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Article: A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification

TitleA retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification
Authors
Keywords"Favor neoplasia"
"NOS"
AGC
AGUS
Significant pathology
Issue Date2003
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 2003, v. 91 n. 3, p. 603-607 How to Cite?
AbstractObjectives The Bethesda system for reporting cervicovaginal cytologic diagnoses was recently revised in 2001. Pathologists are required to report not only whether the smear favors neoplastic changes, but also the origin of the abnormal cells. In this study, archival smears were reviewed to evaluate the usefulness of the new classification. Methods Smears having atypical glandular cells taken between January 1995 and December 1997 were reviewed and subclassified according to the revised Bethesda classification. Case records were then reviewed and cases with discrepancies between the cytological evaluation and corresponding final histological diagnoses were further reviewed. Results There were 138 smears reviewed. The mean age of the patients was 47 (range, 18 to 78). Thirty-four smears favored neoplasia and 104 favored "NOS" ("not otherwise specified"). Sixty smears favored endocervical origin and 78 endometrial origin. Forty-three patients (31%) had significant pathologies, including 12 (8.7%) patients with high-grade CIN, 2 (1.4%) with low-grade CIN, 5 (3.6%) with HPV infection, 7 (5.1%) with carcinoma of the corpus, 1 (0.7%) with cervical adenocarcinoma in situ, 4 (2.9%) with adenocarcinoma of the cervix, 3 (2.2%) with endometrial hyperplasia, and 5 (3.6%) with carcinoma of the ovary. Two (1.4%) patients had double primary female genital malignancies and 2 patients (1.4%) had extragenital malignancies. Significant correlation was found between smears "favor neoplasia" and a final diagnosis with significant pathology (χ 2 test, P < 0.05). Significant association was found between AGC favored endocervical origin and a final diagnosis with cervical diseases (χ 2 test, P < 0.05). Four of the 43 patients who had significant pathologies had lesions found during their subsequent visits and all of them had cervical smears classified as AGC "favor neoplasia". Conclusions AGC found on cervical smears are an indication for early and intensive investigation. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/87297
ISSN
2014 Impact Factor: 3.774
2014 SCImago Journal Rankings: 1.575
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTam, KFen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorLiu, KLen_HK
dc.contributor.authorNg, TYen_HK
dc.contributor.authorPun, TCen_HK
dc.contributor.authorChan, YMen_HK
dc.contributor.authorWong, LCen_HK
dc.contributor.authorNg, AWYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:27:52Z-
dc.date.available2010-09-06T09:27:52Z-
dc.date.issued2003en_HK
dc.identifier.citationGynecologic Oncology, 2003, v. 91 n. 3, p. 603-607en_HK
dc.identifier.issn0090-8258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87297-
dc.description.abstractObjectives The Bethesda system for reporting cervicovaginal cytologic diagnoses was recently revised in 2001. Pathologists are required to report not only whether the smear favors neoplastic changes, but also the origin of the abnormal cells. In this study, archival smears were reviewed to evaluate the usefulness of the new classification. Methods Smears having atypical glandular cells taken between January 1995 and December 1997 were reviewed and subclassified according to the revised Bethesda classification. Case records were then reviewed and cases with discrepancies between the cytological evaluation and corresponding final histological diagnoses were further reviewed. Results There were 138 smears reviewed. The mean age of the patients was 47 (range, 18 to 78). Thirty-four smears favored neoplasia and 104 favored "NOS" ("not otherwise specified"). Sixty smears favored endocervical origin and 78 endometrial origin. Forty-three patients (31%) had significant pathologies, including 12 (8.7%) patients with high-grade CIN, 2 (1.4%) with low-grade CIN, 5 (3.6%) with HPV infection, 7 (5.1%) with carcinoma of the corpus, 1 (0.7%) with cervical adenocarcinoma in situ, 4 (2.9%) with adenocarcinoma of the cervix, 3 (2.2%) with endometrial hyperplasia, and 5 (3.6%) with carcinoma of the ovary. Two (1.4%) patients had double primary female genital malignancies and 2 patients (1.4%) had extragenital malignancies. Significant correlation was found between smears "favor neoplasia" and a final diagnosis with significant pathology (χ 2 test, P < 0.05). Significant association was found between AGC favored endocervical origin and a final diagnosis with cervical diseases (χ 2 test, P < 0.05). Four of the 43 patients who had significant pathologies had lesions found during their subsequent visits and all of them had cervical smears classified as AGC "favor neoplasia". Conclusions AGC found on cervical smears are an indication for early and intensive investigation. © 2003 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_HK
dc.relation.ispartofGynecologic Oncologyen_HK
dc.subject"Favor neoplasia"en_HK
dc.subject"NOS"en_HK
dc.subjectAGCen_HK
dc.subjectAGUSen_HK
dc.subjectSignificant pathologyen_HK
dc.subject.meshAdenocarcinoma - diagnosis - pathologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshCarcinoma in Situ - diagnosis - pathologyen_HK
dc.subject.meshCervical Intraepithelial Neoplasia - diagnosis - pathologyen_HK
dc.subject.meshCervix Uteri - pathologyen_HK
dc.subject.meshEndometrial Hyperplasia - diagnosis - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshUterine Cervical Neoplasms - diagnosis - pathologyen_HK
dc.subject.meshVaginal Smearsen_HK
dc.titleA retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classificationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0090-8258&volume=91&issue=3&spage=603&epage=607 &date=2003&atitle=A+retrospective+review+on+atypical+glandular+cells+of+undetermined+significance+(AGUS)+using+the+Bethesda+2001+classificationen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ygyno.2003.08.029en_HK
dc.identifier.pmid14675684-
dc.identifier.scopuseid_2-s2.0-1642272865en_HK
dc.identifier.hkuros86088en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642272865&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue3en_HK
dc.identifier.spage603en_HK
dc.identifier.epage607en_HK
dc.identifier.isiWOS:000187455100023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTam, KF=35622901400en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridLiu, KL=7404200677en_HK
dc.identifier.scopusauthoridNg, TY=7402229853en_HK
dc.identifier.scopusauthoridPun, TC=7005509306en_HK
dc.identifier.scopusauthoridChan, YM=7403676661en_HK
dc.identifier.scopusauthoridWong, LC=7402092003en_HK
dc.identifier.scopusauthoridNg, AWY=36850764000en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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