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Article: Patterns of somatic mutation in human cancer genomes

TitlePatterns of somatic mutation in human cancer genomes
Authors
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2007, v. 446 n. 7132, p. 153-158 How to Cite?
AbstractCancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations would lead to the discovery of many additional cancer genes. Here we report more than 1,000 somatic mutations found in 274 megabases (Mb) of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers. There was substantial variation in the number and pattern of mutations in individual cancers reflecting different exposures, DNA repair defects and cellular origins. Most somatic mutations are likely to be 'passengers' that do not contribute to oncogenesis. However, there was evidence for 'driver' mutations contributing to the development of the cancers studied in approximately 120 genes. Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated. ©2007 Nature Publishing Group.
Persistent Identifierhttp://hdl.handle.net/10722/88450
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGreenman, Cen_HK
dc.contributor.authorStephens, Pen_HK
dc.contributor.authorSmith, Ren_HK
dc.contributor.authorDalgliesh, GLen_HK
dc.contributor.authorHunter, Cen_HK
dc.contributor.authorBignell, Gen_HK
dc.contributor.authorDavies, Hen_HK
dc.contributor.authorTeague, Jen_HK
dc.contributor.authorButler, Aen_HK
dc.contributor.authorStevens, Cen_HK
dc.contributor.authorEdkins, Sen_HK
dc.contributor.authorO'Meara, Sen_HK
dc.contributor.authorVastrik, Ien_HK
dc.contributor.authorSchmidt, EEen_HK
dc.contributor.authorAvis, Ten_HK
dc.contributor.authorBarthorpe, Sen_HK
dc.contributor.authorBhamra, Gen_HK
dc.contributor.authorBuck, Gen_HK
dc.contributor.authorChoudhury, Ben_HK
dc.contributor.authorClements, Jen_HK
dc.contributor.authorCole, Jen_HK
dc.contributor.authorDicks, Een_HK
dc.contributor.authorForbes, Sen_HK
dc.contributor.authorGray, Ken_HK
dc.contributor.authorHalliday, Ken_HK
dc.contributor.authorHarrison, Ren_HK
dc.contributor.authorHills, Ken_HK
dc.contributor.authorHinton, Jen_HK
dc.contributor.authorJenkinson, Aen_HK
dc.contributor.authorJones, Den_HK
dc.contributor.authorMenzies, Aen_HK
dc.contributor.authorMironenko, Ten_HK
dc.contributor.authorPerry, Jen_HK
dc.contributor.authorRaine, Ken_HK
dc.contributor.authorRichardson, Den_HK
dc.contributor.authorShepherd, Ren_HK
dc.contributor.authorSmall, Aen_HK
dc.contributor.authorTofts, Cen_HK
dc.contributor.authorVarian, Jen_HK
dc.contributor.authorWebb, Ten_HK
dc.contributor.authorWest, Sen_HK
dc.contributor.authorWidaa, Sen_HK
dc.contributor.authorYates, Aen_HK
dc.contributor.authorCahill, DPen_HK
dc.contributor.authorLouis, DNen_HK
dc.contributor.authorGoldstraw, Pen_HK
dc.contributor.authorNicholson, AGen_HK
dc.contributor.authorBrasseur, Fen_HK
dc.contributor.authorLooijenga, Len_HK
dc.contributor.authorWeber, BLen_HK
dc.contributor.authorChiew, YEen_HK
dc.contributor.authorDeFazio, Aen_HK
dc.contributor.authorGreaves, MFen_HK
dc.contributor.authorGreen, ARen_HK
dc.contributor.authorCampbell, Pen_HK
dc.contributor.authorBirney, Een_HK
dc.contributor.authorEaston, DFen_HK
dc.contributor.authorChenevixTrench, Gen_HK
dc.contributor.authorTan, MHen_HK
dc.contributor.authorKhoo, SKen_HK
dc.contributor.authorTeh, BTen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorWooster, Ren_HK
dc.contributor.authorFutreal, PAen_HK
dc.contributor.authorStratton, MRen_HK
dc.date.accessioned2010-09-06T09:43:33Z-
dc.date.available2010-09-06T09:43:33Z-
dc.date.issued2007en_HK
dc.identifier.citationNature, 2007, v. 446 n. 7132, p. 153-158en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88450-
dc.description.abstractCancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for mutations would lead to the discovery of many additional cancer genes. Here we report more than 1,000 somatic mutations found in 274 megabases (Mb) of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers. There was substantial variation in the number and pattern of mutations in individual cancers reflecting different exposures, DNA repair defects and cellular origins. Most somatic mutations are likely to be 'passengers' that do not contribute to oncogenesis. However, there was evidence for 'driver' mutations contributing to the development of the cancers studied in approximately 120 genes. Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated. ©2007 Nature Publishing Group.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshDNA Mutational Analysisen_HK
dc.subject.meshGenes, Neoplasm - geneticsen_HK
dc.subject.meshGenome, Human - geneticsen_HK
dc.subject.meshGenomicsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshMutation - geneticsen_HK
dc.subject.meshNeoplasm Proteins - chemistry - geneticsen_HK
dc.subject.meshNeoplasms - geneticsen_HK
dc.subject.meshProtein Kinases - chemistry - geneticsen_HK
dc.titlePatterns of somatic mutation in human cancer genomesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-0836&volume=446 &issue=7132&spage=153&epage=8&date=2007&atitle=Patterns+of+somatic+mutation+in+human+cancer+genomesen_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nature05610en_HK
dc.identifier.pmid17344846-
dc.identifier.scopuseid_2-s2.0-33947101019en_HK
dc.identifier.hkuros126930en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947101019&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume446en_HK
dc.identifier.issue7132en_HK
dc.identifier.spage153en_HK
dc.identifier.epage158en_HK
dc.identifier.isiWOS:000244718100033-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.f10001068835-
dc.identifier.citeulike1146958-

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