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Article: An Epstein-Barr virus positive undifferentiated carcinoma in the lacrimal sac

TitleAn Epstein-Barr virus positive undifferentiated carcinoma in the lacrimal sac
Authors
KeywordsEpstein-Barr virus
Lacrimal sac
Lymphoepithelioma
Undifferentiated carcinoma
Issue Date1996
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 1996, v. 28 n. 1, p. 71-75 How to Cite?
AbstractWe report a Chinese patient who presented with metastatic undifferentiated carcinoma in the cervical lymph node of unknown primary origin. Despite a raised IgA titre against Epstein-Barr virus capsid antigen, examination and biopsy of the nasopharynx were negative. Radiotherapy was given to the head and neck region with the orbit shielded. There was complete resolution of the metastatic lymph nodes. She developed proptosis of her left eye one year afterward when a large tumour was found in the lacrimal sac region. Review of the initial computerized tomography revealed a small soft tissue mass in the same region. The tumour was composed of undifferentiated carcinoma cells associated with dense lymphoid infiltrate. In situ hybridization for Epstein-Barr virus EBER RNA showed strong positive signals in the malignant cells. This is the first reported case of an Epstein-Barr virus positive undifferentiated carcinoma with lymphoid stroma in the lacrimal sac. In addition to the nasopharynx, salivary glands, nasal cavity and paranasal sinuses, the lacrimal sac should be considered as a potential primary site for Epstein-Barr virus positive metastatic undifferentiated carcinoma in the cervical lymph nodes.
Persistent Identifierhttp://hdl.handle.net/10722/88386
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorHo, CMen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorKwong, WKen_HK
dc.date.accessioned2010-09-06T09:42:41Z-
dc.date.available2010-09-06T09:42:41Z-
dc.date.issued1996en_HK
dc.identifier.citationHistopathology, 1996, v. 28 n. 1, p. 71-75en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88386-
dc.description.abstractWe report a Chinese patient who presented with metastatic undifferentiated carcinoma in the cervical lymph node of unknown primary origin. Despite a raised IgA titre against Epstein-Barr virus capsid antigen, examination and biopsy of the nasopharynx were negative. Radiotherapy was given to the head and neck region with the orbit shielded. There was complete resolution of the metastatic lymph nodes. She developed proptosis of her left eye one year afterward when a large tumour was found in the lacrimal sac region. Review of the initial computerized tomography revealed a small soft tissue mass in the same region. The tumour was composed of undifferentiated carcinoma cells associated with dense lymphoid infiltrate. In situ hybridization for Epstein-Barr virus EBER RNA showed strong positive signals in the malignant cells. This is the first reported case of an Epstein-Barr virus positive undifferentiated carcinoma with lymphoid stroma in the lacrimal sac. In addition to the nasopharynx, salivary glands, nasal cavity and paranasal sinuses, the lacrimal sac should be considered as a potential primary site for Epstein-Barr virus positive metastatic undifferentiated carcinoma in the cervical lymph nodes.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.rightsHistopathology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectEpstein-Barr virusen_HK
dc.subjectLacrimal sacen_HK
dc.subjectLymphoepitheliomaen_HK
dc.subjectUndifferentiated carcinomaen_HK
dc.subject.meshAdulten_HK
dc.subject.meshCarcinoma - pathology - virologyen_HK
dc.subject.meshEye Neoplasms - pathology - virologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHerpesviridae Infectionsen_HK
dc.subject.meshHerpesvirus 4, Human - genetics - isolation & purification - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshLacrimal Apparatus - pathologyen_HK
dc.subject.meshLacrimal Apparatus Diseases - pathologyen_HK
dc.subject.meshLymphatic Metastasisen_HK
dc.subject.meshRNA, Viral - metabolismen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshTumor Virus Infectionsen_HK
dc.titleAn Epstein-Barr virus positive undifferentiated carcinoma in the lacrimal sacen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0309-0167&volume=28&spage=71&epage=75&date=1996&atitle=An+Epstein-Barr+virus+positive+undifferentiated+carcinoma+in+the+lacrimal+sacen_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2559.1996.264307.x-
dc.identifier.pmid8838124-
dc.identifier.scopuseid_2-s2.0-0030050919en_HK
dc.identifier.hkuros9743en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030050919&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue1en_HK
dc.identifier.spage71en_HK
dc.identifier.epage75en_HK
dc.identifier.isiWOS:A1996TQ72300010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridHo, CM=7404652540en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridKwong, WK=7005955797en_HK

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