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Article: Relapsed gestational trophoblastic neoplasia: A 20-year experience

TitleRelapsed gestational trophoblastic neoplasia: A 20-year experience
Authors
KeywordsGestational trophoblastic neoplasms
Hong Kong
Relapse
Issue Date2006
PublisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.com
Citation
Journal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2006, v. 51 n. 10, p. 829-834 How to Cite?
AbstractOBJECTIVE: To review relapsed gestational trophoblastic neoplasia (GTN). STUDY DESIGN: Patients who had relapsed GTN between 1978 and 2001 at Queen Mary Hospital were included in the study. Records were reviewed and data analyzed regarding treatment, follow-up and survival. RESULTS: Eighteen patients with relapsed GTN were identified. Patients' ages ranged from 27 to 56 years, with a median of 34. Eight were classified as low risk, 1 as medium risk and 9 as high risk at the time of diagnosis. Seven, 3 and 8 patients were treated with single-, dual- and multiple-agent chemotherapy, respectively. The median interval between remission and relapse was 6.5 months (range, 1-132). The time interval to relapse did not correlate with patient mortality (Mann-Whitney U test, p = 0.873). Four patients died of the disease, and all of them were classified and treated as low risk at the time of diagnosis. Three were lost to follow-up at some point. The remaining patient had relapsed choriocarcinoma and developed progressive disease despite intensive multiple-modality treatment. The overall survival rate for relapsed GTN was 77.8%. CONCLUSION: Patients with relapsed GTN are salvageable. Failure of treatment seems attributable to patients who defaulted treatment or follow-up and presented late until massive disease. © Journal of Reproductive Medicine®, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/87177
ISSN
2015 Impact Factor: 0.84
2015 SCImago Journal Rankings: 0.388
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorLam, KWen_HK
dc.contributor.authorChan, KKLen_HK
dc.date.accessioned2010-09-06T09:26:19Z-
dc.date.available2010-09-06T09:26:19Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2006, v. 51 n. 10, p. 829-834en_HK
dc.identifier.issn0024-7758en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87177-
dc.description.abstractOBJECTIVE: To review relapsed gestational trophoblastic neoplasia (GTN). STUDY DESIGN: Patients who had relapsed GTN between 1978 and 2001 at Queen Mary Hospital were included in the study. Records were reviewed and data analyzed regarding treatment, follow-up and survival. RESULTS: Eighteen patients with relapsed GTN were identified. Patients' ages ranged from 27 to 56 years, with a median of 34. Eight were classified as low risk, 1 as medium risk and 9 as high risk at the time of diagnosis. Seven, 3 and 8 patients were treated with single-, dual- and multiple-agent chemotherapy, respectively. The median interval between remission and relapse was 6.5 months (range, 1-132). The time interval to relapse did not correlate with patient mortality (Mann-Whitney U test, p = 0.873). Four patients died of the disease, and all of them were classified and treated as low risk at the time of diagnosis. Three were lost to follow-up at some point. The remaining patient had relapsed choriocarcinoma and developed progressive disease despite intensive multiple-modality treatment. The overall survival rate for relapsed GTN was 77.8%. CONCLUSION: Patients with relapsed GTN are salvageable. Failure of treatment seems attributable to patients who defaulted treatment or follow-up and presented late until massive disease. © Journal of Reproductive Medicine®, Inc.en_HK
dc.languageengen_HK
dc.publisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.comen_HK
dc.relation.ispartofJournal of Reproductive Medicine for the Obstetrician and Gynecologisten_HK
dc.subjectGestational trophoblastic neoplasmsen_HK
dc.subjectHong Kongen_HK
dc.subjectRelapseen_HK
dc.titleRelapsed gestational trophoblastic neoplasia: A 20-year experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1004-3845&volume=51&issue=10&spage=829&epage=834&date=2006&atitle=Relapsed+gestational+trophoblastic+neoplasia:+A+20-year+experienceen_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17086812-
dc.identifier.scopuseid_2-s2.0-33750218017en_HK
dc.identifier.hkuros131848en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750218017&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue10en_HK
dc.identifier.spage829en_HK
dc.identifier.epage834en_HK
dc.identifier.isiWOS:000241341600013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridLam, KW=13407245500en_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK

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