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Article: Atypical Squamous Cells of Undetermined Significance on Cervical Smears: Follow-Up Study of an Asian Screening Population

TitleAtypical Squamous Cells of Undetermined Significance on Cervical Smears: Follow-Up Study of an Asian Screening Population
Authors
KeywordsAsian screening population
Atypical squamous cells of undetermined significance
Cervix
Cytology
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2004, v. 102 n. 2, p. 74-80 How to Cite?
AbstractBACKGROUND. The current study reports on the significance of cervical smears identified as atypical squamous cells of undetermined significance (ASCUS) in the largest Asian screening population to date. METHODS. From January 1998 to December 1999, 190,000 cervical smears were evaluated by the cervical cytology laboratory at the University of Hong Kong (Hong Kong, China). From these smears, 5579 ASCUS were identified. Follow-up cytology and histology findings were analyzed. RESULTS. Follow-up cytology or biopsy results were retrieved for 3601 women (64.5%). Of these, 544 (9.8%) and 96 women (1.7%) were found to have low-grade (LSIL) and high-grade (HSIL) squamous intraepithelial lesions, respectively. Biopsy results were obtained for 198 (36.4%) of the 544 women with LSIL. One hundred seventy-nine (32.9%) and 19 women (3.5%) were confirmed to have cervical intraepithelial neoplasia (CIN)-1 and CIN-2-CIN-3, respectively. Biopsy results were retrieved for 53 (55.2%) women with HSIL. Forty patients (41.7%) were confirmed to have CIN-2-CIN-3, whereas CIN-1 was found in the remaining patients. One woman with squamous cell carcinoma was diagnosed by colposcopic biopsy after immediate referral following a diagnosis of ASCUS. There was a significantly larger proportion of LSIL or HSIL (P < 0.0001) or higher-grade findings in women with ASCUS compared with the general screening population. Infective organisms were identified in 412 women (7.4%) with ASCUS. These women had a decreased risk of subsequent development of LSIL (P < 0.0001) or HSIL (P = 0.027). CONCLUSIONS: ASCUS smears indicated an increased risk of HSIL or carcinoma. The authors suggested careful patient follow-up in such cases. © 2004 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/88420
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorSzeto, EFen_HK
dc.contributor.authorNg, KMen_HK
dc.contributor.authorFong, KWen_HK
dc.contributor.authorYeung, ACEen_HK
dc.contributor.authorTsun, OKLen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorChan, KYKen_HK
dc.contributor.authorNg, AWYen_HK
dc.date.accessioned2010-09-06T09:43:08Z-
dc.date.available2010-09-06T09:43:08Z-
dc.date.issued2004en_HK
dc.identifier.citationCancer, 2004, v. 102 n. 2, p. 74-80en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/88420-
dc.description.abstractBACKGROUND. The current study reports on the significance of cervical smears identified as atypical squamous cells of undetermined significance (ASCUS) in the largest Asian screening population to date. METHODS. From January 1998 to December 1999, 190,000 cervical smears were evaluated by the cervical cytology laboratory at the University of Hong Kong (Hong Kong, China). From these smears, 5579 ASCUS were identified. Follow-up cytology and histology findings were analyzed. RESULTS. Follow-up cytology or biopsy results were retrieved for 3601 women (64.5%). Of these, 544 (9.8%) and 96 women (1.7%) were found to have low-grade (LSIL) and high-grade (HSIL) squamous intraepithelial lesions, respectively. Biopsy results were obtained for 198 (36.4%) of the 544 women with LSIL. One hundred seventy-nine (32.9%) and 19 women (3.5%) were confirmed to have cervical intraepithelial neoplasia (CIN)-1 and CIN-2-CIN-3, respectively. Biopsy results were retrieved for 53 (55.2%) women with HSIL. Forty patients (41.7%) were confirmed to have CIN-2-CIN-3, whereas CIN-1 was found in the remaining patients. One woman with squamous cell carcinoma was diagnosed by colposcopic biopsy after immediate referral following a diagnosis of ASCUS. There was a significantly larger proportion of LSIL or HSIL (P < 0.0001) or higher-grade findings in women with ASCUS compared with the general screening population. Infective organisms were identified in 412 women (7.4%) with ASCUS. These women had a decreased risk of subsequent development of LSIL (P < 0.0001) or HSIL (P = 0.027). CONCLUSIONS: ASCUS smears indicated an increased risk of HSIL or carcinoma. The authors suggested careful patient follow-up in such cases. © 2004 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAsian screening populationen_HK
dc.subjectAtypical squamous cells of undetermined significanceen_HK
dc.subjectCervixen_HK
dc.subjectCytologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshCervical Intraepithelial Neoplasia - diagnosisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMass Screeningen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRisken_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshUterine Cervical Neoplasms - diagnosisen_HK
dc.subject.meshVaginal Smearsen_HK
dc.titleAtypical Squamous Cells of Undetermined Significance on Cervical Smears: Follow-Up Study of an Asian Screening Populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=102&issue=2&spage=74&epage=80&date=2004&atitle=Atypical+squamous+cells+of+undetermined+significance+on+cervical+smears:+follow-up+study+of+an+Asian+screening+populationen_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.emailChan, KYK: kelvinc@pathology.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityChan, KYK=rp00453en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/cncr.20045en_HK
dc.identifier.pmid15098250-
dc.identifier.scopuseid_2-s2.0-1842831217en_HK
dc.identifier.hkuros86801en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842831217&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume102en_HK
dc.identifier.issue2en_HK
dc.identifier.spage74en_HK
dc.identifier.epage80en_HK
dc.identifier.isiWOS:000220908600002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridSzeto, EF=6603826287en_HK
dc.identifier.scopusauthoridNg, KM=7403178500en_HK
dc.identifier.scopusauthoridFong, KW=36870587700en_HK
dc.identifier.scopusauthoridYeung, ACE=7102390358en_HK
dc.identifier.scopusauthoridTsun, OKL=6505863560en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridChan, KYK=7406034195en_HK
dc.identifier.scopusauthoridNg, AWY=36850764000en_HK

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