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Article: Low incidence of HPV DNA in sera of pretreatment cervical cancer patients

TitleLow incidence of HPV DNA in sera of pretreatment cervical cancer patients
Authors
KeywordsCervical cancer
HPV DNA
PCR
Serum
Issue Date2001
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 2001, v. 82 n. 2, p. 269-272 How to Cite?
AbstractObjective. The aim of this study was to investigate the feasibility of using DNA in the circulation as a diagnostic tool for cervical cancer. Methods. We used PCR followed by Southern hybridization to detect human papillomavirus (HPV) DNA in serum samples taken from patients of cervical cancer before treatment. Results. A total of 60 samples were analyzed. In a set of 40 samples, without knowledge of the HPV DNA status in the corresponding cervical carcinomas, we could detect 8 (20%) positive samples, of which 7 (17.5%) were HPV 16 and 1 (2.5%) was HPV 18. In another set of 20 samples, known to be HPV 16 infected in the corresponding cervical carcinomas, we detected only 4 (20%) HPV-16-positive samples. The occurrence of HPV DNA in sera of cervical cancer patients seems sporadic. Conclusion. The low incidence indicates that serum HPV DNA has limited application in the diagnosis of cervical cancer. © 2001 Academic Press.
Persistent Identifierhttp://hdl.handle.net/10722/87231
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorTsang, Pen_HK
dc.contributor.authorYip, Aen_HK
dc.contributor.authorNg, TYen_HK
dc.contributor.authorWong, LCen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:27:01Z-
dc.date.available2010-09-06T09:27:01Z-
dc.date.issued2001en_HK
dc.identifier.citationGynecologic Oncology, 2001, v. 82 n. 2, p. 269-272en_HK
dc.identifier.issn0090-8258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87231-
dc.description.abstractObjective. The aim of this study was to investigate the feasibility of using DNA in the circulation as a diagnostic tool for cervical cancer. Methods. We used PCR followed by Southern hybridization to detect human papillomavirus (HPV) DNA in serum samples taken from patients of cervical cancer before treatment. Results. A total of 60 samples were analyzed. In a set of 40 samples, without knowledge of the HPV DNA status in the corresponding cervical carcinomas, we could detect 8 (20%) positive samples, of which 7 (17.5%) were HPV 16 and 1 (2.5%) was HPV 18. In another set of 20 samples, known to be HPV 16 infected in the corresponding cervical carcinomas, we detected only 4 (20%) HPV-16-positive samples. The occurrence of HPV DNA in sera of cervical cancer patients seems sporadic. Conclusion. The low incidence indicates that serum HPV DNA has limited application in the diagnosis of cervical cancer. © 2001 Academic Press.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_HK
dc.relation.ispartofGynecologic Oncologyen_HK
dc.subjectCervical canceren_HK
dc.subjectHPV DNAen_HK
dc.subjectPCRen_HK
dc.subjectSerumen_HK
dc.titleLow incidence of HPV DNA in sera of pretreatment cervical cancer patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0090-8258&volume=82&spage=269&epage=272&date=2001&atitle=Low+incidence+of+HPV+DNA+in+sera+of+pretreatment+cervical+cancer+patientsen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/gyno.2001.6289en_HK
dc.identifier.pmid11531278-
dc.identifier.scopuseid_2-s2.0-0034898370en_HK
dc.identifier.hkuros65286en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034898370&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue2en_HK
dc.identifier.spage269en_HK
dc.identifier.epage272en_HK
dc.identifier.isiWOS:000170508600009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridTsang, P=7102404070en_HK
dc.identifier.scopusauthoridYip, A=19838748300en_HK
dc.identifier.scopusauthoridNg, TY=7402229853en_HK
dc.identifier.scopusauthoridWong, LC=55436382200en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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