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Article: 20-Year experience of managing profuse bleeding in gestational trophoblastic disease

Title20-Year experience of managing profuse bleeding in gestational trophoblastic disease
Authors
Issue Date2007
PublisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.com
Citation
Journal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2007, v. 52 n. 5, p. 397-401 How to Cite?
AbstractOBJECTIVE: To review the outcomes of different methods in the treatment of severe bleeding or acute abdomen in gestational trophoblastic disease (GTD). STUDY DESIGN: In a tertiary referral center, the records of patients diagnosed with GTD and presenting with heavy vaginal bleeding or acute abdomen between January 1986 and December 2005 were retrieved. RESULTS: Seventeen patients presenting with heavy bleeding or acute abdomen and requiring emergency management were identified. Ten patients had heavy vaginal bleeding, and 7 had shock or signs of hemoperitoneum. Eleven patients had total abdominal hysterectomy with or without bilateral salpingo-oophorectomy (TAH ± BSO), 2 had arterial ligation, 3 had embolization, and 1 had suturing of a vaginal defect due to a metastatic nodule. The median ages of the patients having TAH ± BSO and other conservative treatments were 37 (21-52) and 32.5 (26-48), respectively. Fifteen patients received chemotherapy after surgical treatment. All patients survived except 1, who died of concurrent disease. CONCLUSION: Profuse bleeding in GTD is rare. Hysterectomy, arterial ligation and angiographic embolization can effectively treat this condition. With more experience, angiographic embolization should be the treatment of choice, especially for those who are hemodynamically stable and wish to retain their fertility potential. © Journal of Reproductive Medicine®, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/87169
ISSN
2015 Impact Factor: 0.84
2015 SCImago Journal Rankings: 0.388
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKa, YTen_HK
dc.contributor.authorChan, KKLen_HK
dc.contributor.authorKar, FTen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:26:13Z-
dc.date.available2010-09-06T09:26:13Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2007, v. 52 n. 5, p. 397-401en_HK
dc.identifier.issn0024-7758en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87169-
dc.description.abstractOBJECTIVE: To review the outcomes of different methods in the treatment of severe bleeding or acute abdomen in gestational trophoblastic disease (GTD). STUDY DESIGN: In a tertiary referral center, the records of patients diagnosed with GTD and presenting with heavy vaginal bleeding or acute abdomen between January 1986 and December 2005 were retrieved. RESULTS: Seventeen patients presenting with heavy bleeding or acute abdomen and requiring emergency management were identified. Ten patients had heavy vaginal bleeding, and 7 had shock or signs of hemoperitoneum. Eleven patients had total abdominal hysterectomy with or without bilateral salpingo-oophorectomy (TAH ± BSO), 2 had arterial ligation, 3 had embolization, and 1 had suturing of a vaginal defect due to a metastatic nodule. The median ages of the patients having TAH ± BSO and other conservative treatments were 37 (21-52) and 32.5 (26-48), respectively. Fifteen patients received chemotherapy after surgical treatment. All patients survived except 1, who died of concurrent disease. CONCLUSION: Profuse bleeding in GTD is rare. Hysterectomy, arterial ligation and angiographic embolization can effectively treat this condition. With more experience, angiographic embolization should be the treatment of choice, especially for those who are hemodynamically stable and wish to retain their fertility potential. © Journal of Reproductive Medicine®, Inc.en_HK
dc.languageengen_HK
dc.publisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.comen_HK
dc.relation.ispartofJournal of Reproductive Medicine for the Obstetrician and Gynecologisten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAngiographyen_HK
dc.subject.meshArteries - surgeryen_HK
dc.subject.meshEmbolization, Therapeuticen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGestational Trophoblastic Disease - complications - epidemiologyen_HK
dc.subject.meshHemostatic Techniques - utilizationen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHysterectomyen_HK
dc.subject.meshLigationen_HK
dc.subject.meshMedical Recordsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshRadiography, Interventionalen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshUterine Hemorrhage - etiology - radiography - therapyen_HK
dc.subject.meshUterine Neoplasms - complications - epidemiologyen_HK
dc.title20-Year experience of managing profuse bleeding in gestational trophoblastic diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1004-3845&volume=52&issue=5&spage=397&epage=401&date=2007&atitle=20-year+experience+of+managing+profuse+bleeding+in+gestational+trophoblastic+diseaseen_HK
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17583238-
dc.identifier.scopuseid_2-s2.0-34249037682en_HK
dc.identifier.hkuros132020en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249037682&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue5en_HK
dc.identifier.spage397en_HK
dc.identifier.epage401en_HK
dc.identifier.isiWOS:000246676300009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKa, YT=16316188800en_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK
dc.identifier.scopusauthoridKar, FT=16316390500en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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