File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Single-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia

TitleSingle-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia
Authors
KeywordsChemotherapy
Gestational trophoblastic neoplasia
Methotrexate
Issue Date2006
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajog
Citation
American Journal Of Obstetrics And Gynecology, 2006, v. 195 n. 5, p. 1282-1286 How to Cite?
AbstractObjective: The objective of the study was to evaluate the effectiveness of single-dose methotrexate in women with low-risk gestational trophoblastic neoplasia. Study design: In this prospective observational cohort study, 105 women with low-risk gestational trophoblastic neoplasia were treated with an intravenous bolus of 100 mg/m2 of methotrexate followed by a 12-hour infusion of 200 mg/m2. If the human chorionic gonadotropin level fell 10-fold after 2 weeks, no further chemotherapy was given. Characteristics between the 2 groups with or without complete remission with this regimen were compared. Results: The overall complete remission rate with methotrexate was 84.8%, with 44.8% of women requiring a single dose of methotrexate alone. The pretreatment human chorionic gonadotropin level was found to be significantly higher in women who failed the single-dose methotrexate regimen (P = .001), and 10 of 11 patients with metastases required further doses. Conclusion: This regimen offers an effective option for women with low-risk gestational trophoblastic neoplasia without metastases and a low pretreatment human chorionic gonadotropin level. © 2006 Mosby, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/87440
ISSN
2015 Impact Factor: 4.681
2015 SCImago Journal Rankings: 2.255
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KKLen_HK
dc.contributor.authorHuang, Yen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorTse, KYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:29:41Z-
dc.date.available2010-09-06T09:29:41Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Obstetrics And Gynecology, 2006, v. 195 n. 5, p. 1282-1286en_HK
dc.identifier.issn0002-9378en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87440-
dc.description.abstractObjective: The objective of the study was to evaluate the effectiveness of single-dose methotrexate in women with low-risk gestational trophoblastic neoplasia. Study design: In this prospective observational cohort study, 105 women with low-risk gestational trophoblastic neoplasia were treated with an intravenous bolus of 100 mg/m2 of methotrexate followed by a 12-hour infusion of 200 mg/m2. If the human chorionic gonadotropin level fell 10-fold after 2 weeks, no further chemotherapy was given. Characteristics between the 2 groups with or without complete remission with this regimen were compared. Results: The overall complete remission rate with methotrexate was 84.8%, with 44.8% of women requiring a single dose of methotrexate alone. The pretreatment human chorionic gonadotropin level was found to be significantly higher in women who failed the single-dose methotrexate regimen (P = .001), and 10 of 11 patients with metastases required further doses. Conclusion: This regimen offers an effective option for women with low-risk gestational trophoblastic neoplasia without metastases and a low pretreatment human chorionic gonadotropin level. © 2006 Mosby, Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajogen_HK
dc.relation.ispartofAmerican Journal of Obstetrics and Gynecologyen_HK
dc.rightsAmerican Journal of Obstetrics and Gynecology. Copyright © Mosby, Inc.en_HK
dc.subjectChemotherapyen_HK
dc.subjectGestational trophoblastic neoplasiaen_HK
dc.subjectMethotrexateen_HK
dc.titleSingle-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9378&volume=195 &issue=Issue 5&spage=1282&epage=1286&date=2006&atitle=Single-dose+methotrexate+regimen+in+the+treatment+of+low-risk+gestational+trophoblastic+neoplasiaen_HK
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ajog.2006.03.048en_HK
dc.identifier.pmid16723109-
dc.identifier.scopuseid_2-s2.0-33750378763en_HK
dc.identifier.hkuros147211en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750378763&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume195en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1282en_HK
dc.identifier.epage1286en_HK
dc.identifier.isiWOS:000242035700015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK
dc.identifier.scopusauthoridHuang, Y=15044554300en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridTse, KY=8876026900en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats