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Article: Frequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancers

TitleFrequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancers
Authors
KeywordsBreast carcinoma
Cervical carcinoma
D-loop
Endometrial carcinoma
Mitochondrial DNA
Mitochondrial microsatellite instability
Ovarian carcinoma
Issue Date2005
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2005, v. 1042, p. 123-129 How to Cite?
AbstractWe analyzed the occurrence of mitochondrial microsatellite instability (mtMSI) in 262 pairs of female cancer tissues with the matched normal controls. mtMSI was detected in only 4 of 12 microsatellites found in the mitochondrial genome (3 in the D-loop and 1 in the 12S rRNA gene). Interestingly, 95.6% (87/91) of mtMSI was detected in the D-loop, namely, at nucleotide positions 303-315, 514-523, and 16184-16193. This demonstrates that the D-loop is a hotspot for mtMSI. Different incidences of mtMSI at these three microsatellites were found in the four cancer types (including cervical, endometrial, ovarian, and breast). Together with those mtMSI reported in other studies, the differential occurrence of mtMSI at each of the markers in the D-loop region was observed, indicating that the extent of mtMSI varies from one cancer to another. Although the mechanisms of generation and functional impact of mtMSI are still not clear, the high incidence of mtMSI in the D-loop and its broad distribution in human cancers render it a potential marker for cancer detection. © 2005 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/87428
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorNagley, Pen_HK
dc.date.accessioned2010-09-06T09:29:32Z-
dc.date.available2010-09-06T09:29:32Z-
dc.date.issued2005en_HK
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2005, v. 1042, p. 123-129en_HK
dc.identifier.issn0077-8923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87428-
dc.description.abstractWe analyzed the occurrence of mitochondrial microsatellite instability (mtMSI) in 262 pairs of female cancer tissues with the matched normal controls. mtMSI was detected in only 4 of 12 microsatellites found in the mitochondrial genome (3 in the D-loop and 1 in the 12S rRNA gene). Interestingly, 95.6% (87/91) of mtMSI was detected in the D-loop, namely, at nucleotide positions 303-315, 514-523, and 16184-16193. This demonstrates that the D-loop is a hotspot for mtMSI. Different incidences of mtMSI at these three microsatellites were found in the four cancer types (including cervical, endometrial, ovarian, and breast). Together with those mtMSI reported in other studies, the differential occurrence of mtMSI at each of the markers in the D-loop region was observed, indicating that the extent of mtMSI varies from one cancer to another. Although the mechanisms of generation and functional impact of mtMSI are still not clear, the high incidence of mtMSI in the D-loop and its broad distribution in human cancers render it a potential marker for cancer detection. © 2005 New York Academy of Sciences.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_HK
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_HK
dc.subjectBreast carcinomaen_HK
dc.subjectCervical carcinomaen_HK
dc.subjectD-loopen_HK
dc.subjectEndometrial carcinomaen_HK
dc.subjectMitochondrial DNAen_HK
dc.subjectMitochondrial microsatellite instabilityen_HK
dc.subjectOvarian carcinomaen_HK
dc.titleFrequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0077-8923&volume=1042&spage=123&epage=129&date=2005&atitle=Frequent+occurrence+of+mitochondrial+microsatellite+instability+in+the+D-Loop+region+of+human+cancersen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1196/annals.1338.012en_HK
dc.identifier.pmid15965053-
dc.identifier.scopuseid_2-s2.0-22044451763en_HK
dc.identifier.hkuros101872en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22044451763&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1042en_HK
dc.identifier.spage123en_HK
dc.identifier.epage129en_HK
dc.identifier.isiWOS:000230893400014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, Y=8678094600en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridNagley, P=7006184213en_HK

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