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Article: High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas

TitleHigh incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas
Authors
Issue Date2001
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2001, v. 61 n. 16, p. 5998-6001 How to Cite?
AbstractTo investigate the potential role of somatic mitochondrial DNA (mtDNA) mutations in tumorigenesis, the occurrence of mutations in mtDNA of ovarian carcinomas was studied. We sequenced the D-loop region of mtDNA of 15 primary ovarian carcinomas and their matched normal controls. Somatic mtDNA mutations were detected in 20% (3 of 15) tumor samples carrying single or multiple changes. Complete sequence analysis of the mtDNA genomes of another 10 pairs of primary ovarian carcinomas and control tissues revealed somatic mtDNA mutations in 60% (6 of 10) of tumor samples. Most of these mutations were homoplasmic, and most were T→C or G→A transitions, but one represented a differential length within a run of identical C residues. A region of mtDNA sequence including the 16S and 12S rRNA genes, the D-loop and the cytochrome b gene, may represent the zone of preferred mtDNA mutation in ovarian cancer. The high incidence of mtDNA mutations found in ovarian carcinomas and other human cancers suggests that genetic instability of mtDNA might play a significant role in tumori-genesis.
Persistent Identifierhttp://hdl.handle.net/10722/87295
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorHong Hui Shien_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorPui Man Chiuen_HK
dc.contributor.authorTsin Wah Leungen_HK
dc.contributor.authorNagley, Pen_HK
dc.contributor.authorLing Wong Wongen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:27:50Z-
dc.date.available2010-09-06T09:27:50Z-
dc.date.issued2001en_HK
dc.identifier.citationCancer Research, 2001, v. 61 n. 16, p. 5998-6001en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87295-
dc.description.abstractTo investigate the potential role of somatic mitochondrial DNA (mtDNA) mutations in tumorigenesis, the occurrence of mutations in mtDNA of ovarian carcinomas was studied. We sequenced the D-loop region of mtDNA of 15 primary ovarian carcinomas and their matched normal controls. Somatic mtDNA mutations were detected in 20% (3 of 15) tumor samples carrying single or multiple changes. Complete sequence analysis of the mtDNA genomes of another 10 pairs of primary ovarian carcinomas and control tissues revealed somatic mtDNA mutations in 60% (6 of 10) of tumor samples. Most of these mutations were homoplasmic, and most were T→C or G→A transitions, but one represented a differential length within a run of identical C residues. A region of mtDNA sequence including the 16S and 12S rRNA genes, the D-loop and the cytochrome b gene, may represent the zone of preferred mtDNA mutation in ovarian cancer. The high incidence of mtDNA mutations found in ovarian carcinomas and other human cancers suggests that genetic instability of mtDNA might play a significant role in tumori-genesis.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subject.meshDNA, Mitochondrial - blood - geneticsen_HK
dc.subject.meshDNA, Neoplasm - blood - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMutationen_HK
dc.subject.meshOvarian Neoplasms - geneticsen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshRNA, Ribosomal, 16S - geneticsen_HK
dc.titleHigh incidence of somatic mitochondrial DNA mutations in human ovarian carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=61&spage=5998&epage=6001&date=2001&atitle=High+incidence+of+somatic+mitochondrial+DNA+mutations+in+human+ovarian+carcinomasen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11507041-
dc.identifier.scopuseid_2-s2.0-0035882029en_HK
dc.identifier.hkuros65309en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035882029&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue16en_HK
dc.identifier.spage5998en_HK
dc.identifier.epage6001en_HK
dc.identifier.isiWOS:000170521100009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridHong Hui Shi=36946575400en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridPui Man Chiu=7409744652en_HK
dc.identifier.scopusauthoridTsin Wah Leung=7409562861en_HK
dc.identifier.scopusauthoridNagley, P=7006184213en_HK
dc.identifier.scopusauthoridLing Wong Wong=7409528124en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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