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Article: Quantification of human papillomavirus DNA in the plasma of patients with cervical cancer

TitleQuantification of human papillomavirus DNA in the plasma of patients with cervical cancer
Authors
KeywordsCervical cancer
Human papillomavirus
Plasma DNA
Quantitative PCR
Issue Date2004
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/
Citation
International Journal Of Gynecological Cancer, 2004, v. 14 n. 5, p. 903-910 How to Cite?
AbstractPlasma human papillomavirus (HPV)-DNA level was measured to evaluate the clinical usefulness of circulating DNA for cervical cancer management. DNA extracted from pretreatment plasma of 50 cervical cancer patients and from serial longitudinal plasma of 21 patients was quantified for HPV16/HPV18 by means of quantitative polymerase chain reaction. Another 15 patients with low-grade lesion (LG), 18 patients with high-grade lesion (HG), and 96 normal individuals were studied as controls. Plasma HPV16-DNA was detectable in 50% of cancer patients. The incidence and median level were statistically higher than those in LG patients and normal, but similar to HG patients. Plasma HPV18-DNA was only detected in 6% of cancer patients and 1% of normal. Same type of HPV present in plasma was also detected in its primary tumor; and the level of plasma HPV16-DNA was dependent on the viral load in primary tumor. Plasma HPV-DNA was not detected in 16 of 21 patients after treatment, and those patients had complete response to therapy. HPV-DNA persisted or reappeared in five patients after treatment (one had persistent disease and another had recurrence). Plasma HPV-DNA might be a valuable marker for monitoring therapeutic response and disease progression in cervical cancer.
Persistent Identifierhttp://hdl.handle.net/10722/87371
ISSN
2015 Impact Factor: 2.116
2015 SCImago Journal Rankings: 0.830
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, HJen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorTsang, PCKen_HK
dc.contributor.authorYip, AMWen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorWong, LCen_HK
dc.contributor.authorNg, TYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:28:48Z-
dc.date.available2010-09-06T09:28:48Z-
dc.date.issued2004en_HK
dc.identifier.citationInternational Journal Of Gynecological Cancer, 2004, v. 14 n. 5, p. 903-910en_HK
dc.identifier.issn1048-891Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/87371-
dc.description.abstractPlasma human papillomavirus (HPV)-DNA level was measured to evaluate the clinical usefulness of circulating DNA for cervical cancer management. DNA extracted from pretreatment plasma of 50 cervical cancer patients and from serial longitudinal plasma of 21 patients was quantified for HPV16/HPV18 by means of quantitative polymerase chain reaction. Another 15 patients with low-grade lesion (LG), 18 patients with high-grade lesion (HG), and 96 normal individuals were studied as controls. Plasma HPV16-DNA was detectable in 50% of cancer patients. The incidence and median level were statistically higher than those in LG patients and normal, but similar to HG patients. Plasma HPV18-DNA was only detected in 6% of cancer patients and 1% of normal. Same type of HPV present in plasma was also detected in its primary tumor; and the level of plasma HPV16-DNA was dependent on the viral load in primary tumor. Plasma HPV-DNA was not detected in 16 of 21 patients after treatment, and those patients had complete response to therapy. HPV-DNA persisted or reappeared in five patients after treatment (one had persistent disease and another had recurrence). Plasma HPV-DNA might be a valuable marker for monitoring therapeutic response and disease progression in cervical cancer.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/en_HK
dc.relation.ispartofInternational Journal of Gynecological Canceren_HK
dc.subjectCervical canceren_HK
dc.subjectHuman papillomavirusen_HK
dc.subjectPlasma DNAen_HK
dc.subjectQuantitative PCRen_HK
dc.titleQuantification of human papillomavirus DNA in the plasma of patients with cervical canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1048-891X&volume=14&spage=903&epage=910&date=2004&atitle=Quantification+of+human+papillomavirus+DNA+in+the+plasma+of+patients+with+cervical+canceren_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1048-891X.2004.014528.xen_HK
dc.identifier.pmid15361202-
dc.identifier.scopuseid_2-s2.0-4544331720en_HK
dc.identifier.hkuros100607en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4544331720&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue5en_HK
dc.identifier.spage903en_HK
dc.identifier.epage910en_HK
dc.identifier.isiWOS:000223822000025-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, HJ=7408624370en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridTsang, PCK=7102404070en_HK
dc.identifier.scopusauthoridYip, AMW=19838748300en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridWong, LC=55436382200en_HK
dc.identifier.scopusauthoridNg, TY=7402229853en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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