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Article: High frequency of mitochondrial genome instability in human endometrial carcinomas

TitleHigh frequency of mitochondrial genome instability in human endometrial carcinomas
Authors
KeywordsD-loop
Endometrial carcinoma
Mitochondrial DNA
Mitochondrial microsatellite instability
Issue Date2003
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2003, v. 89 n. 4, p. 697-701 How to Cite?
AbstractTo investigate the occurrence of somatic mitochondrial DNA (mtDNA) mutations in human primary endometrial carcinomas, we sequenced the D-loop region, the 12S and 16S rRNA genes of mtDNA of cancer tissues and their matched normal controls. About 56% (28 out of 50) of cases carry one or more somatic changes in mtDNA including deletion, point mutation and mitochondrial microsatellite instability (mtMSI), namely the change in length of short base-repetitive sequences of mtDNA. In particular, mtMSI was frequently detected in 89% (25 out of 28) of all the cases carrying somatic changes followed by point mutations (25%; seven out of 28) and deletion (3.5%; one out of 28). The CCCCCTCCCC sequences located in the Hypervariable Regions I and II of the D-loop and 12S rRNA gene are instability hot spot regions in endometrial carcinomas. It is suggested that errors in replication may account for the high frequency of mtMSI in human endometrial carcinomas. The relatively high prevalence of mtMSI may be a potential new tool for detection of endometrial cancer. © 2003 Cancer Research UK.
Persistent Identifierhttp://hdl.handle.net/10722/87333
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorYang, HJen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorTsang, PCKen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorChiu, PMen_HK
dc.contributor.authorNg, TYen_HK
dc.contributor.authorWong, LCen_HK
dc.contributor.authorNagley, Pen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:28:19Z-
dc.date.available2010-09-06T09:28:19Z-
dc.date.issued2003en_HK
dc.identifier.citationBritish Journal Of Cancer, 2003, v. 89 n. 4, p. 697-701en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87333-
dc.description.abstractTo investigate the occurrence of somatic mitochondrial DNA (mtDNA) mutations in human primary endometrial carcinomas, we sequenced the D-loop region, the 12S and 16S rRNA genes of mtDNA of cancer tissues and their matched normal controls. About 56% (28 out of 50) of cases carry one or more somatic changes in mtDNA including deletion, point mutation and mitochondrial microsatellite instability (mtMSI), namely the change in length of short base-repetitive sequences of mtDNA. In particular, mtMSI was frequently detected in 89% (25 out of 28) of all the cases carrying somatic changes followed by point mutations (25%; seven out of 28) and deletion (3.5%; one out of 28). The CCCCCTCCCC sequences located in the Hypervariable Regions I and II of the D-loop and 12S rRNA gene are instability hot spot regions in endometrial carcinomas. It is suggested that errors in replication may account for the high frequency of mtMSI in human endometrial carcinomas. The relatively high prevalence of mtMSI may be a potential new tool for detection of endometrial cancer. © 2003 Cancer Research UK.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectD-loopen_HK
dc.subjectEndometrial carcinomaen_HK
dc.subjectMitochondrial DNAen_HK
dc.subjectMitochondrial microsatellite instabilityen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshDNA Mutational Analysisen_HK
dc.subject.meshDNA, Mitochondrial - blood - geneticsen_HK
dc.subject.meshDinucleotide Repeatsen_HK
dc.subject.meshEndometrial Neoplasms - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Deletionen_HK
dc.subject.meshGenome, Humanen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphocytes - metabolismen_HK
dc.subject.meshMicrosatellite Repeats - geneticsen_HK
dc.subject.meshMitochondria - geneticsen_HK
dc.subject.meshMutationen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshRNA, Neoplasm - analysisen_HK
dc.subject.meshRNA, Ribosomal - geneticsen_HK
dc.subject.meshRNA, Ribosomal, 16S - geneticsen_HK
dc.titleHigh frequency of mitochondrial genome instability in human endometrial carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=89&issue=4&spage=697&epage=701&date=2003&atitle=High+frequency+of+mitochondrial+genome+instability+in+human+endometrial+carcinomasen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.bjc.6601110en_HK
dc.identifier.pmid12915881en_HK
dc.identifier.scopuseid_2-s2.0-0042233920en_HK
dc.identifier.hkuros86068en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042233920&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue4en_HK
dc.identifier.spage697en_HK
dc.identifier.epage701en_HK
dc.identifier.isiWOS:000184799100018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridYang, HJ=7408624370en_HK
dc.identifier.scopusauthoridWang, Y=8637619000en_HK
dc.identifier.scopusauthoridTsang, PCK=7102404070en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridChiu, PM=7103182596en_HK
dc.identifier.scopusauthoridNg, TY=7402229853en_HK
dc.identifier.scopusauthoridWong, LC=7402092003en_HK
dc.identifier.scopusauthoridNagley, P=7006184213en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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