03 and P <. 01, respectively). Conclusions. Hepatic resection for HCC with major vascular invasion is associated with median survival exceeding historical survival in patients not treated surgically. Patients with HCC and major vascular invasion who derive long-term benefit from resection have no or minimal underlying fibrosis. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/88648
ISSN
2015 Impact Factor: 3.309
2015 SCImago Journal Rankings: 1.620
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPawlik, TMen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorAbdalla, EKen_HK
dc.contributor.authorIkai, Ien_HK
dc.contributor.authorNagorney, DMen_HK
dc.contributor.authorBelghiti, Jen_HK
dc.contributor.authorKianmanesh, Ren_HK
dc.contributor.authorOiLin Ng, Ien_HK
dc.contributor.authorCurley, SAen_HK
dc.contributor.authorYamaoka, Yen_HK
dc.contributor.authorLauwers, GYen_HK
dc.contributor.authorVauthey, JNen_HK
dc.date.accessioned2010-09-06T09:46:08Z-
dc.date.available2010-09-06T09:46:08Z-
dc.date.issued2005en_HK
dc.identifier.citationSurgery, 2005, v. 137 n. 4, p. 403-410en_HK
dc.identifier.issn0039-6060en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88648-
dc.description.abstractBackground. The role of hepatic resection in patients with hepatocellular carcinoma (HCC) and invasion of a main portal or hepatic vein branch is controversial. We evaluated the efficacy of hepatic resection and the factors affecting survival after resection in such patients. Methods. The records of 102 patients who underwent resection for HCC with major vascular invasion between 1984 and 1999 were reviewed. Prognostic factors were evaluated by univariate and multivariate analysis. Results. The study included 87 men and 15 women. The median age was 59 years. The perioperative mortality rate was 5.9%. Median survival was 11 months (median follow-up, 93 months). The 1-, 3-, and 5-year survival rates were 45%, 17%, and 10%; the longest-living survivor was still alive at 14.8 years. Absence of moderate to severe fibrosis and absence of high nuclear grade were associated with a better 5-year survival rate (23% vs 5%; P =. 001 and 21% vs 9%; P =. 04, respectively). On multivariate analysis, moderate to severe fibrosis remained a significant predictor of both short-term (≤ 6 months) and long-term (>6 months) survival (P <. 03 and P <. 01, respectively). Conclusions. Hepatic resection for HCC with major vascular invasion is associated with median survival exceeding historical survival in patients not treated surgically. Patients with HCC and major vascular invasion who derive long-term benefit from resection have no or minimal underlying fibrosis. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/surgen_HK
dc.relation.ispartofSurgeryen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCarcinoma, Hepatocellular - mortality - pathology - surgeryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHepatectomy - mortalityen_HK
dc.subject.meshHepatic Veins - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - mortality - pathology - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Invasivenessen_HK
dc.subject.meshPortal Vein - pathologyen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTime Factorsen_HK
dc.titleHepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: Results of a multicenter studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0263-9319&volume=137&issue=4&spage=403&epage=410&date=2005&atitle=Hepatectomy+for+hepatocellular+carcinoma+with+major+portal+or+hepatic+vein+invasion:+results+of+a+multicenter+studyen_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailOiLin Ng, I: iolng@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityOiLin Ng, I=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.surg.2004.12.012en_HK
dc.identifier.pmid15800485-
dc.identifier.scopuseid_2-s2.0-20144388983en_HK
dc.identifier.hkuros99724en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20144388983&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume137en_HK
dc.identifier.issue4en_HK
dc.identifier.spage403en_HK
dc.identifier.epage410en_HK
dc.identifier.isiWOS:000228241300003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPawlik, TM=7006249269en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridAbdalla, EK=7006112354en_HK
dc.identifier.scopusauthoridIkai, I=7006764463en_HK
dc.identifier.scopusauthoridNagorney, DM=35400419300en_HK
dc.identifier.scopusauthoridBelghiti, J=35403099400en_HK
dc.identifier.scopusauthoridKianmanesh, R=6701430799en_HK
dc.identifier.scopusauthoridOiLin Ng, I=7102753722en_HK
dc.identifier.scopusauthoridCurley, SA=7006597814en_HK
dc.identifier.scopusauthoridYamaoka, Y=7201994050en_HK
dc.identifier.scopusauthoridLauwers, GY=35391239300en_HK
dc.identifier.scopusauthoridVauthey, JN=35270590000en_HK

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