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Article: The use of vaginal antimicrobial after large loop excision of transformation zone: A prospective randomised trial

TitleThe use of vaginal antimicrobial after large loop excision of transformation zone: A prospective randomised trial
Authors
KeywordsCervical intraepithelial neoplasia
Colposcopy
LEEP
LLETZ
Post LLETZ complications
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG
Citation
Bjog: An International Journal Of Obstetrics And Gynaecology, 2007, v. 114 n. 8, p. 970-976 How to Cite?
AbstractObjective: To investigate whether the use of an antibacterial vaginal pessary containing tetracycline and amphotericin B would reduce complications from large loop excision of the transformation zone (LLETZ). Design: Prospective randomised controlled trial. Setting: Department of Obstetrics and Gynaecology, University of Hong Kong. Population: A total of 321 women who underwent LLETZ. Methods: Women were randomised to either receiving an antimicrobial vaginal pessary twice a day for 14 days after LLETZ or no medication. Before LLETZ, endocervical and high vaginal swabs were taken for the detection of Chlamydia and other pathogens. All women were given a diary to record the degree of symptoms, such as vaginal discharge, bleeding and pain for 3 weeks. These were then compared between the two groups. Main outcome measures: Bleeding, vaginal discharge and pain after LLETZ. Results There was no significant difference in the total bleeding, vaginal discharge and pain scores between the two groups. However, for women who had positive endocervical or high vaginal swabs, the treatment group had significantly less bleeding in the second week (Z = -2.083, P = 0.037) and less overall vaginal discharge (Z = -2.024, P = 0.043). Conclusions: An antimicrobial vaginal pessary containing tetracycline and amphotericin B did not provide any significant benefit after LLETZ, except for a subgroup of women with positive vaginal or endocervical swabs. Given that this group of women cannot be identified before the procedure since swabs are not routinely taken, the use of routine prophylactic topical antibiotics cannot be recommended for the general population. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/87478
ISSN
2015 Impact Factor: 4.039
2015 SCImago Journal Rankings: 2.083
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KKLen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorTse, KYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:30:10Z-
dc.date.available2010-09-06T09:30:10Z-
dc.date.issued2007en_HK
dc.identifier.citationBjog: An International Journal Of Obstetrics And Gynaecology, 2007, v. 114 n. 8, p. 970-976en_HK
dc.identifier.issn1470-0328en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87478-
dc.description.abstractObjective: To investigate whether the use of an antibacterial vaginal pessary containing tetracycline and amphotericin B would reduce complications from large loop excision of the transformation zone (LLETZ). Design: Prospective randomised controlled trial. Setting: Department of Obstetrics and Gynaecology, University of Hong Kong. Population: A total of 321 women who underwent LLETZ. Methods: Women were randomised to either receiving an antimicrobial vaginal pessary twice a day for 14 days after LLETZ or no medication. Before LLETZ, endocervical and high vaginal swabs were taken for the detection of Chlamydia and other pathogens. All women were given a diary to record the degree of symptoms, such as vaginal discharge, bleeding and pain for 3 weeks. These were then compared between the two groups. Main outcome measures: Bleeding, vaginal discharge and pain after LLETZ. Results There was no significant difference in the total bleeding, vaginal discharge and pain scores between the two groups. However, for women who had positive endocervical or high vaginal swabs, the treatment group had significantly less bleeding in the second week (Z = -2.083, P = 0.037) and less overall vaginal discharge (Z = -2.024, P = 0.043). Conclusions: An antimicrobial vaginal pessary containing tetracycline and amphotericin B did not provide any significant benefit after LLETZ, except for a subgroup of women with positive vaginal or endocervical swabs. Given that this group of women cannot be identified before the procedure since swabs are not routinely taken, the use of routine prophylactic topical antibiotics cannot be recommended for the general population. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOGen_HK
dc.relation.ispartofBJOG: An International Journal of Obstetrics and Gynaecologyen_HK
dc.rightsBritish Journal of Obstetrics & Gynaecology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectCervical intraepithelial neoplasiaen_HK
dc.subjectColposcopyen_HK
dc.subjectLEEPen_HK
dc.subjectLLETZen_HK
dc.subjectPost LLETZ complicationsen_HK
dc.titleThe use of vaginal antimicrobial after large loop excision of transformation zone: A prospective randomised trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-5456&volume=114&issue=8&spage=970&epage=976&date=2007&atitle=The+use+of+vaginal+antimicrobial+after+large+loop+excision+of+transformation+zone:+a+prospective+randomised+trialen_HK
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1471-0528.2007.01417.xen_HK
dc.identifier.pmid17635487-
dc.identifier.scopuseid_2-s2.0-34447313384en_HK
dc.identifier.hkuros132018en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447313384&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue8en_HK
dc.identifier.spage970en_HK
dc.identifier.epage976en_HK
dc.identifier.isiWOS:000248521900008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridTse, KY=8876026900en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.citeulike1456364-

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