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Article: Molecular analysis of the androgen receptor gene in Hong Kong Chinese infertile men

TitleMolecular analysis of the androgen receptor gene in Hong Kong Chinese infertile men
Authors
KeywordsAndrogen receptor
CAG repeat
Male infertility
Issue Date2003
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1058-0468
Citation
Journal Of Assisted Reproduction And Genetics, 2003, v. 20 n. 6, p. 227-233 How to Cite?
AbstractPurpose: To investigate the relationship between CAG repeat length in the androgen receptor gene and impaired spermatogenesis in Hong Kong Chinese population. Methods: The CAG repeat region was amplified by polymerase chain reaction (PCR) in 85 nonobstructive azoospermic or severe oligozoospermic men, and 45 fertile males. The number of CAG repeat was analyzed by DNA sequencing. Serum FSH, LH, and testosterone levels were also determined in these men. Results: Among nonobstructive azoospermic males, three men (5.7%) possessed short CAG repeats (<16), and three (5.7%) other men possessed long CAG repeats (>30). Short CAG repeats (<16) were also found in two severe oligozoospermic males (6.3%). The incidence of infertile men with short or long CAG repeats is significantly higher in the azoospermic group (p = 0.03) but not in the severe oligozoospermic group (p = 0.17) when compared with the fertile controls. Conclusion: Our data suggest an association between CAG repeat lengths and impaired spermatogenesis in azoospermic males in our population.
Persistent Identifierhttp://hdl.handle.net/10722/87429
ISSN
2015 Impact Factor: 1.858
2015 SCImago Journal Rankings: 0.858
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, JYMen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorLau, EYLen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:29:33Z-
dc.date.available2010-09-06T09:29:33Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Assisted Reproduction And Genetics, 2003, v. 20 n. 6, p. 227-233en_HK
dc.identifier.issn1058-0468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87429-
dc.description.abstractPurpose: To investigate the relationship between CAG repeat length in the androgen receptor gene and impaired spermatogenesis in Hong Kong Chinese population. Methods: The CAG repeat region was amplified by polymerase chain reaction (PCR) in 85 nonobstructive azoospermic or severe oligozoospermic men, and 45 fertile males. The number of CAG repeat was analyzed by DNA sequencing. Serum FSH, LH, and testosterone levels were also determined in these men. Results: Among nonobstructive azoospermic males, three men (5.7%) possessed short CAG repeats (<16), and three (5.7%) other men possessed long CAG repeats (>30). Short CAG repeats (<16) were also found in two severe oligozoospermic males (6.3%). The incidence of infertile men with short or long CAG repeats is significantly higher in the azoospermic group (p = 0.03) but not in the severe oligozoospermic group (p = 0.17) when compared with the fertile controls. Conclusion: Our data suggest an association between CAG repeat lengths and impaired spermatogenesis in azoospermic males in our population.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1058-0468en_HK
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_HK
dc.subjectAndrogen receptoren_HK
dc.subjectCAG repeaten_HK
dc.subjectMale infertilityen_HK
dc.titleMolecular analysis of the androgen receptor gene in Hong Kong Chinese infertile menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-0468&volume=20&issue=6&spage=227&epage=233&date=2003&atitle=Molecular+analysis+of+the+androgen+receptor+gene+in+Hong+Kong+Chinese+infertile+menen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1024107528283en_HK
dc.identifier.pmid12877254-
dc.identifier.scopuseid_2-s2.0-0037634597en_HK
dc.identifier.hkuros80357en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037634597&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue6en_HK
dc.identifier.spage227en_HK
dc.identifier.epage233en_HK
dc.identifier.isiWOS:000183440900005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, JYM=7102607314en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridLau, EYL=7103086093en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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