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Article: Microsatellite analysis in post-transplantation lymphoproliferative disorder to determine donor/recipient origin

TitleMicrosatellite analysis in post-transplantation lymphoproliferative disorder to determine donor/recipient origin
Authors
KeywordsDonor/recipient origin
Microsatellite analysis
Post-transplantation lymphoproliferative disorder
Issue Date2000
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
Citation
Modern Pathology, 2000, v. 13 n. 11, p. 1180-1185 How to Cite?
AbstractPost-transplantation lymphoproliferative disorders (PTLD) are a group of heterogeneous diseases that occur after organ transplantation. Determination of the origin of the tumor cells not only provides clues to its possible pathogenetic mechanism, but also gives prognostic guidance in the clinical management of patients. We reviewed the clinicopathological features of four cases of PTLD that developed after solid organ transplantation. Using microsatellite analysis performed on paraffin-embedded tissue and using multiple, highly polymorphic markers, we have successfully determined the recipient/donor origin of the tumor cells in all of them. The time of onset of the PTLD ranged from 5 to 11 mo. All cases were diffuse large cell lymphomas of B-cell lineage, and the two cases that have been tested for EBV by in situ hybridization were positive. Three of the 4 PTLD were of donor origin and these three patients died of diseases unrelated to PTLD. The single patient with PTLD of recipient origin died of disseminated PTLD. The mean survival length of the three patients with donor origin was 26.3 mo, whereas that of the patient with recipient origin was 12 mo. Our results indicate a relatively high incidence of PTLD of donor origin among our patients with solid organ transplantation, as compared to other reported series. Moreover, the finding of the relatively indolent nature of PTLD of donor origin supports that determination of the donor/recipient origin of PTLD is of prognostic significance.
Persistent Identifierhttp://hdl.handle.net/10722/88536
ISSN
2015 Impact Factor: 5.485
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorThung, SNen_HK
dc.contributor.authorYe, MMQen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLee, JMFen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T09:44:38Z-
dc.date.available2010-09-06T09:44:38Z-
dc.date.issued2000en_HK
dc.identifier.citationModern Pathology, 2000, v. 13 n. 11, p. 1180-1185en_HK
dc.identifier.issn0893-3952en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88536-
dc.description.abstractPost-transplantation lymphoproliferative disorders (PTLD) are a group of heterogeneous diseases that occur after organ transplantation. Determination of the origin of the tumor cells not only provides clues to its possible pathogenetic mechanism, but also gives prognostic guidance in the clinical management of patients. We reviewed the clinicopathological features of four cases of PTLD that developed after solid organ transplantation. Using microsatellite analysis performed on paraffin-embedded tissue and using multiple, highly polymorphic markers, we have successfully determined the recipient/donor origin of the tumor cells in all of them. The time of onset of the PTLD ranged from 5 to 11 mo. All cases were diffuse large cell lymphomas of B-cell lineage, and the two cases that have been tested for EBV by in situ hybridization were positive. Three of the 4 PTLD were of donor origin and these three patients died of diseases unrelated to PTLD. The single patient with PTLD of recipient origin died of disseminated PTLD. The mean survival length of the three patients with donor origin was 26.3 mo, whereas that of the patient with recipient origin was 12 mo. Our results indicate a relatively high incidence of PTLD of donor origin among our patients with solid organ transplantation, as compared to other reported series. Moreover, the finding of the relatively indolent nature of PTLD of donor origin supports that determination of the donor/recipient origin of PTLD is of prognostic significance.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/en_HK
dc.relation.ispartofModern Pathologyen_HK
dc.subjectDonor/recipient originen_HK
dc.subjectMicrosatellite analysisen_HK
dc.subjectPost-transplantation lymphoproliferative disorderen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshDNA - analysisen_HK
dc.subject.meshDisease Transmission, Infectiousen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphoma, B-Cell - etiology - genetics - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrosatellite Repeatsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOrgan Transplantation - adverse effects - pathologyen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPostoperative Complications - etiology - pathologyen_HK
dc.subject.meshTissue Donorsen_HK
dc.titleMicrosatellite analysis in post-transplantation lymphoproliferative disorder to determine donor/recipient originen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0893-3952&volume=13&issue=11&spage=1180&epage=1185&date=2000&atitle=Microsatellite+analysis+in+post-transplantation+lymphoproliferative+disorder+to+determine+donor/recipient+originen_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11106074-
dc.identifier.scopuseid_2-s2.0-0033680294en_HK
dc.identifier.hkuros56458en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033680294&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1180en_HK
dc.identifier.epage1185en_HK
dc.identifier.isiWOS:000165570500004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridShek, TWH=7005479861en_HK
dc.identifier.scopusauthoridThung, SN=35392441200en_HK
dc.identifier.scopusauthoridYe, MMQ=19640841000en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLee, JMF=36065603500en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK

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