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Article: A prospective, open, randomized clinical study to assess the efficacy and safety of two gonadotropin preparations administered in WHO Group II anovulatory subfertile women

TitleA prospective, open, randomized clinical study to assess the efficacy and safety of two gonadotropin preparations administered in WHO Group II anovulatory subfertile women
Authors
KeywordsGonadotropins
Ovulation induction
WHO Group II anovulation
Issue Date1998
PublisherBlackwell Publishing Asia.
Citation
Journal Of Obstetrics And Gynaecology Research, 1998, v. 24 n. 5, p. 355-361 How to Cite?
AbstractObjective: To assess the efficacy and safety of 2 gonadotropin preparations in inducing ovulation in clomiphene-resistant WHO Group II anovulatory subfertile women. Methods: Twenty patients were randomized to receive either Metrodin intramuscularly or Metrodin HP subcutaneously and underwent 45 treatment cycles. A maximum of 3 cycles were offered unless conception or severe adverse reaction occurred. The presence of redness, swelling, bruising and pain of the injection sites was noted and compared. Results: Seven patients became pregnant (3 in the Metrodin group and 4 in the Metrodin HP group) and the pregnancy rates per patient and per cycle were 7/20 (35%) and 7/45 (15.6%), respectively. No local reactions were found in the majority of cycles. There was no significant difference in pregnancy rates and the number of cycles complicated by bruise, pain, itching, redness or swelling between these 2 groups. Conclusions: This clinical study shows that in WHO Group II anovulatory patients Metrodin HP administered subcutaneously by self-injection is as safe and effective as Metrodin administered intramuscularly in inducing ovulation.
Persistent Identifierhttp://hdl.handle.net/10722/87259
ISSN
2015 Impact Factor: 1.091
2015 SCImago Journal Rankings: 0.521
References

 

DC FieldValueLanguage
dc.contributor.authorNg, HYEen_HK
dc.contributor.authorTang, OSFen_HK
dc.contributor.authorSo, WKWen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:27:23Z-
dc.date.available2010-09-06T09:27:23Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Obstetrics And Gynaecology Research, 1998, v. 24 n. 5, p. 355-361en_HK
dc.identifier.issn1341-8076en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87259-
dc.description.abstractObjective: To assess the efficacy and safety of 2 gonadotropin preparations in inducing ovulation in clomiphene-resistant WHO Group II anovulatory subfertile women. Methods: Twenty patients were randomized to receive either Metrodin intramuscularly or Metrodin HP subcutaneously and underwent 45 treatment cycles. A maximum of 3 cycles were offered unless conception or severe adverse reaction occurred. The presence of redness, swelling, bruising and pain of the injection sites was noted and compared. Results: Seven patients became pregnant (3 in the Metrodin group and 4 in the Metrodin HP group) and the pregnancy rates per patient and per cycle were 7/20 (35%) and 7/45 (15.6%), respectively. No local reactions were found in the majority of cycles. There was no significant difference in pregnancy rates and the number of cycles complicated by bruise, pain, itching, redness or swelling between these 2 groups. Conclusions: This clinical study shows that in WHO Group II anovulatory patients Metrodin HP administered subcutaneously by self-injection is as safe and effective as Metrodin administered intramuscularly in inducing ovulation.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia.en_HK
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_HK
dc.subjectGonadotropinsen_HK
dc.subjectOvulation inductionen_HK
dc.subjectWHO Group II anovulationen_HK
dc.titleA prospective, open, randomized clinical study to assess the efficacy and safety of two gonadotropin preparations administered in WHO Group II anovulatory subfertile womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1341-8076&volume=24&issue=5&spage=355&epage=361&date=1998&atitle=A+prospective,+open,+randomized+clinical+study+to+assess+the+efficacy+and+safety+of+two+gonadotropin+preparations+administered+in+WHO+group+II+anovulatory+subfertile+womenen_HK
dc.identifier.emailNg, HYE:nghye@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, HYE=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9879155-
dc.identifier.scopuseid_2-s2.0-0344404082en_HK
dc.identifier.hkuros39323en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344404082&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue5en_HK
dc.identifier.spage355en_HK
dc.identifier.epage361en_HK
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridNg, HYE=35238184300en_HK
dc.identifier.scopusauthoridTang, OSF=36881248500en_HK
dc.identifier.scopusauthoridSo, WKW=36849240500en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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