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Article: Abnormal expression of pan-ras, c-myc and tp53 in squamous cell carcinoma of cervix: Correlation with HPV and prognosis

TitleAbnormal expression of pan-ras, c-myc and tp53 in squamous cell carcinoma of cervix: Correlation with HPV and prognosis
Authors
KeywordsC-myc
HPV
Immunohistochemical staining
Pan-ras
Prognosis
Tp53
Issue Date2001
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 2001, v. 8 n. 3, p. 557-561 How to Cite?
AbstractThe aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A and 53 were of stage 2B and above. Positive IHC stainings of pan-ras, c-myc and tp53 proteins were detected in 80.4%, 32.7% and 25.2% of cases, respectively. No significant correlation between over-expression of pan-ras and c-myc was detected. However, significantly higher percentages of overexpression of c-myc was found in association with overly expressed tp53 samples (p=0.014). Human papillomavirus (HPV) was detected in 77.6% of cancers. HPV 16/18 was detected in 72% of cancers. Overexpression of pan-ras and c-myc had no correlation with HPV detection and stage. However, higher percentages of overexpression of tp53 were found in early stage disease (p=0.017) and in HPV 16/18 positive tumors (p=0.006). Overexpression of pan-ras, c-myc and tp53 alone or in more than one oncogenes had no prognostic significance on survival.
Persistent Identifierhttp://hdl.handle.net/10722/87492
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:30:21Z-
dc.date.available2010-09-06T09:30:21Z-
dc.date.issued2001en_HK
dc.identifier.citationOncology Reports, 2001, v. 8 n. 3, p. 557-561en_HK
dc.identifier.issn1021-335Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/87492-
dc.description.abstractThe aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A and 53 were of stage 2B and above. Positive IHC stainings of pan-ras, c-myc and tp53 proteins were detected in 80.4%, 32.7% and 25.2% of cases, respectively. No significant correlation between over-expression of pan-ras and c-myc was detected. However, significantly higher percentages of overexpression of c-myc was found in association with overly expressed tp53 samples (p=0.014). Human papillomavirus (HPV) was detected in 77.6% of cancers. HPV 16/18 was detected in 72% of cancers. Overexpression of pan-ras and c-myc had no correlation with HPV detection and stage. However, higher percentages of overexpression of tp53 were found in early stage disease (p=0.017) and in HPV 16/18 positive tumors (p=0.006). Overexpression of pan-ras, c-myc and tp53 alone or in more than one oncogenes had no prognostic significance on survival.en_HK
dc.languageengen_HK
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_HK
dc.relation.ispartofOncology Reportsen_HK
dc.subjectC-mycen_HK
dc.subjectHPVen_HK
dc.subjectImmunohistochemical stainingen_HK
dc.subjectPan-rasen_HK
dc.subjectPrognosisen_HK
dc.subjectTp53en_HK
dc.titleAbnormal expression of pan-ras, c-myc and tp53 in squamous cell carcinoma of cervix: Correlation with HPV and prognosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1021-335X&volume=8&spage=557&epage=561&date=2001&atitle=Abnormal+expression+of+pan-ras,+c-myc+and+tp53+in+squamous+cell+carcinomas+of+cervix:+correlation+with+HPV+and+prognosisen_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3892/or.8.3.557-
dc.identifier.pmid11295080en_HK
dc.identifier.scopuseid_2-s2.0-0035349958en_HK
dc.identifier.hkuros56629en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035349958&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue3en_HK
dc.identifier.spage557en_HK
dc.identifier.epage561en_HK
dc.identifier.isiWOS:000168091300017-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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