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Article: Pathologic features and patient survival in hepatocellular carcinoma in relation to age

TitlePathologic features and patient survival in hepatocellular carcinoma in relation to age
Authors
Keywordsage
clinicopathologic features
hepatocellular carcinoma
patient survival
Issue Date1996
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31873
Citation
Journal Of Surgical Oncology, 1996, v. 61 n. 2, p. 134-137 How to Cite?
AbstractFor hepatocellular carcinoma, the peak age of patients is at the sixth decade. However, the influence of age on the tumor biologic behavior and long-term patient survival is controversial. We retrospectively studied 278 patients whose hepatocellular carcinomas were surgically resected to analyze the pathologic and clinical features of the tumors and patient survival in relation to age. The patients were divided into two groups, younger than 50 years of age and older than 50 years. Ninety-seven patients were 50 years of age or under, and 181 were older than 50 years. The younger patients had: (1) more frequent hepatitis B surface antigen positivity (P = 0.022), (2) less cirrhosis (P = 0.050), (3) less tumor encapsulation, (4) a more advanced tumor stage in terms of more venous permeation (P = 0.012), more liver invasion (P = 0.010) and larger tumor (P = 0.002), and (5) a more frequently raised serum alpha-fetoprotein level (P = 0.035). In spite of the more advanced stage of the tumors, both the actuarial and disease-free survival rates did not differ significantly from those of the older group. The operative mortality rates also were similar in both groups. To conclude, there were distinct differences in the clinical and pathologic features of the tumors of patients <50 years and those older. Although the tumors were more advanced in the younger group, the less frequently associated cirrhosis in this group might have partly compensated to result in survival rates similar to those of the older group. Because of the comparable survival rates, the treatment policy in the older group should not differ greatly from that in the younger group.
Persistent Identifierhttp://hdl.handle.net/10722/88634
ISSN
2015 Impact Factor: 3.151
2015 SCImago Journal Rankings: 1.349
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorNg, Men_HK
dc.contributor.authorLai, ECSen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T09:45:57Z-
dc.date.available2010-09-06T09:45:57Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Surgical Oncology, 1996, v. 61 n. 2, p. 134-137en_HK
dc.identifier.issn0022-4790en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88634-
dc.description.abstractFor hepatocellular carcinoma, the peak age of patients is at the sixth decade. However, the influence of age on the tumor biologic behavior and long-term patient survival is controversial. We retrospectively studied 278 patients whose hepatocellular carcinomas were surgically resected to analyze the pathologic and clinical features of the tumors and patient survival in relation to age. The patients were divided into two groups, younger than 50 years of age and older than 50 years. Ninety-seven patients were 50 years of age or under, and 181 were older than 50 years. The younger patients had: (1) more frequent hepatitis B surface antigen positivity (P = 0.022), (2) less cirrhosis (P = 0.050), (3) less tumor encapsulation, (4) a more advanced tumor stage in terms of more venous permeation (P = 0.012), more liver invasion (P = 0.010) and larger tumor (P = 0.002), and (5) a more frequently raised serum alpha-fetoprotein level (P = 0.035). In spite of the more advanced stage of the tumors, both the actuarial and disease-free survival rates did not differ significantly from those of the older group. The operative mortality rates also were similar in both groups. To conclude, there were distinct differences in the clinical and pathologic features of the tumors of patients <50 years and those older. Although the tumors were more advanced in the younger group, the less frequently associated cirrhosis in this group might have partly compensated to result in survival rates similar to those of the older group. Because of the comparable survival rates, the treatment policy in the older group should not differ greatly from that in the younger group.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31873en_HK
dc.relation.ispartofJournal of Surgical Oncologyen_HK
dc.rightsJournal of Surgical Oncology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectageen_HK
dc.subjectclinicopathologic featuresen_HK
dc.subjecthepatocellular carcinomaen_HK
dc.subjectpatient survivalen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshCarcinoma, Hepatocellular - mortality - pathology - surgery - virologyen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B Surface Antigens - analysisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - mortality - pathology - surgery - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSurvival Rateen_HK
dc.titlePathologic features and patient survival in hepatocellular carcinoma in relation to ageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-4790&volume=61&spage=134&epage=137&date=1996&atitle=Pathologic+features+and+patient+survival+in+hepatocellular+carcinoma+in+relation+to+ageen_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1096-9098(199602)61:2<134::AID-JSO8>3.0.CO;2-Den_HK
dc.identifier.pmid8606545-
dc.identifier.scopuseid_2-s2.0-0030022597en_HK
dc.identifier.hkuros12226en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030022597&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue2en_HK
dc.identifier.spage134en_HK
dc.identifier.epage137en_HK
dc.identifier.isiWOS:A1996TV76300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridNg, M=7202076310en_HK
dc.identifier.scopusauthoridLai, ECS=55187481700en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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