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Article: N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation

TitleN-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation
Authors
KeywordsCell proliferation
Gene expression
Glioblastoma
HNDRG2
U373
Issue Date2003
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2003, v. 106 n. 3, p. 342-347 How to Cite?
AbstractThe most severe form of brain glioma, glioblastoma (GBM), is highly malignant and usually resistant to chemotherapy. Therefore, discovery of new targets for gene therapy is important. Using subtraction cloning, we identified the human N-Myc downstream-regulated gene 2 (hNDRG2), located at chromosome 14q11.2, as a gene that is significantly suppressed in GBM tissues. Semiquantitative RT-PCR showed that the hNDRG2 gene transcript is expressed in normal brain tissue and low-grade gliomas but is present at low levels in 15 of 27 (56%) human GBM tissues and all of the 6 human glioblastoma cell lines examined. Furthermore, transfection of human glioblastoma U373 and U138 cells with a cDNA encoding hNDRG2 markedly reduced the cell proliferation. Our findings provide the first evidence to suggest that hNDRG2 may play a role in glioblastoma carcinogenesis. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/88468
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDeng, Yen_HK
dc.contributor.authorYao, Len_HK
dc.contributor.authorChau, Len_HK
dc.contributor.authorNg, SSMen_HK
dc.contributor.authorPeng, Yen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorAu, WSen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorLi, Fen_HK
dc.contributor.authorJi, Sen_HK
dc.contributor.authorHan, Hen_HK
dc.contributor.authorNie, Xen_HK
dc.contributor.authorLi, Qen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorLin, MCMen_HK
dc.date.accessioned2010-09-06T09:43:47Z-
dc.date.available2010-09-06T09:43:47Z-
dc.date.issued2003en_HK
dc.identifier.citationInternational Journal Of Cancer, 2003, v. 106 n. 3, p. 342-347en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88468-
dc.description.abstractThe most severe form of brain glioma, glioblastoma (GBM), is highly malignant and usually resistant to chemotherapy. Therefore, discovery of new targets for gene therapy is important. Using subtraction cloning, we identified the human N-Myc downstream-regulated gene 2 (hNDRG2), located at chromosome 14q11.2, as a gene that is significantly suppressed in GBM tissues. Semiquantitative RT-PCR showed that the hNDRG2 gene transcript is expressed in normal brain tissue and low-grade gliomas but is present at low levels in 15 of 27 (56%) human GBM tissues and all of the 6 human glioblastoma cell lines examined. Furthermore, transfection of human glioblastoma U373 and U138 cells with a cDNA encoding hNDRG2 markedly reduced the cell proliferation. Our findings provide the first evidence to suggest that hNDRG2 may play a role in glioblastoma carcinogenesis. © 2003 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectCell proliferationen_HK
dc.subjectGene expressionen_HK
dc.subjectGlioblastomaen_HK
dc.subjectHNDRG2en_HK
dc.subjectU373en_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshBlotting, Northernen_HK
dc.subject.meshBrain Neoplasms - genetics - metabolism - pathologyen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshChromosomes, Human, Pair 14 - genetics - metabolismen_HK
dc.subject.meshDNA, Complementary - chemistry - isolation & purification - metabolismen_HK
dc.subject.meshDown-Regulationen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshGlioblastoma - genetics - metabolism - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshNeoplasm Proteins - genetics - metabolismen_HK
dc.subject.meshProteins - geneticsen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRNA, Neoplasm - genetics - metabolismen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTissue Distributionen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshTumor Cells, Cultured - metabolism - pathologyen_HK
dc.subject.meshTumor Markers, Biological - genetics - metabolismen_HK
dc.subject.meshTumor Suppressor Proteinsen_HK
dc.titleN-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=106&spage=342&epage=347&date=2003&atitle=N-MYC+downstream-regulated+gene+2+(NDRG2)+inhibits+glioblastoma+cell+proliferationen_HK
dc.identifier.emailNg, SSM: ssmng@hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailLin, MCM: mcllin@hkucc.hku.hken_HK
dc.identifier.authorityNg, SSM=rp00767en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ijc.11228en_HK
dc.identifier.pmid12845671-
dc.identifier.scopuseid_2-s2.0-0037491744en_HK
dc.identifier.hkuros79111en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037491744&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume106en_HK
dc.identifier.issue3en_HK
dc.identifier.spage342en_HK
dc.identifier.epage347en_HK
dc.identifier.isiWOS:000184277500007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDeng, Y=7401531039en_HK
dc.identifier.scopusauthoridYao, L=7201688467en_HK
dc.identifier.scopusauthoridChau, L=7102672305en_HK
dc.identifier.scopusauthoridNg, SSM=7403358718en_HK
dc.identifier.scopusauthoridPeng, Y=7403419265en_HK
dc.identifier.scopusauthoridLiu, X=8572202600en_HK
dc.identifier.scopusauthoridAu, WS=7202383097en_HK
dc.identifier.scopusauthoridWang, J=8630585100en_HK
dc.identifier.scopusauthoridLi, F=7406057562en_HK
dc.identifier.scopusauthoridJi, S=7202228863en_HK
dc.identifier.scopusauthoridHan, H=7401969486en_HK
dc.identifier.scopusauthoridNie, X=7103207437en_HK
dc.identifier.scopusauthoridLi, Q=36067406200en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK

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