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Article: A modified method of auxiliary partial liver transplantation in the rat

TitleA modified method of auxiliary partial liver transplantation in the rat
Authors
KeywordsAuxiliary liver transplantation
Rat
Issue Date1999
PublisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html
Citation
Hepato-Gastroenterology, 1999, v. 46 n. 25, p. 428-431 How to Cite?
AbstractBACKGROUND/AIMS: In the animal model of auxiliary partial liver transplantation in the rat, the major problem is high outflow pressure since the direction of vascular outflow of the graft was perpendicular to that of the recipient inferior vena cava (IVC) and the anastomosis was far away from the right atrium. We aimed at developing an animal model that could prevent graft congestion. METHODOLOGY: The graft contained the right lateral lobe and triangulated lobe of rat's liver. The modification of implantation included anatomizing an oblique cuff of IVC of donor graft into the recipient's IVC so that the size of anastomosis was large with an angle of 45°and the resulting vascular outflow was no longer perpendicular to that of the recipient's IVC, and the creation of double grooves on the cuff body of the donor portal vein. Bile drainage was completed by inserting the bile duct (together with a stent) into the recipient's duodenum. RESULTS: Congestion of grafts was not seen in 25 rats undergoing auxiliary partial liver transplantation using an oblique IVC graft. The 1-week and 2-week survival rates were 88% and 80%, respectively. In the group of rats (n = 10) operated on by using a straight IVC graft, graft congestion was seen and only 1 rat could survive over 1 day. CONCLUSIONS: Modification of vascular outflow anastomosis prevented graft congestion and improved animal survival. The model may be useful for studying liver regeneration, transplantation immunology, and gene transfer.
Persistent Identifierhttp://hdl.handle.net/10722/88314
ISSN
2015 Impact Factor: 0.792
2015 SCImago Journal Rankings: 0.446
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, YNen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorTo, Jen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-06T09:41:45Z-
dc.date.available2010-09-06T09:41:45Z-
dc.date.issued1999en_HK
dc.identifier.citationHepato-Gastroenterology, 1999, v. 46 n. 25, p. 428-431en_HK
dc.identifier.issn0172-6390en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88314-
dc.description.abstractBACKGROUND/AIMS: In the animal model of auxiliary partial liver transplantation in the rat, the major problem is high outflow pressure since the direction of vascular outflow of the graft was perpendicular to that of the recipient inferior vena cava (IVC) and the anastomosis was far away from the right atrium. We aimed at developing an animal model that could prevent graft congestion. METHODOLOGY: The graft contained the right lateral lobe and triangulated lobe of rat's liver. The modification of implantation included anatomizing an oblique cuff of IVC of donor graft into the recipient's IVC so that the size of anastomosis was large with an angle of 45°and the resulting vascular outflow was no longer perpendicular to that of the recipient's IVC, and the creation of double grooves on the cuff body of the donor portal vein. Bile drainage was completed by inserting the bile duct (together with a stent) into the recipient's duodenum. RESULTS: Congestion of grafts was not seen in 25 rats undergoing auxiliary partial liver transplantation using an oblique IVC graft. The 1-week and 2-week survival rates were 88% and 80%, respectively. In the group of rats (n = 10) operated on by using a straight IVC graft, graft congestion was seen and only 1 rat could survive over 1 day. CONCLUSIONS: Modification of vascular outflow anastomosis prevented graft congestion and improved animal survival. The model may be useful for studying liver regeneration, transplantation immunology, and gene transfer.en_HK
dc.languageengen_HK
dc.publisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.htmlen_HK
dc.relation.ispartofHepato-Gastroenterologyen_HK
dc.subjectAuxiliary liver transplantationen_HK
dc.subjectRaten_HK
dc.subject.meshAnastomosis, Surgical - methodsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshFeasibility Studiesen_HK
dc.subject.meshGraft Occlusion, Vascular - prevention & controlen_HK
dc.subject.meshLiver Transplantation - methodsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleA modified method of auxiliary partial liver transplantation in the raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0172-6390&volume=46&spage=428&epage=431&date=1999&atitle=A+modified+method+of+auxiliary+partial+liver+transplantation+in+the+raten_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10228835-
dc.identifier.scopuseid_2-s2.0-0033063737en_HK
dc.identifier.hkuros41285en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033063737&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue25en_HK
dc.identifier.spage428en_HK
dc.identifier.epage431en_HK
dc.identifier.isiWOS:000079268000080-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridWang, YN=7601490264en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridTo, J=6603618643en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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