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Article: Tumour markers and their prognostic value in adenocarcinoma of the cervix

TitleTumour markers and their prognostic value in adenocarcinoma of the cervix
Authors
KeywordsAdenocarcinoma of cervix
CA 125
Carcinoembryonic antigen
Squamous cell carcinoma antigen
Tissue polypeptide antigen
Issue Date1998
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBI
Citation
Tumor Biology, 1998, v. 19 n. 6, p. 439-444 How to Cite?
AbstractNinety-one patients with adenocarcinoma of the cervix had 4 tumour markers (TMs) assayed before treatment. Serum squamous cell carcinoma antigen (SCC) (n = 91) was raised in 25%; tissue polypeptide antigen (TPA) (n = 78) was raised in 35%; carcinoembryonic antigen (CEA) (n = 34) was raised in 26% and CA 125 (n = 64) was raised in 27% of these patients. In 47 of these 91 patients (52%), 1 or more of the markers were raised. The percentage of patients with raised TM increased with advancing stage. Univariate survival analysis showed that age, stage, raised TPA, raised CA 125, and raised TMs (any one or more) were of prognostic significance. When multivariate analysis was done and each TM was individually analysed, only age, stage and raised CA 125 were of prognostic significance. Rising SCC or TPA or CA 125 levels in serial estimations correlated well with the occurrence of recurrence. Thus, pretreatment estimation of SCC, TPA and CA 125 can be used to identify the patients who can subsequently be monitored by serial TM estimation.
Persistent Identifierhttp://hdl.handle.net/10722/87115
ISSN
2015 Impact Factor: 2.926
2015 SCImago Journal Rankings: 0.989
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorLander, IJen_HK
dc.contributor.authorCheng, DKLen_HK
dc.contributor.authorWong, LCen_HK
dc.contributor.authorMa, HKen_HK
dc.date.accessioned2010-09-06T09:25:31Z-
dc.date.available2010-09-06T09:25:31Z-
dc.date.issued1998en_HK
dc.identifier.citationTumor Biology, 1998, v. 19 n. 6, p. 439-444en_HK
dc.identifier.issn1010-4283en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87115-
dc.description.abstractNinety-one patients with adenocarcinoma of the cervix had 4 tumour markers (TMs) assayed before treatment. Serum squamous cell carcinoma antigen (SCC) (n = 91) was raised in 25%; tissue polypeptide antigen (TPA) (n = 78) was raised in 35%; carcinoembryonic antigen (CEA) (n = 34) was raised in 26% and CA 125 (n = 64) was raised in 27% of these patients. In 47 of these 91 patients (52%), 1 or more of the markers were raised. The percentage of patients with raised TM increased with advancing stage. Univariate survival analysis showed that age, stage, raised TPA, raised CA 125, and raised TMs (any one or more) were of prognostic significance. When multivariate analysis was done and each TM was individually analysed, only age, stage and raised CA 125 were of prognostic significance. Rising SCC or TPA or CA 125 levels in serial estimations correlated well with the occurrence of recurrence. Thus, pretreatment estimation of SCC, TPA and CA 125 can be used to identify the patients who can subsequently be monitored by serial TM estimation.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBIen_HK
dc.relation.ispartofTumor Biologyen_HK
dc.subjectAdenocarcinoma of cervixen_HK
dc.subjectCA 125en_HK
dc.subjectCarcinoembryonic antigenen_HK
dc.subjectSquamous cell carcinoma antigenen_HK
dc.subjectTissue polypeptide antigenen_HK
dc.subject.meshAdenocarcinoma - blood - pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAntigens, Neoplasm - blooden_HK
dc.subject.meshCA-125 Antigen - blooden_HK
dc.subject.meshCarcinoembryonic Antigen - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSerpinsen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTissue Polypeptide Antigen - blooden_HK
dc.subject.meshTumor Markers, Biological - blooden_HK
dc.subject.meshUterine Cervical Neoplasms - blood - pathologyen_HK
dc.titleTumour markers and their prognostic value in adenocarcinoma of the cervixen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1010-4283&volume=19&spage=439&epage=444&date=1998&atitle=Tumour+Markers+and+Their+Prognostic+Value+in+Adenocarcinoma+of+the+Cervixen_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9817971-
dc.identifier.scopuseid_2-s2.0-0031792879en_HK
dc.identifier.hkuros38903en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031792879&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue6en_HK
dc.identifier.spage439en_HK
dc.identifier.epage444en_HK
dc.identifier.isiWOS:000077274600002-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridLander, IJ=6504734326en_HK
dc.identifier.scopusauthoridCheng, DKL=7402806161en_HK
dc.identifier.scopusauthoridWong, LC=7402092003en_HK
dc.identifier.scopusauthoridMa, HK=7403095603en_HK

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