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Article: Intracervical sodium nitroprusside versus vaginal misoprostol in first trimester surgical termination of pregnancy: A randomized double-blinded controlled trial

TitleIntracervical sodium nitroprusside versus vaginal misoprostol in first trimester surgical termination of pregnancy: A randomized double-blinded controlled trial
Authors
KeywordsMisoprostol
Nitric oxide donor
Sodium nitroprusside
Surgical termination of pregnancy
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2005, v. 20 n. 3, p. 829-833 How to Cite?
AbstractBackground: Results from small-scale randomized studies on the effectiveness of different preparations of nitric oxide donors in cervical priming before first trimester termination of pregnancies are not consistent. We compared sodium nitroprusside gel to misoprostol, the standard agent for cervical priming in this randomized double-blinded controlled trial. Methods: Two hundred pregnant patients between 8 to 12 weeks admitted for surgical termination of pregnancy were recruited. They were randomized into either 400 μg vaginal misoprostol and intracervical placebo gel, or 10 mg intracervical sodium nitroprusside gel and placebo tablets 3 h before the procedure. The baseline cervical dilatation and cumulative force required to dilate the cervix from 4 to 9 mm were measured with a tonometer. Blood pressure was measured and side effects were assessed. Results: The cumulative force to dilate the cervix from 4 to 9 mm was significantly higher in the sodium nitroprusside group, and the difference remained when a sub-group analysis was performed according to parity. Baseline cervical dilatation, duration of operation and operative blood loss were all in favour of misoprostol. Transient drop in blood pressure was observed after sodium nitroprusside treatment. Conclusions: Intracervical sodium nitroprusside is not as effective as misoprostol in cervical priming. © The Author 2004. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/87300
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CCWen_HK
dc.contributor.authorTang, OSen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorLi, CFen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:27:54Z-
dc.date.available2010-09-06T09:27:54Z-
dc.date.issued2005en_HK
dc.identifier.citationHuman Reproduction, 2005, v. 20 n. 3, p. 829-833en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87300-
dc.description.abstractBackground: Results from small-scale randomized studies on the effectiveness of different preparations of nitric oxide donors in cervical priming before first trimester termination of pregnancies are not consistent. We compared sodium nitroprusside gel to misoprostol, the standard agent for cervical priming in this randomized double-blinded controlled trial. Methods: Two hundred pregnant patients between 8 to 12 weeks admitted for surgical termination of pregnancy were recruited. They were randomized into either 400 μg vaginal misoprostol and intracervical placebo gel, or 10 mg intracervical sodium nitroprusside gel and placebo tablets 3 h before the procedure. The baseline cervical dilatation and cumulative force required to dilate the cervix from 4 to 9 mm were measured with a tonometer. Blood pressure was measured and side effects were assessed. Results: The cumulative force to dilate the cervix from 4 to 9 mm was significantly higher in the sodium nitroprusside group, and the difference remained when a sub-group analysis was performed according to parity. Baseline cervical dilatation, duration of operation and operative blood loss were all in favour of misoprostol. Transient drop in blood pressure was observed after sodium nitroprusside treatment. Conclusions: Intracervical sodium nitroprusside is not as effective as misoprostol in cervical priming. © The Author 2004. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectMisoprostolen_HK
dc.subjectNitric oxide donoren_HK
dc.subjectSodium nitroprussideen_HK
dc.subjectSurgical termination of pregnancyen_HK
dc.titleIntracervical sodium nitroprusside versus vaginal misoprostol in first trimester surgical termination of pregnancy: A randomized double-blinded controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=20&issue=3&spage=829&epage=833&date=2005&atitle=Intracervical+sodium+nitroprusside+versus+vaginal+misoprostol+in+first+trimester+surgical+termination+of+pregnancy:+a+randomized+double-blinded+controlled+trialen_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/humrep/deh676en_HK
dc.identifier.pmid15608034-
dc.identifier.scopuseid_2-s2.0-15844417256en_HK
dc.identifier.hkuros97415en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15844417256&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue3en_HK
dc.identifier.spage829en_HK
dc.identifier.epage833en_HK
dc.identifier.isiWOS:000227129300041-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, CCW=26643394500en_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridLi, CF=7501686453en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.citeulike101325-

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