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Article: Exogenous expression of p21WAF1/CIP1 exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells

TitleExogenous expression of p21WAF1/CIP1 exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells
Authors
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2001, v. 172 n. 1, p. 7-15 How to Cite?
AbstractThe effects of exogenous expression of p21WAF1/CIP1 in hepatoma cells were examined. Two stably p21WAF1/CIP1-transfected clones and one clone transfected with expression vector only were used for study. Introduction of p21WAF1/CIP1 resulted in significant cell growth inhibition, and the magnitude of the cell growth inhibition in these transfected cells was proportional to the level of p21WAF1/CIP1 protein expressed. Exogenous p21WAF1/CIP1 expression also significantly enhanced chemosensitivity to cisplatin. In addition, apoptosis occurred earlier in cells transfected with p21WAF1/CIP1 after cisplatin treatment. These findings raise the potential that forced upregulation of p21WAF1/CIP1 in hepatocellular carcinoma (HCC) may reduce the doses of cisplatin to achieve similar responses and suggest the possible use of p21WAF1/CIP1 in HCC treatment. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/88643
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQin, LFen_HK
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-09-06T09:46:04Z-
dc.date.available2010-09-06T09:46:04Z-
dc.date.issued2001en_HK
dc.identifier.citationCancer Letters, 2001, v. 172 n. 1, p. 7-15en_HK
dc.identifier.issn0304-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88643-
dc.description.abstractThe effects of exogenous expression of p21WAF1/CIP1 in hepatoma cells were examined. Two stably p21WAF1/CIP1-transfected clones and one clone transfected with expression vector only were used for study. Introduction of p21WAF1/CIP1 resulted in significant cell growth inhibition, and the magnitude of the cell growth inhibition in these transfected cells was proportional to the level of p21WAF1/CIP1 protein expressed. Exogenous p21WAF1/CIP1 expression also significantly enhanced chemosensitivity to cisplatin. In addition, apoptosis occurred earlier in cells transfected with p21WAF1/CIP1 after cisplatin treatment. These findings raise the potential that forced upregulation of p21WAF1/CIP1 in hepatocellular carcinoma (HCC) may reduce the doses of cisplatin to achieve similar responses and suggest the possible use of p21WAF1/CIP1 in HCC treatment. © 2001 Elsevier Science Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_HK
dc.relation.ispartofCancer Lettersen_HK
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAntineoplastic Agents - pharmacologyen_HK
dc.subject.meshBlotting, Westernen_HK
dc.subject.meshCarcinoma, Hepatocellular - drug therapyen_HK
dc.subject.meshCell Cycle - drug effectsen_HK
dc.subject.meshCell Division - drug effectsen_HK
dc.subject.meshCisplatin - pharmacologyen_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p21en_HK
dc.subject.meshCyclins - biosynthesisen_HK
dc.subject.meshDNA Fragmentationen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshGenes, p53 - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - drug therapyen_HK
dc.subject.meshTetrazolium Salts - pharmacologyen_HK
dc.subject.meshThiazoles - pharmacologyen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.titleExogenous expression of p21WAF1/CIP1 exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=172&spage=7&epage=15&date=2001&atitle=Exogenous+expression+of+p21WAF1/CIP1+exerts+cell+growth+inhibition+and+enhances+sensitivity+to+cisplatin+in+hepatoma+cellsen_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0304-3835(01)00701-7en_HK
dc.identifier.pmid11595124en_HK
dc.identifier.scopuseid_2-s2.0-0035935259en_HK
dc.identifier.hkuros63378en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035935259&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume172en_HK
dc.identifier.issue1en_HK
dc.identifier.spage7en_HK
dc.identifier.epage15en_HK
dc.identifier.isiWOS:000171238900002-
dc.publisher.placeIrelanden_HK

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