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Article: Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo study

TitleStrontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo study
Authors
KeywordsBioactive bone cement
Bone remodeling
Strontium-containing hydroxyapatite
Total hip arthroplasty
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2006, v. 77 n. 2, p. 409-415 How to Cite?
AbstractThe purpose of this study was to evaluate the strontium-containing hydroxyapatite (Sr-HA) cement in primary hip replacement, using a rabbit model, and to investigate the histological findings at the cement-implant and bone-cement interfaces under weight-bearing conditions. Unilateral hip replacement was performed with Sr-HA cement or polymethylmethacrylate (PMMA) cement in rabbits and observations were made after 6 months. Good fixation between the Sr-HA cement and implant was observed. Osseointegration of the Sr-HA cement with cancellous bone was widespread. Many multinucleus cells covered the surface of the cement, and resorbed the superficial layer of the cement. By scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, high calcium and phosphorus levels were detected at the interface with a thickness of about 10 μm. Intimate contact was also observed between the Sr-HA cement and cortical bone without fibrous layer intervening. The overall affinity index of bone on Sr-HA cement was (85.06 ± 5.40)%, which is significantly higher than that on PMMA cement (2.77 %± 0.49%). On the contrary, a fibrous layer was consistently observed between PMMA cement and bone, and PMMA cement evoked an inflammatory response and foreign body reaction in the surrounding bony tissues. Results suggested good bioactivity and bone-bonding ability of the Sr-HA cement under weight-bearing conditions. © 2005 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/87584
ISSN
2004 Impact Factor: 3.652
2006 SCImago Journal Rankings: 0.474
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNi, GXen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorChiu, KYen_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-09-06T09:31:44Z-
dc.date.available2010-09-06T09:31:44Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2006, v. 77 n. 2, p. 409-415en_HK
dc.identifier.issn0021-9304en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87584-
dc.description.abstractThe purpose of this study was to evaluate the strontium-containing hydroxyapatite (Sr-HA) cement in primary hip replacement, using a rabbit model, and to investigate the histological findings at the cement-implant and bone-cement interfaces under weight-bearing conditions. Unilateral hip replacement was performed with Sr-HA cement or polymethylmethacrylate (PMMA) cement in rabbits and observations were made after 6 months. Good fixation between the Sr-HA cement and implant was observed. Osseointegration of the Sr-HA cement with cancellous bone was widespread. Many multinucleus cells covered the surface of the cement, and resorbed the superficial layer of the cement. By scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, high calcium and phosphorus levels were detected at the interface with a thickness of about 10 μm. Intimate contact was also observed between the Sr-HA cement and cortical bone without fibrous layer intervening. The overall affinity index of bone on Sr-HA cement was (85.06 ± 5.40)%, which is significantly higher than that on PMMA cement (2.77 %± 0.49%). On the contrary, a fibrous layer was consistently observed between PMMA cement and bone, and PMMA cement evoked an inflammatory response and foreign body reaction in the surrounding bony tissues. Results suggested good bioactivity and bone-bonding ability of the Sr-HA cement under weight-bearing conditions. © 2005 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/en_HK
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterialsen_HK
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectBioactive bone cementen_HK
dc.subjectBone remodelingen_HK
dc.subjectStrontium-containing hydroxyapatiteen_HK
dc.subjectTotal hip arthroplastyen_HK
dc.subject.meshBiodegradation, Environmental-
dc.subject.meshBone Cements - adverse effects - chemistry-
dc.subject.meshHip Prosthesis-
dc.subject.meshMaterials Testing-
dc.subject.meshStrontium-
dc.titleStrontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.emailChiu, KY: pkychiu@hkucc.hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.b.30417en_HK
dc.identifier.pmid16278857en_HK
dc.identifier.scopuseid_2-s2.0-33646352760en_HK
dc.identifier.hkuros115647en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646352760&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue2en_HK
dc.identifier.spage409en_HK
dc.identifier.epage415en_HK
dc.identifier.isiWOS:000237101000024-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridNi, GX=8303037400en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.scopusauthoridLi, ZY=35784563200en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK

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