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Article: Biologic markers in breast cancer: An update

TitleBiologic markers in breast cancer: An update
Authors
KeywordsAdhesion molecules
Cytoskeletal proteins
Immunohistochemistry
Prognosis
Vimentin
Issue Date1998
PublisherNational Society for Histotechnology. The Journal's web site is located at http://www.nsh.org/pubs/TofC.html
Citation
Journal Of Histotechnology, 1998, v. 21 n. 4, p. 317-325 How to Cite?
AbstractThe ability to diagnosis breast cancer at an earlier stage and the development of a wider range of treatment options have stimulated the search for more refined criteria to select the subgroup of patients who develop recurrent disease despite the absence of nodal involvement at the time of tumor resection. Such criteria include biologic parameters of prognostic relevance, especially those that can be applied to routinely processed tissue sections, as they allow a correlation with established histologic features of prognostic relevance. The biologic parameters can be divided into those which are intrinsic characteristics of the tumors cells and those related to the interaction of tumor and the immediate microenvironment, the latter factors influencing invasiveness and metastatic potential. Steroid hormone receptor expression, tumor growth fraction estimation, growth factors and their receptors, and tumor suppressor gene proteins can now be assessed by immunostaining of routinely processed tissue sections. Whereas the assessment of other parameters such as bcl-2 and Bax proteins, nm23 metastasis suppressor gene expression, vimentin, and other genes related to cyclin- dependent kinase activity can also he done immunohistochemically, their worthiness as prognostic parameters require further studies. Factors related to tumor-stromal interaction include angiogenesis, adhesion molecules, cytoskeletal proteins, extracellular matrix proteins and proteases, all of which are potentially useful prognostic indices and also hold promise for newer avenues of therapeutic intervention.
Persistent Identifierhttp://hdl.handle.net/10722/88475
ISSN
2015 Impact Factor: 0.086
2015 SCImago Journal Rankings: 0.107

 

DC FieldValueLanguage
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorLeong, ASYen_HK
dc.date.accessioned2010-09-06T09:43:52Z-
dc.date.available2010-09-06T09:43:52Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Histotechnology, 1998, v. 21 n. 4, p. 317-325en_HK
dc.identifier.issn0147-8885en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88475-
dc.description.abstractThe ability to diagnosis breast cancer at an earlier stage and the development of a wider range of treatment options have stimulated the search for more refined criteria to select the subgroup of patients who develop recurrent disease despite the absence of nodal involvement at the time of tumor resection. Such criteria include biologic parameters of prognostic relevance, especially those that can be applied to routinely processed tissue sections, as they allow a correlation with established histologic features of prognostic relevance. The biologic parameters can be divided into those which are intrinsic characteristics of the tumors cells and those related to the interaction of tumor and the immediate microenvironment, the latter factors influencing invasiveness and metastatic potential. Steroid hormone receptor expression, tumor growth fraction estimation, growth factors and their receptors, and tumor suppressor gene proteins can now be assessed by immunostaining of routinely processed tissue sections. Whereas the assessment of other parameters such as bcl-2 and Bax proteins, nm23 metastasis suppressor gene expression, vimentin, and other genes related to cyclin- dependent kinase activity can also he done immunohistochemically, their worthiness as prognostic parameters require further studies. Factors related to tumor-stromal interaction include angiogenesis, adhesion molecules, cytoskeletal proteins, extracellular matrix proteins and proteases, all of which are potentially useful prognostic indices and also hold promise for newer avenues of therapeutic intervention.en_HK
dc.languageengen_HK
dc.publisherNational Society for Histotechnology. The Journal's web site is located at http://www.nsh.org/pubs/TofC.htmlen_HK
dc.relation.ispartofJournal of Histotechnologyen_HK
dc.subjectAdhesion moleculesen_HK
dc.subjectCytoskeletal proteinsen_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectPrognosisen_HK
dc.subjectVimentinen_HK
dc.titleBiologic markers in breast cancer: An updateen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-8885&volume=21&issue=4&spage=317&epage=325&date=1998&atitle=Biologic+markers+in+breast+cancer:+An+updateen_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1179/his.1998.21.4.317-
dc.identifier.scopuseid_2-s2.0-0032420760en_HK
dc.identifier.hkuros40698en_HK
dc.identifier.volume21en_HK
dc.identifier.issue4en_HK
dc.identifier.spage317en_HK
dc.identifier.epage325en_HK
dc.publisher.placeUnited Statesen_HK

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