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Article: A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

TitleA screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Authors
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2005, v. 37 n. 6, p. 590-592 How to Cite?
AbstractWe examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
Persistent Identifierhttp://hdl.handle.net/10722/88572
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorStephens, Pen_HK
dc.contributor.authorEdkins, Sen_HK
dc.contributor.authorDavies, Hen_HK
dc.contributor.authorGreenman, Cen_HK
dc.contributor.authorCox, Cen_HK
dc.contributor.authorHunter, Cen_HK
dc.contributor.authorBignell, Gen_HK
dc.contributor.authorTeague, Jen_HK
dc.contributor.authorSmith, Ren_HK
dc.contributor.authorStevens, Cen_HK
dc.contributor.authorO'Meara, Sen_HK
dc.contributor.authorParker, Aen_HK
dc.contributor.authorTarpey, Pen_HK
dc.contributor.authorAvis, Ten_HK
dc.contributor.authorBarthorpe, Aen_HK
dc.contributor.authorBrackenbury, Len_HK
dc.contributor.authorBuck, Gen_HK
dc.contributor.authorButler, Aen_HK
dc.contributor.authorClements, Jen_HK
dc.contributor.authorCole, Jen_HK
dc.contributor.authorDicks, Een_HK
dc.contributor.authorEdwards, Ken_HK
dc.contributor.authorForbes, Sen_HK
dc.contributor.authorGorton, Men_HK
dc.contributor.authorGray, Ken_HK
dc.contributor.authorHalliday, Ken_HK
dc.contributor.authorHarrison, Ren_HK
dc.contributor.authorHills, Ken_HK
dc.contributor.authorHinton, Jen_HK
dc.contributor.authorJones, Den_HK
dc.contributor.authorKosmidou, Ven_HK
dc.contributor.authorLaman, Ren_HK
dc.contributor.authorLugg, Ren_HK
dc.contributor.authorMenzies, Aen_HK
dc.contributor.authorPerry, Jen_HK
dc.contributor.authorPetty, Ren_HK
dc.contributor.authorRaine, Ken_HK
dc.contributor.authorShepherd, Ren_HK
dc.contributor.authorSmall, Aen_HK
dc.contributor.authorSolomon, Hen_HK
dc.contributor.authorStephens, Yen_HK
dc.contributor.authorTofts, Cen_HK
dc.contributor.authorVarian, Jen_HK
dc.contributor.authorWebb, Aen_HK
dc.contributor.authorWest, Sen_HK
dc.contributor.authorWidaa, Sen_HK
dc.contributor.authorYates, Aen_HK
dc.contributor.authorBrasseur, Fen_HK
dc.contributor.authorCooper, CSen_HK
dc.contributor.authorFlanagan, AMen_HK
dc.contributor.authorGreen, Aen_HK
dc.contributor.authorKnowles, Men_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorLooijenga, LHJen_HK
dc.contributor.authorMalkowicz, Ben_HK
dc.contributor.authorPierotti, MAen_HK
dc.contributor.authorTeh, Ben_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorNicholson, AGen_HK
dc.contributor.authorLakhani, Sen_HK
dc.contributor.authorEaston, DFen_HK
dc.contributor.authorWeber, BLen_HK
dc.contributor.authorStratton, MRen_HK
dc.contributor.authorFutreal, PAen_HK
dc.contributor.authorWooster, Ren_HK
dc.date.accessioned2010-09-06T09:45:08Z-
dc.date.available2010-09-06T09:45:08Z-
dc.date.issued2005en_HK
dc.identifier.citationNature Genetics, 2005, v. 37 n. 6, p. 590-592en_HK
dc.identifier.issn1061-4036en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88572-
dc.description.abstractWe examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_HK
dc.relation.ispartofNature Geneticsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshBreast Neoplasms - geneticsen_HK
dc.subject.meshCarcinoma, Ductal, Breast - geneticsen_HK
dc.subject.meshDNA Mutational Analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMultigene Familyen_HK
dc.subject.meshMutationen_HK
dc.subject.meshProtein Kinases - geneticsen_HK
dc.titleA screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1061-4036&volume=37&issue=6&spage=590&epage=592&date=2005&atitle=A+screen+of+the+complete+protein+kinase+gene+family+identifies+diverse+patterns+of+somatic+mutations+in+human+breast+canceren_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng1571en_HK
dc.identifier.pmid15908952-
dc.identifier.scopuseid_2-s2.0-20044381123en_HK
dc.identifier.hkuros108402en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20044381123&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue6en_HK
dc.identifier.spage590en_HK
dc.identifier.epage592en_HK
dc.identifier.isiWOS:000229495300011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001027794-
dc.identifier.citeulike212291-

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