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Article: Expression of vascular endothelial growth factor in von Hippel-Lindau syndrome-associated papillary cystadenoma of the epididymis

TitleExpression of vascular endothelial growth factor in von Hippel-Lindau syndrome-associated papillary cystadenoma of the epididymis
Authors
KeywordsEpididymal cystadenoma
Hemangioblastoma
Vascular endothelial growth factor
Von Hippel-Lindau syndrome
Issue Date1998
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1998, v. 29 n. 11, p. 1322-1324 How to Cite?
AbstractVascular endothelial growth factor (VEGF) is a hypoxia inducible angiogenic and vascular permeability factor. Although VEGF expression in glioblastoma is induced by hypoxia, its expression in renal cell carcinoma and hemangioblastoma is thought to be related to mutation of the yon Hippel- Lindau (VHL) gene. It is not certain whether other lesions in VHL syndrome are associated with an elevated VEGF level. We report a VHL syndrome patient with multiple hemangioblastomas and bilateral epididymal clear cell papillary cystadenomas. In situ hybridization revealed high levels of VEGF mRNA in the clear cells of the epididymal tumor and the stromal cells of the hemangioblastoma. This lends support to the notion that upregulation of VEGF is caused by loss of the wild-type VHL protein. We postulate that the elevated VEGF levels may account for the cyst formation and vascularized stroma present in these VHL-associated tumors.
Persistent Identifierhttp://hdl.handle.net/10722/88295
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorChan, ASYen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorFan, YWen_HK
dc.contributor.authorChung, LPen_HK
dc.date.accessioned2010-09-06T09:41:30Z-
dc.date.available2010-09-06T09:41:30Z-
dc.date.issued1998en_HK
dc.identifier.citationHuman Pathology, 1998, v. 29 n. 11, p. 1322-1324en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88295-
dc.description.abstractVascular endothelial growth factor (VEGF) is a hypoxia inducible angiogenic and vascular permeability factor. Although VEGF expression in glioblastoma is induced by hypoxia, its expression in renal cell carcinoma and hemangioblastoma is thought to be related to mutation of the yon Hippel- Lindau (VHL) gene. It is not certain whether other lesions in VHL syndrome are associated with an elevated VEGF level. We report a VHL syndrome patient with multiple hemangioblastomas and bilateral epididymal clear cell papillary cystadenomas. In situ hybridization revealed high levels of VEGF mRNA in the clear cells of the epididymal tumor and the stromal cells of the hemangioblastoma. This lends support to the notion that upregulation of VEGF is caused by loss of the wild-type VHL protein. We postulate that the elevated VEGF levels may account for the cyst formation and vascularized stroma present in these VHL-associated tumors.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectEpididymal cystadenomaen_HK
dc.subjectHemangioblastomaen_HK
dc.subjectVascular endothelial growth factoren_HK
dc.subjectVon Hippel-Lindau syndromeen_HK
dc.subject.meshAdulten_HK
dc.subject.meshCystadenoma, Papillary - complications - metabolism - pathologyen_HK
dc.subject.meshEndothelial Growth Factors - biosynthesisen_HK
dc.subject.meshEpididymis - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshLymphokines - biosynthesisen_HK
dc.subject.meshMaleen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshTesticular Neoplasms - complications - metabolism - pathologyen_HK
dc.subject.meshVascular Endothelial Growth Factor Aen_HK
dc.subject.meshVascular Endothelial Growth Factorsen_HK
dc.subject.meshvon Hippel-Lindau Disease - complications - metabolism - pathologyen_HK
dc.titleExpression of vascular endothelial growth factor in von Hippel-Lindau syndrome-associated papillary cystadenoma of the epididymisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=29&issue=11&spage=1322&epage=1324&date=1998&atitle=Expression+of+vascular+endothelial+growth+factor+in+Von+Hippel-Lindau+syndrome-associated+papillary+cystadenoma+of+the+epididymisen_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9824115-
dc.identifier.scopuseid_2-s2.0-13144279346en_HK
dc.identifier.hkuros40699en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13144279346&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1322en_HK
dc.identifier.epage1324en_HK
dc.identifier.isiWOS:000076903000024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridChan, ASY=55246984000en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridFan, YW=7403492523en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK

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