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Article: In situ detection of Epstein-Barr virus in gastric and colorectal adenocarcinomas

TitleIn situ detection of Epstein-Barr virus in gastric and colorectal adenocarcinomas
Authors
Issue Date1994
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 1994, v. 18 n. 11, p. 1158-1163 How to Cite?
AbstractThe association of Epstein-Barr virus (EBV) with lymphoepithelioma-like carcinoma in the nasopharynx, which is common in Chinese from the southern region, is well established. Recently, EBV has also been found to be associated with lymphoepithelioma-like carcinomas (LELCs) and carcinomas with prominent lymphoid infiltrates in the stomach. We investigated for the presence of EBV in 74 cases of gastric adenocarcinoma and 36 cases of colorectal adenocarcinoma from Chinese patients by in situ hybridization (ISH) using an antisense EBER probe. In seven cases (9.5%) of gastric carcinoma, EBER was highly expressed in the adenocarcinoma cells and metastatic tumor cells in regional lymph nodes. In all these cases, the normal gastric epithelium was EBV negative. None of the colorectal carcinomas showed a positive signal. Isolated positive lymphoid cells were frequently found in both tumors. Of the seven positive cases, only one was LELC, and the others were conventional adenocarcinomas of the intestinal type. Five showed expression of the viral RNA in all tumor cells as well as the surrounding dysplastic epithelium. Interestingly, the sixth case showed distinct negative islands of dysplastic glands adjacent to strongly positive dysplastic glands and invasive carcinoma cells. This pattern of positivity, together with negative normal gastric epithelium and positive metastatic tumor, suggested that EBV infection occurred in the dysplastic phase and that an apparent growth advantage was conferred by the EBV infection.
Persistent Identifierhttp://hdl.handle.net/10722/88614
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuen, STen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorLuk, ISCen_HK
dc.contributor.authorChan, SYen_HK
dc.contributor.authorHo, Jen_HK
dc.date.accessioned2010-09-06T09:45:41Z-
dc.date.available2010-09-06T09:45:41Z-
dc.date.issued1994en_HK
dc.identifier.citationAmerican Journal Of Surgical Pathology, 1994, v. 18 n. 11, p. 1158-1163en_HK
dc.identifier.issn0147-5185en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88614-
dc.description.abstractThe association of Epstein-Barr virus (EBV) with lymphoepithelioma-like carcinoma in the nasopharynx, which is common in Chinese from the southern region, is well established. Recently, EBV has also been found to be associated with lymphoepithelioma-like carcinomas (LELCs) and carcinomas with prominent lymphoid infiltrates in the stomach. We investigated for the presence of EBV in 74 cases of gastric adenocarcinoma and 36 cases of colorectal adenocarcinoma from Chinese patients by in situ hybridization (ISH) using an antisense EBER probe. In seven cases (9.5%) of gastric carcinoma, EBER was highly expressed in the adenocarcinoma cells and metastatic tumor cells in regional lymph nodes. In all these cases, the normal gastric epithelium was EBV negative. None of the colorectal carcinomas showed a positive signal. Isolated positive lymphoid cells were frequently found in both tumors. Of the seven positive cases, only one was LELC, and the others were conventional adenocarcinomas of the intestinal type. Five showed expression of the viral RNA in all tumor cells as well as the surrounding dysplastic epithelium. Interestingly, the sixth case showed distinct negative islands of dysplastic glands adjacent to strongly positive dysplastic glands and invasive carcinoma cells. This pattern of positivity, together with negative normal gastric epithelium and positive metastatic tumor, suggested that EBV infection occurred in the dysplastic phase and that an apparent growth advantage was conferred by the EBV infection.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_HK
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_HK
dc.rightsAmerican Journal of Surgical Pathology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAdenocarcinoma - pathology - virologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshColorectal Neoplasms - pathology - virologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHerpesviridae Infections - diagnosisen_HK
dc.subject.meshHerpesvirus 4, Human - isolation & purificationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshStomach Neoplasms - pathology - virologyen_HK
dc.subject.meshTumor Virus Infections - diagnosisen_HK
dc.titleIn situ detection of Epstein-Barr virus in gastric and colorectal adenocarcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-5185&volume=18&spage=1158&epage=1163&date=1994&atitle=In+situ+detection+of+Epstein-Barr+virus+in+gastric+and+colorectal+adenocarcinomasen_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7943537-
dc.identifier.scopuseid_2-s2.0-0028099493en_HK
dc.identifier.hkuros5060en_HK
dc.identifier.volume18en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1158en_HK
dc.identifier.epage1163en_HK
dc.identifier.isiWOS:A1994PN36800009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridLuk, ISC=6603553769en_HK
dc.identifier.scopusauthoridChan, SY=7404255845en_HK
dc.identifier.scopusauthoridHo, J=15029093800en_HK

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