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Article: Follicular Dendritic Cell Tumor of the Liver: Evidence for an Epstein-Barr Virus-related Clonal Proliferation of Follicular Dendritic Cells

TitleFollicular Dendritic Cell Tumor of the Liver: Evidence for an Epstein-Barr Virus-related Clonal Proliferation of Follicular Dendritic Cells
Authors
Issue Date1996
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 1996, v. 20 n. 3, p. 313-324 How to Cite?
AbstractTumors of the follicular dendritic cell are uncommon, and most occur as primary lymph node tumors. We report a case of primary follicular dendritic cell tumor of the liver that was initially reported as an inflammatory pseudotumor. The neoplasm recurred as two separate tumor masses 30 months after complete resection of the hepatic inflammatory pseudotumor. It showed a wide spectrum of morphologic features ranging from areas with fascicles of very bland spindle cells amidst a background population of lymphocytes, reminiscent of inflammatory pseudotumor, to areas of dispersed sheets of highly pleomorphic tumor cells with a relative paucity of reactive inflammatory cells. The diagnosis was confirmed by positive immunohistochemical staining with CD21, CD35, R4/23, and Ki-M4 and by ultrastructural demonstration of convoluted interdigitating cell processes joined by desmosomes. The background lymphocytes were oligoclonal, CD8-positive T cells. In situ hybridization for Epstein-Barr virus (EBV)-encoded RNA was positive in the tumor cells in the original and recurrent tumors. More importantly, the cells showed identical episomal clonal EBV on Southern blot analysis, implying that the initial and recurrent tumors are due to clonal proliferation of EBV-positive neoplastic follicular dendritic cells. The tumor cells expressed latent membrane protein but not EBV-encoded nuclear antigen 2 (EBNA2) or ZEBRA. Such gene expression is very similar to that of Hodgkin's disease and nasopharyngeal carcinoma. The strong expression of latent membrane protein restricted to the tumor cells and the clonality of the EBV suggest that the virus may be involved in the pathogenesis of this tumor and not present merely as a bystander..
Persistent Identifierhttp://hdl.handle.net/10722/88361
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorHo, FCSen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorSrivastava, Gen_HK
dc.date.accessioned2010-09-06T09:42:22Z-
dc.date.available2010-09-06T09:42:22Z-
dc.date.issued1996en_HK
dc.identifier.citationAmerican Journal Of Surgical Pathology, 1996, v. 20 n. 3, p. 313-324en_HK
dc.identifier.issn0147-5185en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88361-
dc.description.abstractTumors of the follicular dendritic cell are uncommon, and most occur as primary lymph node tumors. We report a case of primary follicular dendritic cell tumor of the liver that was initially reported as an inflammatory pseudotumor. The neoplasm recurred as two separate tumor masses 30 months after complete resection of the hepatic inflammatory pseudotumor. It showed a wide spectrum of morphologic features ranging from areas with fascicles of very bland spindle cells amidst a background population of lymphocytes, reminiscent of inflammatory pseudotumor, to areas of dispersed sheets of highly pleomorphic tumor cells with a relative paucity of reactive inflammatory cells. The diagnosis was confirmed by positive immunohistochemical staining with CD21, CD35, R4/23, and Ki-M4 and by ultrastructural demonstration of convoluted interdigitating cell processes joined by desmosomes. The background lymphocytes were oligoclonal, CD8-positive T cells. In situ hybridization for Epstein-Barr virus (EBV)-encoded RNA was positive in the tumor cells in the original and recurrent tumors. More importantly, the cells showed identical episomal clonal EBV on Southern blot analysis, implying that the initial and recurrent tumors are due to clonal proliferation of EBV-positive neoplastic follicular dendritic cells. The tumor cells expressed latent membrane protein but not EBV-encoded nuclear antigen 2 (EBNA2) or ZEBRA. Such gene expression is very similar to that of Hodgkin's disease and nasopharyngeal carcinoma. The strong expression of latent membrane protein restricted to the tumor cells and the clonality of the EBV suggest that the virus may be involved in the pathogenesis of this tumor and not present merely as a bystander..en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_HK
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_HK
dc.rightsAmerican Journal of Surgical Pathology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshCell Division - physiologyen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshDendritic Cells - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshGene Rearrangementen_HK
dc.subject.meshHerpesvirus 4, Human - genetics - isolation & purification - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLiver Neoplasms - metabolism - pathology - virologyen_HK
dc.subject.meshReceptors, Antigen, T-Cell - geneticsen_HK
dc.titleFollicular Dendritic Cell Tumor of the Liver: Evidence for an Epstein-Barr Virus-related Clonal Proliferation of Follicular Dendritic Cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0147-5185&volume=20&issue=3&spage=313&epage=324&date=1996&atitle=Follicular+dendritic+cell+tumor+of+the+liver:+evidence+for+an+Epstein-Barr+virus-related+clonal+proliferation+of+follicular+dendritic+cellsen_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8772785-
dc.identifier.scopuseid_2-s2.0-0030029985en_HK
dc.identifier.hkuros14061en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030029985&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue3en_HK
dc.identifier.spage313en_HK
dc.identifier.epage324en_HK
dc.identifier.isiWOS:A1996TX84300008-
dc.publisher.placeUnited Statesen_HK

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