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Article: Mitomycin C and cisplatin enhanced the antitumor activity of p53-expressing adenovirus in cervical cancer cells

TitleMitomycin C and cisplatin enhanced the antitumor activity of p53-expressing adenovirus in cervical cancer cells
Authors
KeywordsChemotherapy
Cisplatin
Gene Transfer
Mitomycin C
P53
Issue Date2001
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp
Citation
Cancer Investigation, 2001, v. 19 n. 4, p. 360-368 How to Cite?
AbstractThis study investigated the enhanced antitumor activity of Ad5-p53 in combination with mitomycin C (MMC) or cisplatin (DDP) in cervical cancer cell lines SiHa and C-33A. MMC and DDP inhibited the growth of SiHa and C-33A cells in a dose-dependent manner, and the combination of MMC or DDP with Ad5-p53 showed a stronger growth inhibition than those treated with either Ad5-p53, MMC, or DDP alone. As evidenced by the formation of the ∼200 bp DNA ladder and the appearance of sub-G1 peak both MMC and DDP induced apoptosis in cervical cancer cells. Western blot analysis of p53 showed that MMC/DDP did not induce the increase of p53 protein in SiHa cells nor the increase of the cellular and nuclear p53 protein in Ad5-p53 transfected Saos-2 cells. Taken together, these results suggested that the combination of Ad5-p53 and MMC/DDP may serve as an effective therapeutic regime for human cervical cancer treatment.
Persistent Identifierhttp://hdl.handle.net/10722/87448
ISSN
2015 Impact Factor: 2.231
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, TGen_HK
dc.contributor.authorIp, SMen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:29:47Z-
dc.date.available2010-09-06T09:29:47Z-
dc.date.issued2001en_HK
dc.identifier.citationCancer Investigation, 2001, v. 19 n. 4, p. 360-368en_HK
dc.identifier.issn0735-7907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87448-
dc.description.abstractThis study investigated the enhanced antitumor activity of Ad5-p53 in combination with mitomycin C (MMC) or cisplatin (DDP) in cervical cancer cell lines SiHa and C-33A. MMC and DDP inhibited the growth of SiHa and C-33A cells in a dose-dependent manner, and the combination of MMC or DDP with Ad5-p53 showed a stronger growth inhibition than those treated with either Ad5-p53, MMC, or DDP alone. As evidenced by the formation of the ∼200 bp DNA ladder and the appearance of sub-G1 peak both MMC and DDP induced apoptosis in cervical cancer cells. Western blot analysis of p53 showed that MMC/DDP did not induce the increase of p53 protein in SiHa cells nor the increase of the cellular and nuclear p53 protein in Ad5-p53 transfected Saos-2 cells. Taken together, these results suggested that the combination of Ad5-p53 and MMC/DDP may serve as an effective therapeutic regime for human cervical cancer treatment.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.aspen_HK
dc.relation.ispartofCancer Investigationen_HK
dc.rightsCancer Investigation. Copyright © Informa Healthcare.en_HK
dc.subjectChemotherapyen_HK
dc.subjectCisplatinen_HK
dc.subjectGene Transferen_HK
dc.subjectMitomycin Cen_HK
dc.subjectP53en_HK
dc.titleMitomycin C and cisplatin enhanced the antitumor activity of p53-expressing adenovirus in cervical cancer cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0735-7907&volume=19&issue=4&spage=360&epage=368&date=2001&atitle=Mitomycin+C+and+cisplatin+enhanced+the+antitumor+activity+of+p53-expressing+adenovirus+in+cervical+cancer+cellsen_HK
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1081/CNV-100103131en_HK
dc.identifier.pmid11405176-
dc.identifier.scopuseid_2-s2.0-0035019750en_HK
dc.identifier.hkuros65263en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035019750&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue4en_HK
dc.identifier.spage360en_HK
dc.identifier.epage368en_HK
dc.identifier.isiWOS:000169919100005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuang, TG=7404962005en_HK
dc.identifier.scopusauthoridIp, SM=55041321600en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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