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Article: Testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia

TitleTesticular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia
Authors
KeywordsIntracytoplasmic sperm injection
Non-obstructive azoospermia
Testicular sperm extraction
Issue Date2000
PublisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2000, v. 113 n. 3, p. 246-250 How to Cite?
AbstractObjective To report the experience in sperm extraction from testicular biopsies (TESE) performed from March 1996 to July 1998 in men with non-obstructive azoospermia (NOA). Methods Comparisons of age, volume of both testes, serum FSH and testosterone in men, and histology of testicular samples in the first cycles between cycles with spermatozoa found and those without spermatozoa found were performed. Comparisons of fertilization, cleavage and pregnancy rates between cycles with spermatozoa injected and those with spermatids injected were performed. Results Spermatozoa were found in only 12 out of 26 first TESE cycles (46.2%) and other cycles had spermatids (round cells) only. Age of men, history of mumps orchitis/oligozoospermia, volume of both testes and serum FSH/testosterone levels in men were not significantly different between cycles with and without spermatozoa. The fertilization rate was significantly higher in cycles with spermatozoa injected than those with round cell injections (63.3% vs 23.2%, P < 0.0001, Chi-squared test). The pregnancy rate was 14.3% per cycle when spermatozoa were injected. Conclusions TESE followed by Intracytoplasmic sperm injection (ICSI) is an effective treatment in patients with NOA. Less than half of the patients undergoing TESE had spermatozoa recovered. Age of men, volume of both testes and serum FSH/ testosterone levels in men were not useful in predicting successful recovery. Compared to using ejaculated and epididymal spermatozoa, fertilization and pregnancy rates were achieved when testicular spermatozoa were used for ICSI.
Persistent Identifierhttp://hdl.handle.net/10722/87176
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
References

 

DC FieldValueLanguage
dc.contributor.authorNg, HYEen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorYeung, SBen_HK
dc.contributor.authorSo, WKen_HK
dc.contributor.authorTam, PCen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:26:18Z-
dc.date.available2010-09-06T09:26:18Z-
dc.date.issued2000en_HK
dc.identifier.citationChinese Medical Journal, 2000, v. 113 n. 3, p. 246-250en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87176-
dc.description.abstractObjective To report the experience in sperm extraction from testicular biopsies (TESE) performed from March 1996 to July 1998 in men with non-obstructive azoospermia (NOA). Methods Comparisons of age, volume of both testes, serum FSH and testosterone in men, and histology of testicular samples in the first cycles between cycles with spermatozoa found and those without spermatozoa found were performed. Comparisons of fertilization, cleavage and pregnancy rates between cycles with spermatozoa injected and those with spermatids injected were performed. Results Spermatozoa were found in only 12 out of 26 first TESE cycles (46.2%) and other cycles had spermatids (round cells) only. Age of men, history of mumps orchitis/oligozoospermia, volume of both testes and serum FSH/testosterone levels in men were not significantly different between cycles with and without spermatozoa. The fertilization rate was significantly higher in cycles with spermatozoa injected than those with round cell injections (63.3% vs 23.2%, P < 0.0001, Chi-squared test). The pregnancy rate was 14.3% per cycle when spermatozoa were injected. Conclusions TESE followed by Intracytoplasmic sperm injection (ICSI) is an effective treatment in patients with NOA. Less than half of the patients undergoing TESE had spermatozoa recovered. Age of men, volume of both testes and serum FSH/ testosterone levels in men were not useful in predicting successful recovery. Compared to using ejaculated and epididymal spermatozoa, fertilization and pregnancy rates were achieved when testicular spermatozoa were used for ICSI.en_HK
dc.languageengen_HK
dc.publisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subjectIntracytoplasmic sperm injectionen_HK
dc.subjectNon-obstructive azoospermiaen_HK
dc.subjectTesticular sperm extractionen_HK
dc.titleTesticular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0366-6999&volume=113&issue=3&spage=246&epage=250&date=2000&atitle=Testicular+sperm+extraction+and+intracytoplasmic+sperm+injection+in+non-obstructive+azoospermiaen_HK
dc.identifier.emailNg, HYE:nghye@hkucc.hku.hken_HK
dc.identifier.emailYeung, SB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, HYE=rp00426en_HK
dc.identifier.authorityYeung, SB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11775256-
dc.identifier.scopuseid_2-s2.0-0034160804en_HK
dc.identifier.hkuros48857en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034160804&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume113en_HK
dc.identifier.issue3en_HK
dc.identifier.spage246en_HK
dc.identifier.epage250en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridNg, HYE=35238184300en_HK
dc.identifier.scopusauthoridLau, YL=7103086093en_HK
dc.identifier.scopusauthoridYeung, SB=7102370745en_HK
dc.identifier.scopusauthoridSo, WK=36849240300en_HK
dc.identifier.scopusauthoridTam, PC=7202539419en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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