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Article: Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: A prospective study

TitleTumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: A prospective study
Authors
Issue Date2002
PublisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/
Citation
Journal Of Clinical Oncology, 2002, v. 20 n. 7, p. 1775-1785 How to Cite?
AbstractPurpose: This study prospectively evaluated the correlation of tumor microvessel density (MVD) with clinicopathologic features and postoperative recurrence in patients undergoing resection of hepatocellular carcinoma (HCC). Patients and Methods: Tumor MVD was assessed in 100 patients with resection of HCC using a computer image analyzer after immunostaining for CD34 (MVD-CD34) and von Willebrand factor (MVD-vWF), respectively. Patients were prospectively followed for recurrence. Results: Mean tumor MVD-CD34 (236/0.74 mm 2) was higher than mean tumor MVD-vWF (87/0.74 mm 2) (P < .001). By multiple regression analysis, tumor size was the only pathologic feature significantly related to tumor MVD-CD34. The median MVD-CD34 was 316/0.74 mm 2 in HCCs ≤ 5 cm (n = 46) and 146/0.74 mm 2 in HCCs more than 5 cm (n = 54) (P < .001). Among patients with HCCs ≤ 5 cm, those with higher than median MVD-CD34 had worse disease-free survival (at 3 years, 13%) than those with a lower MVD-CD34 (at 3 year, 74%) (P = .002). Multivariate analysis showed that tumor MVD-CD34 was the only significant factor predictive of disease-free survival in patients with HCC ≤ 5 cm. For HCCs more than 5 cm, MVD-CD34 did not have a significant prognostic influence. MVD-vWF did not have a significant prognostic influence on disease-free survival in either HCCs ≤ 5 cm or more than 5 cm. Conclusion: This study shows that a high MVD-CD34 was predictive of early postresection recurrence in patients with HCCs ≤ 5 cm and, therefore, may be a novel prognostic marker in this subset of patients. © 2002 by American Society of Clinical Oncology.
Persistent Identifierhttp://hdl.handle.net/10722/88395
ISSN
2015 Impact Factor: 20.982
2015 SCImago Journal Rankings: 9.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorLau, Cen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorYang, ZFen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T09:42:48Z-
dc.date.available2010-09-06T09:42:48Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Clinical Oncology, 2002, v. 20 n. 7, p. 1775-1785en_HK
dc.identifier.issn0732-183Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/88395-
dc.description.abstractPurpose: This study prospectively evaluated the correlation of tumor microvessel density (MVD) with clinicopathologic features and postoperative recurrence in patients undergoing resection of hepatocellular carcinoma (HCC). Patients and Methods: Tumor MVD was assessed in 100 patients with resection of HCC using a computer image analyzer after immunostaining for CD34 (MVD-CD34) and von Willebrand factor (MVD-vWF), respectively. Patients were prospectively followed for recurrence. Results: Mean tumor MVD-CD34 (236/0.74 mm 2) was higher than mean tumor MVD-vWF (87/0.74 mm 2) (P < .001). By multiple regression analysis, tumor size was the only pathologic feature significantly related to tumor MVD-CD34. The median MVD-CD34 was 316/0.74 mm 2 in HCCs ≤ 5 cm (n = 46) and 146/0.74 mm 2 in HCCs more than 5 cm (n = 54) (P < .001). Among patients with HCCs ≤ 5 cm, those with higher than median MVD-CD34 had worse disease-free survival (at 3 years, 13%) than those with a lower MVD-CD34 (at 3 year, 74%) (P = .002). Multivariate analysis showed that tumor MVD-CD34 was the only significant factor predictive of disease-free survival in patients with HCC ≤ 5 cm. For HCCs more than 5 cm, MVD-CD34 did not have a significant prognostic influence. MVD-vWF did not have a significant prognostic influence on disease-free survival in either HCCs ≤ 5 cm or more than 5 cm. Conclusion: This study shows that a high MVD-CD34 was predictive of early postresection recurrence in patients with HCCs ≤ 5 cm and, therefore, may be a novel prognostic marker in this subset of patients. © 2002 by American Society of Clinical Oncology.en_HK
dc.languageengen_HK
dc.publisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/en_HK
dc.relation.ispartofJournal of Clinical Oncologyen_HK
dc.subject.meshAntigens, CD34 - analysisen_HK
dc.subject.meshCarcinoma, Hepatocellular - blood supply - immunologyen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Interpretation, Computer-Assisteden_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLiver Neoplasms - blood supply - immunologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrocirculationen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshNeoplasm Recurrence, Local - blood supplyen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshTumor Markers, Biological - analysisen_HK
dc.titleTumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: A prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0732-183X&volume=20&spage=1775&epage=1785&date=2002&atitle=Tumor+microvessel+density+as+a+predictor+of+recurrence+after+resection+of+hepatocellular+carcinoma:+a+prospective+studyen_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1200/JCO.2002.07.089en_HK
dc.identifier.pmid11919234-
dc.identifier.scopuseid_2-s2.0-0036534375en_HK
dc.identifier.hkuros68698en_HK
dc.identifier.hkuros79653-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036534375&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1775en_HK
dc.identifier.epage1785en_HK
dc.identifier.isiWOS:000174845200012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridLau, C=8086563300en_HK
dc.identifier.scopusauthoridYu, WC=24490445800en_HK
dc.identifier.scopusauthoridYang, ZF=14018809600en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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