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Article: Pathological prognostic factors in hepatocellular carcinoma

TitlePathological prognostic factors in hepatocellular carcinoma
Authors
KeywordsDNA ploidy
hepatocellular carcinoma
p53 gene
pathology
prognosis
proliferation indices
Issue Date1996
Citation
Cancer Journal, 1996, v. 9 n. 5, p. 226-228 How to Cite?
AbstractRelevant studies on the pathological factors of hepatocellular carcinoma in relation to prognosis are reviewed. Morphological features of the tumour, both gross and histological, have been found to be significantly related to tumour recurrence and patient survival. Recently, with applications of newer antibodies and techniques, studies on cellular proliferation activities using proliferating cell nuclear antigen and Ki-67 antibodies, and assessment of argyrophilic nucleolar organizing regions have been shown to provide good prognostic significance. Flow cytometric studies on DNA ploidy and studies on expression of genes, particularly p53 tumour suppressor gene, are also reviewed, but the results are less unanimous. In conclusion, these pathological prognostic factors help to guide the clinicians in the management of patients and in assessment of long-term prognosis.
Persistent Identifierhttp://hdl.handle.net/10722/88543
ISSN
1999 Impact Factor: 0.52
2015 SCImago Journal Rankings: 1.973

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-09-06T09:44:44Z-
dc.date.available2010-09-06T09:44:44Z-
dc.date.issued1996en_HK
dc.identifier.citationCancer Journal, 1996, v. 9 n. 5, p. 226-228en_HK
dc.identifier.issn0765-7846en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88543-
dc.description.abstractRelevant studies on the pathological factors of hepatocellular carcinoma in relation to prognosis are reviewed. Morphological features of the tumour, both gross and histological, have been found to be significantly related to tumour recurrence and patient survival. Recently, with applications of newer antibodies and techniques, studies on cellular proliferation activities using proliferating cell nuclear antigen and Ki-67 antibodies, and assessment of argyrophilic nucleolar organizing regions have been shown to provide good prognostic significance. Flow cytometric studies on DNA ploidy and studies on expression of genes, particularly p53 tumour suppressor gene, are also reviewed, but the results are less unanimous. In conclusion, these pathological prognostic factors help to guide the clinicians in the management of patients and in assessment of long-term prognosis.en_HK
dc.languageengen_HK
dc.relation.ispartofCancer Journalen_HK
dc.subjectDNA ploidyen_HK
dc.subjecthepatocellular carcinomaen_HK
dc.subjectp53 geneen_HK
dc.subjectpathologyen_HK
dc.subjectprognosisen_HK
dc.subjectproliferation indicesen_HK
dc.titlePathological prognostic factors in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0029850093en_HK
dc.identifier.hkuros25904en_HK
dc.identifier.volume9en_HK
dc.identifier.issue5en_HK
dc.identifier.spage226en_HK
dc.identifier.epage228en_HK

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