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Article: Better survival in women with resected hepatocellular carcinoma is not related to tumor proliferation or expression of hormone receptors

TitleBetter survival in women with resected hepatocellular carcinoma is not related to tumor proliferation or expression of hormone receptors
Authors
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 1997, v. 92 n. 8, p. 1355-1358 How to Cite?
AbstractObjective: There is a well known male predominance in hepatocellular carcinoma (HCC). Moreover, female patients with HCC have better survival and lower recurrence rates after surgical resection. We previously showed that the better prognosis in female patients is related to a higher incidence of tumor encapsulation and less invasive tumors. However, the underlying mechanism is still obscure. Methods: In this study, we examined the cell proliferative indices (expression of proliferative cell nuclear antigen (PCNA) and Ki-67 antigen using MIB1 antibody) and expression of the estrogen and progesterone receptors (ERs and PRs, respectively)in 71 patients with resected HCC. These were correlated with the pathological features of the tumors and the survival rates of patients. Results: Female patients with HCC had significantly better actuarial and disease-free survival rates than male patients (p = 0.010 and 0.004, respectively). Tumor PCNA scores, represented by positively stained nuclei per 1000 tumor cells, were significantly higher in tumors showing venous permeation (p = 0.034), positive resection margins (p = 0.011), and absence of bile production (p = 0.008). Higher tumor MIB1 scores were seen in tumors that had poorer cellular differentiation (p = 0.002) and no tumor capsules (p = 0.042). However, both tumor PCNA and MIB1 scores did not differ significantly between female and male patients. ERs were detected in the tumor cells in 23.9% of tumors, and PRS were detected in 14.3%. Expression of both ER and PR was not influenced by gender. Conclusions: Women with HCC had significantly better survival and lower tumor recurrence rates. However, significant differences in cellular proliferation indices and expression of ER and PR were not observed between men and women to explain the difference in survival rate.
Persistent Identifierhttp://hdl.handle.net/10722/88394
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-09-06T09:42:48Z-
dc.date.available2010-09-06T09:42:48Z-
dc.date.issued1997en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 1997, v. 92 n. 8, p. 1355-1358en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88394-
dc.description.abstractObjective: There is a well known male predominance in hepatocellular carcinoma (HCC). Moreover, female patients with HCC have better survival and lower recurrence rates after surgical resection. We previously showed that the better prognosis in female patients is related to a higher incidence of tumor encapsulation and less invasive tumors. However, the underlying mechanism is still obscure. Methods: In this study, we examined the cell proliferative indices (expression of proliferative cell nuclear antigen (PCNA) and Ki-67 antigen using MIB1 antibody) and expression of the estrogen and progesterone receptors (ERs and PRs, respectively)in 71 patients with resected HCC. These were correlated with the pathological features of the tumors and the survival rates of patients. Results: Female patients with HCC had significantly better actuarial and disease-free survival rates than male patients (p = 0.010 and 0.004, respectively). Tumor PCNA scores, represented by positively stained nuclei per 1000 tumor cells, were significantly higher in tumors showing venous permeation (p = 0.034), positive resection margins (p = 0.011), and absence of bile production (p = 0.008). Higher tumor MIB1 scores were seen in tumors that had poorer cellular differentiation (p = 0.002) and no tumor capsules (p = 0.042). However, both tumor PCNA and MIB1 scores did not differ significantly between female and male patients. ERs were detected in the tumor cells in 23.9% of tumors, and PRS were detected in 14.3%. Expression of both ER and PR was not influenced by gender. Conclusions: Women with HCC had significantly better survival and lower tumor recurrence rates. However, significant differences in cellular proliferation indices and expression of ER and PR were not observed between men and women to explain the difference in survival rate.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshCarcinoma, Hepatocellular - metabolism - mortality - pathology - surgeryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKi-67 Antigen - biosynthesisen_HK
dc.subject.meshLiver - metabolismen_HK
dc.subject.meshLiver Neoplasms - metabolism - mortality - pathology - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshProliferating Cell Nuclear Antigen - biosynthesisen_HK
dc.subject.meshReceptors, Estrogen - biosynthesisen_HK
dc.subject.meshReceptors, Progesterone - biosynthesisen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleBetter survival in women with resected hepatocellular carcinoma is not related to tumor proliferation or expression of hormone receptorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9270&volume=92&spage=1355&epage=1358&date=1997&atitle=Better+survival+in+women+with+resected+hepatocellular+carcinoma+is+not+related+to+tumor+proliferation+or+expression+of+hormone+receptorsen_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9260806-
dc.identifier.scopuseid_2-s2.0-0030854691en_HK
dc.identifier.hkuros34060en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030854691&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1355en_HK
dc.identifier.epage1358en_HK
dc.identifier.isiWOS:A1997XP75600025-
dc.publisher.placeUnited Statesen_HK

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