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Article: Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: A randomized, double-blinded placebo-controlled trial

TitleEffects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: A randomized, double-blinded placebo-controlled trial
Authors
KeywordsClomiphene-resistant
Metformin
Polycystic ovaries
Issue Date2001
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2001, v. 16 n. 8, p. 1625-1631 How to Cite?
AbstractBackground: Metformin, an insulin-sensitizing agent, has been used successfully as the first-line drug to induce ovulation in women with polycystic ovary syndrome. There are, however, very few studies evaluating metformin treatment in women with clomiphene citrate (CC)-resistant polycystic ovaries (PCO). Methods: Twenty infertile Chinese women aged <40 years, who had ultrasound features of PCO and remained anovulatory on CC, were randomized by computer using the sealed envelope method to receive placebo or metformin 500 mg three times a day for 3 months. Hormonal and metabolic profiles were determined before the therapy and were repeated after 3 months for women who failed to become pregnant within this period. Clomiphene was then added for one cycle to those women who did not ovulate after taking placebo or metformin alone. Results: The median ovulation rate in the placebo group was 0% (range: 0-50%) after placebo only and 6.9% (range: 0-50%) after placebo and CC, whereas the corresponding rates in the metformin group were 0% (range: 0-22%) and 0% (range: 0-22%) respectively. There was no improvement in the ovulation rate despite a significant reduction of body mass index, serum testosterone and fasting leptin concentrations in the metformin group. Conclusions: Metformin treatment may result in successful ovulation only in certain subgroups of these women.
Persistent Identifierhttp://hdl.handle.net/10722/87415
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:29:22Z-
dc.date.available2010-09-06T09:29:22Z-
dc.date.issued2001en_HK
dc.identifier.citationHuman Reproduction, 2001, v. 16 n. 8, p. 1625-1631en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87415-
dc.description.abstractBackground: Metformin, an insulin-sensitizing agent, has been used successfully as the first-line drug to induce ovulation in women with polycystic ovary syndrome. There are, however, very few studies evaluating metformin treatment in women with clomiphene citrate (CC)-resistant polycystic ovaries (PCO). Methods: Twenty infertile Chinese women aged <40 years, who had ultrasound features of PCO and remained anovulatory on CC, were randomized by computer using the sealed envelope method to receive placebo or metformin 500 mg three times a day for 3 months. Hormonal and metabolic profiles were determined before the therapy and were repeated after 3 months for women who failed to become pregnant within this period. Clomiphene was then added for one cycle to those women who did not ovulate after taking placebo or metformin alone. Results: The median ovulation rate in the placebo group was 0% (range: 0-50%) after placebo only and 6.9% (range: 0-50%) after placebo and CC, whereas the corresponding rates in the metformin group were 0% (range: 0-22%) and 0% (range: 0-22%) respectively. There was no improvement in the ovulation rate despite a significant reduction of body mass index, serum testosterone and fasting leptin concentrations in the metformin group. Conclusions: Metformin treatment may result in successful ovulation only in certain subgroups of these women.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectClomiphene-resistanten_HK
dc.subjectMetforminen_HK
dc.subjectPolycystic ovariesen_HK
dc.titleEffects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: A randomized, double-blinded placebo-controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=16&issue=8&spage=1625&epage=1631&date=2001&atitle=Effects+of+metformin+on+ovulation+rate,+hormonal+and+metabolic+profiles+in+women+with+clomiphene-resistant+polycystic+ovaries:+a+randomized,+double-blinded+placebo-controlled+trialen_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/humrep/16.8.1625-
dc.identifier.pmid11473953-
dc.identifier.scopuseid_2-s2.0-0034886493en_HK
dc.identifier.hkuros65291en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034886493&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1625en_HK
dc.identifier.epage1631en_HK
dc.identifier.isiWOS:000170441100015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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