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Article: Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women

TitleBioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women
Authors
KeywordshCG
Intramuscular
Obese
Subcutaneous
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2003, v. 18 n. 11, p. 2294-2297 How to Cite?
AbstractBackground: Obese women require higher gonadotrophin doses for ovarian stimulation and to trigger ovulation. The bioavailability of a drug is affected by its route of administration. Herein, the bioavailability of hCG was compared after intramuscular (i.m.) or subcutaneous (s.c.) injection in obese and non-obese women. Methods: Twenty four Chinese women, 12 with a body mass index (BMI) ≥28 kg/m 2 and 12 with a BMI of 20-25 kg/m 2 were recruited as the obese and non-obese groups respectively. A single hCG injection was given intramuscularly on one occasion, and subcutaneously on a second occasion, separated by 4 weeks. Blood samples were taken at intervals for the pharmacokinetic study of hCG. Results: Examination of the hCG plasma concentration-time curve showed the area under the curve (AUC) and maximum concentration (C max) of hCG to be significantly higher after i.m. injection than after s.c. injection in both the obese and non-obese groups. However, the AUC and C max values in obese women were significantly lower than in non-obese women, irrespective of whether i.m. or s.c. dosing was employed. Conclusions: Intramuscular dosing of hCG provided better bioavailability than s.c. dosing, but bioavailability was significantly less in obese women than in non-obese women.
Persistent Identifierhttp://hdl.handle.net/10722/87432
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CCWen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorChan, MMYen_HK
dc.contributor.authorTang, OSen_HK
dc.contributor.authorLau, EYLen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:29:35Z-
dc.date.available2010-09-06T09:29:35Z-
dc.date.issued2003en_HK
dc.identifier.citationHuman Reproduction, 2003, v. 18 n. 11, p. 2294-2297en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87432-
dc.description.abstractBackground: Obese women require higher gonadotrophin doses for ovarian stimulation and to trigger ovulation. The bioavailability of a drug is affected by its route of administration. Herein, the bioavailability of hCG was compared after intramuscular (i.m.) or subcutaneous (s.c.) injection in obese and non-obese women. Methods: Twenty four Chinese women, 12 with a body mass index (BMI) ≥28 kg/m 2 and 12 with a BMI of 20-25 kg/m 2 were recruited as the obese and non-obese groups respectively. A single hCG injection was given intramuscularly on one occasion, and subcutaneously on a second occasion, separated by 4 weeks. Blood samples were taken at intervals for the pharmacokinetic study of hCG. Results: Examination of the hCG plasma concentration-time curve showed the area under the curve (AUC) and maximum concentration (C max) of hCG to be significantly higher after i.m. injection than after s.c. injection in both the obese and non-obese groups. However, the AUC and C max values in obese women were significantly lower than in non-obese women, irrespective of whether i.m. or s.c. dosing was employed. Conclusions: Intramuscular dosing of hCG provided better bioavailability than s.c. dosing, but bioavailability was significantly less in obese women than in non-obese women.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjecthCGen_HK
dc.subjectIntramuscularen_HK
dc.subjectObeseen_HK
dc.subjectSubcutaneousen_HK
dc.titleBioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=18&issue=11&spage=2294&epage=2297&date=2003&atitle=Bioavailability+of+hCG+after+intramuscular+or+subcutaneous+injection+in+obese+and+non-obese+womenen_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/humrep/deg446en_HK
dc.identifier.pmid14585876-
dc.identifier.scopuseid_2-s2.0-0242606906en_HK
dc.identifier.hkuros87628en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0242606906&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2294en_HK
dc.identifier.epage2297en_HK
dc.identifier.isiWOS:000186447500011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, CCW=26643394500en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridChan, MMY=7402597730en_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridLau, EYL=7103086093en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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