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Article: Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer

TitleHomozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer
Authors
KeywordsCervical cancer
HPV
p53 Arg-72
Prognosis
Issue Date2000
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBI
Citation
Tumor Biology, 2000, v. 21 n. 3, p. 135-138 How to Cite?
AbstractMutation of p53, a tumour suppressor gene, is uncommon in cervical cancer but the detection of human papillomavirus (HPV) DNA in cervical cancer is common. The findings of increased susceptibility to degradation of p53 by E6 protein of HPV16/18 in cervical cancer with homozygous arginine at codon 72 (HA72) of p53 led to this study on whether cervical cancers with HA72 were more aggressive with the increase in the rate of loss of p53 function. In 102 cervical cancers, 76.5% were HPV16/18 positive and 30% had HA72. No survival difference was detected between HA72 and non-HA72 tumours irrespective of HPV16/18 status. Furthermore, the detection of HPV16/18 in cervical cancer was found not to be of prognostic significance in this study. (C) 2000 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/87495
ISSN
2015 Impact Factor: 2.926
2015 SCImago Journal Rankings: 0.989
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorLiu, SSen_HK
dc.contributor.authorCheng, DKLen_HK
dc.contributor.authorNg, TYen_HK
dc.contributor.authorWong, LCen_HK
dc.date.accessioned2010-09-06T09:30:24Z-
dc.date.available2010-09-06T09:30:24Z-
dc.date.issued2000en_HK
dc.identifier.citationTumor Biology, 2000, v. 21 n. 3, p. 135-138en_HK
dc.identifier.issn1010-4283en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87495-
dc.description.abstractMutation of p53, a tumour suppressor gene, is uncommon in cervical cancer but the detection of human papillomavirus (HPV) DNA in cervical cancer is common. The findings of increased susceptibility to degradation of p53 by E6 protein of HPV16/18 in cervical cancer with homozygous arginine at codon 72 (HA72) of p53 led to this study on whether cervical cancers with HA72 were more aggressive with the increase in the rate of loss of p53 function. In 102 cervical cancers, 76.5% were HPV16/18 positive and 30% had HA72. No survival difference was detected between HA72 and non-HA72 tumours irrespective of HPV16/18 status. Furthermore, the detection of HPV16/18 in cervical cancer was found not to be of prognostic significance in this study. (C) 2000 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBIen_HK
dc.relation.ispartofTumor Biologyen_HK
dc.subjectCervical canceren_HK
dc.subjectHPVen_HK
dc.subjectp53 Arg-72en_HK
dc.subjectPrognosisen_HK
dc.titleHomozygous arginine at codon 72 of p53 has no prognostic significance in cervical canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1010-4283&volume=21&spage=135&epage=138&date=2000&atitle=Homozygous+arginine+at+codon+72+of+p53+has+no+prognostic+significance+in+cervical+canceren_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailLiu, SS: stephasl@hku.hken_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityLiu, SS=rp00372en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10754463en_HK
dc.identifier.scopuseid_2-s2.0-0034108193en_HK
dc.identifier.hkuros49570en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034108193&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue3en_HK
dc.identifier.spage135en_HK
dc.identifier.epage138en_HK
dc.identifier.isiWOS:000086713200002-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridLiu, SS=37102450400en_HK
dc.identifier.scopusauthoridCheng, DKL=7402806161en_HK
dc.identifier.scopusauthoridNg, TY=7402229853en_HK
dc.identifier.scopusauthoridWong, LC=7402092003en_HK

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