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Article: Randomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage

TitleRandomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stage
Authors
KeywordsFrozen-thawed embryo transfer
laser assisted hatching
zona breaching and zona thinning
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility And Sterility, 2008, v. 89 n. 5, p. 1147-1153 How to Cite?
AbstractObjective: To compare the implantation and ongoing pregnancy rates of frozen-thawed embryo transfer (FET) using laser thinning with those of laser breaching of the zona pellucida (ZP). Design: Double-blind randomized study. Setting: A tertiary assisted reproduction unit. Patient(s): Infertile patients undergoing FET cycles. Intervention(s): In the thinning group, more than a quarter of the ZP's outer half-diameter was removed by using a 1,480-nm noncontact laser, whereas a hole about 30 μm in size was created in the ZP in the breaching group. Main Outcome Measure(s): Implantation and ongoing pregnancy rates. Result(s): On the day of the FET, 180 patients were randomly divided into the thinning and breaching groups according to a computer-generated randomization list that was placed in sealed envelopes. The two groups were comparable in terms of demographic characteristics, ovarian response of the stimulated cycle, and quality of fresh and frozen-thawed embryos. The implantation and ongoing pregnancy rates of the thinning group were significantly higher than the corresponding rates of the breaching group but were similar to those of patients without ZP thinning or breaching. Conclusion(s): Laser ZP thinning is associated with significantly higher implantation and ongoing pregnancy rates in FET cycles compared with the case of laser ZP breaching. © 2008 American Society for Reproductive Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/87053
ISSN
2015 Impact Factor: 4.426
2015 SCImago Journal Rankings: 2.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorLau, EYLen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorCheung, TMen_HK
dc.contributor.authorTang, OSen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:24:42Z-
dc.date.available2010-09-06T09:24:42Z-
dc.date.issued2008en_HK
dc.identifier.citationFertility And Sterility, 2008, v. 89 n. 5, p. 1147-1153en_HK
dc.identifier.issn0015-0282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87053-
dc.description.abstractObjective: To compare the implantation and ongoing pregnancy rates of frozen-thawed embryo transfer (FET) using laser thinning with those of laser breaching of the zona pellucida (ZP). Design: Double-blind randomized study. Setting: A tertiary assisted reproduction unit. Patient(s): Infertile patients undergoing FET cycles. Intervention(s): In the thinning group, more than a quarter of the ZP's outer half-diameter was removed by using a 1,480-nm noncontact laser, whereas a hole about 30 μm in size was created in the ZP in the breaching group. Main Outcome Measure(s): Implantation and ongoing pregnancy rates. Result(s): On the day of the FET, 180 patients were randomly divided into the thinning and breaching groups according to a computer-generated randomization list that was placed in sealed envelopes. The two groups were comparable in terms of demographic characteristics, ovarian response of the stimulated cycle, and quality of fresh and frozen-thawed embryos. The implantation and ongoing pregnancy rates of the thinning group were significantly higher than the corresponding rates of the breaching group but were similar to those of patients without ZP thinning or breaching. Conclusion(s): Laser ZP thinning is associated with significantly higher implantation and ongoing pregnancy rates in FET cycles compared with the case of laser ZP breaching. © 2008 American Society for Reproductive Medicine.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnsterten_HK
dc.relation.ispartofFertility and Sterilityen_HK
dc.rightsFertility and Sterility. Copyright © Elsevier Inc.en_HK
dc.subjectFrozen-thawed embryo transferen_HK
dc.subjectlaser assisted hatchingen_HK
dc.subjectzona breaching and zona thinningen_HK
dc.titleRandomized double-blind comparison of laser zona pellucida thinning and breaching in frozen-thawed embryo transfer at the cleavage stageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0015-0282&volume=89&issue=5&spage=1147&epage=1153&date=2008&atitle=Randomized+double-blind+comparison+of+laser+zona+pellucida+thinning+and+breaching+in+frozen-thawed+embryo+transfer+at+the+cleavage+stageen_HK
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_HK
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.fertnstert.2007.05.016en_HK
dc.identifier.pmid17662284-
dc.identifier.scopuseid_2-s2.0-43449128847en_HK
dc.identifier.hkuros146342en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43449128847&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1147en_HK
dc.identifier.epage1153en_HK
dc.identifier.isiWOS:000256075700017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridLau, EYL=7103086093en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridCheung, TM=7103334551en_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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