Article: A retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification

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TitleA retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification
AuthorsTam, KF1 2
Cheung, ANY1
Liu, KL1
Ng, TY1
Pun, TC1
Chan, YM1
Wong, LC1
Ng, AWY1
Ngan, HYS1
Keywords"Favor neoplasia"
"NOS"
AGC
AGUS
Significant pathology
Issue Date2003
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
CitationGynecologic Oncology, 2003, v. 91 n. 3, p. 603-607 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ygyno.2003.08.029
AbstractObjectives The Bethesda system for reporting cervicovaginal cytologic diagnoses was recently revised in 2001. Pathologists are required to report not only whether the smear favors neoplastic changes, but also the origin of the abnormal cells. In this study, archival smears were reviewed to evaluate the usefulness of the new classification. Methods Smears having atypical glandular cells taken between January 1995 and December 1997 were reviewed and subclassified according to the revised Bethesda classification. Case records were then reviewed and cases with discrepancies between the cytological evaluation and corresponding final histological diagnoses were further reviewed. Results There were 138 smears reviewed. The mean age of the patients was 47 (range, 18 to 78). Thirty-four smears favored neoplasia and 104 favored "NOS" ("not otherwise specified"). Sixty smears favored endocervical origin and 78 endometrial origin. Forty-three patients (31%) had significant pathologies, including 12 (8.7%) patients with high-grade CIN, 2 (1.4%) with low-grade CIN, 5 (3.6%) with HPV infection, 7 (5.1%) with carcinoma of the corpus, 1 (0.7%) with cervical adenocarcinoma in situ, 4 (2.9%) with adenocarcinoma of the cervix, 3 (2.2%) with endometrial hyperplasia, and 5 (3.6%) with carcinoma of the ovary. Two (1.4%) patients had double primary female genital malignancies and 2 patients (1.4%) had extragenital malignancies. Significant correlation was found between smears "favor neoplasia" and a final diagnosis with significant pathology (χ 2 test, P < 0.05). Significant association was found between AGC favored endocervical origin and a final diagnosis with cervical diseases (χ 2 test, P < 0.05). Four of the 43 patients who had significant pathologies had lesions found during their subsequent visits and all of them had cervical smears classified as AGC "favor neoplasia". Conclusions AGC found on cervical smears are an indication for early and intensive investigation. © 2003 Elsevier Inc. All rights reserved.
ISSN0090-8258
2011 Impact Factor: 3.888
2011 SCImago Journal Rankings: 0.374
DOIhttp://dx.doi.org/10.1016/j.ygyno.2003.08.029
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTam, KF
dc.contributor.authorCheung, ANY
dc.contributor.authorLiu, KL
dc.contributor.authorNg, TY
dc.contributor.authorPun, TC
dc.contributor.authorChan, YM
dc.contributor.authorWong, LC
dc.contributor.authorNg, AWY
dc.contributor.authorNgan, HYS
dc.date.accessioned2010-09-06T09:27:52Z
dc.date.available2010-09-06T09:27:52Z
dc.date.issued2003
dc.description.abstractObjectives The Bethesda system for reporting cervicovaginal cytologic diagnoses was recently revised in 2001. Pathologists are required to report not only whether the smear favors neoplastic changes, but also the origin of the abnormal cells. In this study, archival smears were reviewed to evaluate the usefulness of the new classification. Methods Smears having atypical glandular cells taken between January 1995 and December 1997 were reviewed and subclassified according to the revised Bethesda classification. Case records were then reviewed and cases with discrepancies between the cytological evaluation and corresponding final histological diagnoses were further reviewed. Results There were 138 smears reviewed. The mean age of the patients was 47 (range, 18 to 78). Thirty-four smears favored neoplasia and 104 favored "NOS" ("not otherwise specified"). Sixty smears favored endocervical origin and 78 endometrial origin. Forty-three patients (31%) had significant pathologies, including 12 (8.7%) patients with high-grade CIN, 2 (1.4%) with low-grade CIN, 5 (3.6%) with HPV infection, 7 (5.1%) with carcinoma of the corpus, 1 (0.7%) with cervical adenocarcinoma in situ, 4 (2.9%) with adenocarcinoma of the cervix, 3 (2.2%) with endometrial hyperplasia, and 5 (3.6%) with carcinoma of the ovary. Two (1.4%) patients had double primary female genital malignancies and 2 patients (1.4%) had extragenital malignancies. Significant correlation was found between smears "favor neoplasia" and a final diagnosis with significant pathology (χ 2 test, P < 0.05). Significant association was found between AGC favored endocervical origin and a final diagnosis with cervical diseases (χ 2 test, P < 0.05). Four of the 43 patients who had significant pathologies had lesions found during their subsequent visits and all of them had cervical smears classified as AGC "favor neoplasia". Conclusions AGC found on cervical smears are an indication for early and intensive investigation. © 2003 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationGynecologic Oncology, 2003, v. 91 n. 3, p. 603-607 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ygyno.2003.08.029
dc.identifier.doihttp://dx.doi.org/10.1016/j.ygyno.2003.08.029
dc.identifier.epage607
dc.identifier.hkuros86088
dc.identifier.isiWOS:000187455100023
dc.identifier.issn0090-8258
2011 Impact Factor: 3.888
2011 SCImago Journal Rankings: 0.374
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid14675684
dc.identifier.scopuseid_2-s2.0-1642272865
dc.identifier.spage603
dc.identifier.urihttp://hdl.handle.net/10722/87297
dc.identifier.volume91
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
dc.publisher.placeUnited States
dc.relation.ispartofGynecologic Oncology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdenocarcinoma - diagnosis - pathology
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCarcinoma in Situ - diagnosis - pathology
dc.subject.meshCervical Intraepithelial Neoplasia - diagnosis - pathology
dc.subject.meshCervix Uteri - pathology
dc.subject.meshEndometrial Hyperplasia - diagnosis - pathology
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshRetrospective Studies
dc.subject.meshUterine Cervical Neoplasms - diagnosis - pathology
dc.subject.meshVaginal Smears
dc.subject"Favor neoplasia"
dc.subject"NOS"
dc.subjectAGC
dc.subjectAGUS
dc.subjectSignificant pathology
dc.titleA retrospective review on atypical glandular cells of undetermined significance (AGUS) using the Bethesda 2001 classification
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong