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Article: Clinicopathologic and prognostic significance of the histologic activity of noncancerous liver tissue in hepatitis B virus-associated hepatocellular carcinoma

TitleClinicopathologic and prognostic significance of the histologic activity of noncancerous liver tissue in hepatitis B virus-associated hepatocellular carcinoma
Authors
KeywordsHepatitis B
Hepatocellular carcinoma
Histologic activity index
Prognosis
Issue Date2002
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 2002, v. 117 n. 3, p. 411-418 How to Cite?
AbstractWe prospectively studied 66 patients infected with the hepatitis B virus who underwent liver resection for hepatocellular carcinoma (HCC) to evaluate the influence of the histologic activity of noncancerous liver tissue on clinicopathologic features and prognosis. Based on the histologic activity index (HAI) score of nontumorous liver tissue, patients were classified into 3 groups: mild, moderate, or severe hepatitis. Overall, higher HAI scores were more frequent in patients with poorer liver function: lower serum albumin levels and higher indocyanine green retention at 15 minutes. Moreover, patients with moderate hepatitis had more frequent venous invasion, and the tumor size decreased with increasing HAI scores. Similar results were observed when the fibrosis category was excluded in the calculation of HAI scores. The overall or disease-free survival rates did not differ significantly among the 3 groups of patients. However, higher fibrosis scores were associated significantly with shorter disease-free survival rates. HAI scores correlated significantly with certain clinicopathologic features. In patients with hepatitis B-related HCC, a higher fibrosis score in the nontumorous liver tissue, but not histologic hepatitic activity, seems to be a significant factor predisposing to shorter survival.
Persistent Identifierhttp://hdl.handle.net/10722/88477
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T09:43:53Z-
dc.date.available2010-09-06T09:43:53Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Clinical Pathology, 2002, v. 117 n. 3, p. 411-418en_HK
dc.identifier.issn0002-9173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88477-
dc.description.abstractWe prospectively studied 66 patients infected with the hepatitis B virus who underwent liver resection for hepatocellular carcinoma (HCC) to evaluate the influence of the histologic activity of noncancerous liver tissue on clinicopathologic features and prognosis. Based on the histologic activity index (HAI) score of nontumorous liver tissue, patients were classified into 3 groups: mild, moderate, or severe hepatitis. Overall, higher HAI scores were more frequent in patients with poorer liver function: lower serum albumin levels and higher indocyanine green retention at 15 minutes. Moreover, patients with moderate hepatitis had more frequent venous invasion, and the tumor size decreased with increasing HAI scores. Similar results were observed when the fibrosis category was excluded in the calculation of HAI scores. The overall or disease-free survival rates did not differ significantly among the 3 groups of patients. However, higher fibrosis scores were associated significantly with shorter disease-free survival rates. HAI scores correlated significantly with certain clinicopathologic features. In patients with hepatitis B-related HCC, a higher fibrosis score in the nontumorous liver tissue, but not histologic hepatitic activity, seems to be a significant factor predisposing to shorter survival.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_HK
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_HK
dc.subjectHepatitis Ben_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectHistologic activity indexen_HK
dc.subjectPrognosisen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAlanine Transaminase - blooden_HK
dc.subject.meshAspartate Aminotransferases - blooden_HK
dc.subject.meshCarcinoma, Hepatocellular - mortality - pathology - virologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - pathologyen_HK
dc.subject.meshLiver Cirrhosis - pathologyen_HK
dc.subject.meshLiver Neoplasms - mortality - pathology - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshSerum Albumin - analysisen_HK
dc.subject.meshSurvival Rateen_HK
dc.titleClinicopathologic and prognostic significance of the histologic activity of noncancerous liver tissue in hepatitis B virus-associated hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9173&volume=117&spage=411&epage=418&date=2002&atitle=Clinicopathologic+and+prognostic+significance+of+the+histologic+activity+of+noncancerous+liver+tissue+in+hepatitis+B+virus-associated+hepatocellular+carcinomaen_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1309/4231-RCVB-WK8X-R1JKen_HK
dc.identifier.pmid11892725-
dc.identifier.scopuseid_2-s2.0-0036126123en_HK
dc.identifier.hkuros68697en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036126123&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume117en_HK
dc.identifier.issue3en_HK
dc.identifier.spage411en_HK
dc.identifier.epage418en_HK
dc.identifier.isiWOS:000174186300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridShek, TWH=7005479861en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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